Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool (Q38126982)

29 August 2017

Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool (English)

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29 August 2017

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Vittoria Infantino

3

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Vito Iacobazzi

object named as

Vito Iacobazzi

series ordinal

1

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author name string

Alessandra Castegna

series ordinal

2

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PubMed ID

23920043

29 August 2017

Generoso Andria

series ordinal

4

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29 August 2017

19 July 2013

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Molecular Genetics and Metabolism

29 August 2017

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29 August 2017

110

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29 August 2017

25-34

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29 August 2017

1-2

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Conservation and divergence in eukaryotic DNA methylation.

29 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

5-methylcytidylic acid: absence from mitochondrial DNA of frogs and HeLa cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Methylated bases in DNA from Paramecium aurelia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells. In vivo and in vitro methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Methylation pattern of mouse mitochondrial DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Mitochondrial DNA from various organisms does not contain internally methylated cytosine in -CCGG- sequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Organization of multiple nucleoids and DNA molecules in mitochondria of a human cell

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Epigenetic regulation of motor neuron cell death through DNA methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Progress in mitochondrial epigenetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

DNA methylation changes in prostate cancer: current developments and future clinical implementation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

DNA methylation as a universal biomarker

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

DNA methylation based biomarkers in non-invasive cancer screening

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Importance of methyl donors during reproduction

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Mitochondrial control of epigenetics

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Mitochondrial one-carbon metabolism is adapted to the specific needs of yeast, plants and mammals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Folic acid: nutritional biochemistry, molecular biology, and role in disease processes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Folate, homocysteine, endothelial function and cardiovascular disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Role of Folate in Colon Cancer Development and Progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Serum homocysteine and dementia: meta-analysis of eight cohort studies including 8669 participants.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Relation between plasma homocysteine and Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Sequence and organization of the human mitochondrial genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

DNA replication and transcription in mammalian mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

In vivo methylation of mtDNA reveals the dynamics of protein-mtDNA interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Mitochondrial mutagenesis in human cells and tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Mammalian mitochondrial genetics: heredity, heteroplasmy and disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

The power and the promise of DNA methylation markers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

DNA methylation and cancer diagnosis: new methods and applications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Circulating cell-free DNA: a novel biomarker for response to therapy in ovarian carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

DNA methylation in white blood cells: association with risk factors in epidemiologic studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Fetal-specific DNA methylation ratio permits noninvasive prenatal diagnosis of trisomy 21.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Mitochondrial dysfunction and Down's syndrome.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

A mitochondrial etiology of Alzheimer and Parkinson disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Effect of valproic acid on mitochondrial epigenetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Mitochondrial formation of reactive oxygen species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Induction of epigenetic alterations by dietary and other environmental factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Brain aging, Alzheimer's disease, and mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Effect of aging on 5-hydroxymethylcytosine in brain mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Transcription and replication of mitochondrial DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Coupling the mitochondrial transcription machinery to human disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Comparison of human and hamster mitochondrial transfer RNA. Physical properties and methylation status

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Methylated nucleotide content of mitochondrial ribosomal RNA from hamster cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Implications of a functional large ribosomal RNA with only three modified nucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Genome-wide approaches to studying chromatin modifications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

DNA methylation in cancer: too much, but also too little

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

High-resolution profiling of histone methylations in the human genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

A chromatin landmark and transcription initiation at most promoters in human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Mitochondrial nucleoids undergo remodeling in response to metabolic cues.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Purification of CpG islands using a methylated DNA binding column

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Evidence for an instructive mechanism of de novo methylation in cancer cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Discovery of bisulfite-mediated cytosine conversion to uracil, the key reaction for DNA methylation analysis--a personal account

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Genome-wide high throughput analysis of DNA methylation in eukaryotes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Genome-wide, high-resolution DNA methylation profiling using bisulfite-mediated cytosine conversion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

DNA methylation and gene expression differences in children conceived in vitro or in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

A microarray-based DNA methylation study of glioblastoma multiforme

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Whole genome genotyping technologies on the BeadArray platform

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Genome-wide DNA methylation profiling using Infinium® assay

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Human DNA methylomes at base resolution show widespread epigenomic differences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Heterogeneity of DNA methylation status analyzed by bisulfite-PCR-SSCP and correlation with clinico-pathological characteristics in colorectal cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Regionally specific and genome-wide analyses conclusively demonstrate the absence of CpG methylation in human mitochondrial DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Restriction landmark genomic scanning method and its various applications

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

7 January 2021

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

inferred from DOI database lookup

7 January 2021

based on heuristic

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Identification of DNA methylation differences during tumorigenesis by methylation-sensitive arbitrarily primed polymerase chain reaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Methylome profiling of cancer cells by amplification of inter-methylated sites (AIMS).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

High-throughput methylation profiling by MCA coupled to CpG island microarray

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Identification of novel high-frequency DNA methylation changes in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Comprehensive high-throughput arrays for relative methylation (CHARM).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

MMASS: an optimized array-based method for assessing CpG island methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Locking in on the human methylome.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

The potential and challenges of nanopore sequencing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Continuous base identification for single-molecule nanopore DNA sequencing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Insufficient DNA methylation affects healthy aging and promotes age-related health problems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2013.07.012

10.1016/J.YMGME.2013.07.012

7 January 2021

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

23920043