SCFs in the new millennium (Q38102567)

28 August 2017

SCFs in the new millennium (English)

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28 August 2017

E K Lee

1

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28 August 2017

J A Diehl

series ordinal

2

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28 August 2017

language of work or name

English

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publication date

29 April 2013

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28 August 2017

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28 August 2017

33

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28 August 2017

16

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28 August 2017

2011-2018

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https://scigraph.springernature.com/pub.10.1038/onc.2013.144

28 August 2017

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cites work

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Function and regulation of cullin-RING ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The COP9 Signalosome Promotes Degradation of Cyclin E during Early Drosophila Oogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCFFWD-1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Structural basis for a reciprocal regulation between SCF and CSN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Fbw7 isoform interaction contributes to cyclin E proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ɛ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Context of multiubiquitin chain attachment influences the rate of Sic1 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Detection of sequential polyubiquitylation on a millisecond timescale

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Evaluation of a diffusion-driven mechanism for substrate ubiquitination by the SCF-Cdc34 ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

RING domain E3 ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Identification of SCF ubiquitin ligase substrates by global protein stability profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Global identification of modular cullin-RING ligase substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

E3 ubiquitin ligase that recognizes sugar chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Inactivation of hCDC4 can cause chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The ubiquitin-specific protease USP28 is required for MYC stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The genomic landscapes of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Cks1 regulates cdk1 expression: a novel role during mitotic entry in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

alphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Role of Pin2/TRF1 in telomere maintenance and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.144

31 March 2020

Identifiers

DOI

10.1038/ONC.2013.144

1 reference

Dimensions Publication ID

28 August 2017

0 references

1 reference