Leptin and adiponectin: emerging therapeutic targets in breast cancer (Q38153628)

29 August 2017

Leptin and adiponectin: emerging therapeutic targets in breast cancer (English)

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29 August 2017

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Eva Surmacz

1

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29 August 2017

18 October 2013

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Journal of Mammary Gland Biology and Neoplasia

29 August 2017

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29 August 2017

18

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29 August 2017

321-332

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29 August 2017

3-4

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https://scigraph.springernature.com/pub.10.1007/s10911-013-9302-8

29 August 2017

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Leptin induces increased α2(I) collagen gene expression in cultured rat hepatic stellate cells

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21 January 2018

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Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion

21 January 2018

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Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3)

21 January 2018

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Adiponectin attenuates endothelial dysfunction induced by oxidised low-density lipoproteins

21 January 2018

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Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies

21 January 2018

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Adiponectin and breast cancer risk

21 January 2018

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21 January 2018

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21 January 2018

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Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition

21 January 2018

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Effects of adiponectin on breast cancer cell growth and signaling

21 January 2018

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Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell

21 January 2018

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New insights into anticarcinogenic properties of adiponectin: a potential therapeutic approach in breast cancer?

21 January 2018

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Design and development of a peptide-based adiponectin receptor agonist for cancer treatment

21 January 2018

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Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.

21 January 2018

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LKB1 is required for adiponectin-mediated modulation of AMPK-S6K axis and inhibition of migration and invasion of breast cancer cells

21 January 2018

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Metastasis suppression by adiponectin: LKB1 rises up to the challenge

21 January 2018

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Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells

21 January 2018

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Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities

21 January 2018

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Breast cancer and obesity: in vitro interferences between adipokines and proangiogenic features and/or antitumor therapies?

21 January 2018

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Impact of AdipoR1 expression on breast cancer development

21 January 2018

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Influence of insulin resistance on adiponectin receptor expression in breast cancer.

21 January 2018

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Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells

21 January 2018

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Growth-inhibitory effect of adiponectin via adiponectin receptor 1 on human breast cancer cells through inhibition of S-phase entry without inducing apoptosis

21 January 2018

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Prediagnostic leptin, adiponectin, C-reactive protein, and the risk of postmenopausal breast cancer

21 January 2018

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Integral role of PTP1B in adiponectin-mediated inhibition of oncogenic actions of leptin in breast carcinogenesis

21 January 2018

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Adiponectin, an anti-carcinogenic hormone? A systematic review on breast, colorectal, liver and prostate cancer.

21 January 2018

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Metformin: taking away the candy for cancer?

21 January 2018

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Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

21 January 2018

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A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells.

21 January 2018

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Leptin serves as an upstream activator of an obligatory signaling cascade in the embryo-implantation process

21 January 2018

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Vascular endothelial growth factor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenic actions of leptin on human endothelial cells

21 January 2018

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Development of a pharmacologically improved peptide agonist of the leptin receptor

21 January 2018

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Peptide-based leptin receptor antagonists for cancer treatment and appetite regulation

21 January 2018

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Leptin upregulates tissue factor expression in human breast cancer MCF-7 cells

21 January 2018

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Cellular and molecular crosstalk between leptin receptor and estrogen receptor-{alpha} in breast cancer: molecular basis for a novel therapeutic setting

21 January 2018

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Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation

21 January 2018

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Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy

21 January 2018

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Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei.

21 January 2018

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leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

21 January 2018

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Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin

21 January 2018

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Leptin augments proliferation of breast cancer cells via transactivation of HER2.

21 January 2018

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Upregulation of survivin by leptin/STAT3 signaling in MCF-7 cells

21 January 2018

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Leptin Enhances, via AP-1, Expression of Aromatase in the MCF-7 Cell Line

21 January 2018

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Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype

21 January 2018

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Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells

21 January 2018

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Metformin--the gold standard in type 2 diabetes: what does the evidence tell us?

21 January 2018

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Metformin action on AMP-activated protein kinase: a translational research approach to understanding a potential new therapeutic target.

21 January 2018

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Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt.

21 January 2018

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An energetic tale of AMPK-independent effects of metformin.

21 January 2018

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The AMP-activated protein kinase pathway--new players upstream and downstream.

21 January 2018

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Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers

21 January 2018

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A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells

21 January 2018

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The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

21 January 2018

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Metformin for aging and cancer prevention

21 January 2018

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Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

21 January 2018

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Metformin: a therapeutic opportunity in breast cancer

21 January 2018

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Metformin and cancer: new applications for an old drug

21 January 2018

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Metformin and other biguanides in oncology: advancing the research agenda

21 January 2018

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Targeting AMPK: a new therapeutic opportunity in breast cancer

21 January 2018

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Demographic and clinico-pathological characteristics in patients with invasive breast cancer receiving metformin.

21 January 2018

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Metformin as an energy restriction mimetic agent for breast cancer prevention

21 January 2018

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Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer

21 January 2018

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Unraveling the mechanism of action of thiazolidinediones

21 January 2018

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In vivo and in vitro evidence that PPARγ ligands are antagonists of leptin signaling in breast cancer

21 January 2018

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Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapy.

21 January 2018

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Subcellular localization and internalization of the four human leptin receptor isoforms

21 January 2018

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12 December 2020

Adiponectin mediates an antiproliferative response in human MDA-MB 231 breast cancer cells

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Adiponectin activates c-Jun NH2-terminal kinase and inhibits signal transducer and activator of transcription 3

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The emerging role of adipokines in osteoarthritis: a narrative review

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Obesity hormone leptin: a new target in breast cancer?

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Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence

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Adiponectin: a risk biomarker and attractive target for chemoprevention

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Effects of activation of AMPK on human breast cancer cell lines with different genetic backgrounds.

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Serum leptin concentration in moderate and severe obesity: relationship with clinical, anthropometric and metabolic factors

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12 December 2020

Central nervous system control of food intake

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12 December 2020

Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1α

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12 December 2020

Globular adiponectin protects human umbilical vein endothelial cells against apoptosis through adiponectin receptor 1/adenosine monophosphate-activated protein kinase pathway.

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12 December 2020

Leptin regulates cyclin D1 in luminal epithelial cells of mouse MMTV-Wnt-1 mammary tumors

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12 December 2020

The anti-diabetic drug metformin suppresses the metastasis-associated protein CD24 in MDA-MB-468 triple-negative breast cancer cells.

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12 December 2020

Role of Notch and its oncogenic signaling crosstalk in breast cancer

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12 December 2020

Targeting the leptin receptor: a potential new mode of treatment for breast cancer

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12 December 2020

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12 December 2020

Metformin inhibits leptin-induced growth and migration of glioblastoma cells

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12 December 2020

The balance between leptin and adiponectin in the control of carcinogenesis - focus on mammary tumorigenesis

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12 December 2020

Adipocytokines and breast cancer risk.

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Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans

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Globular adiponectin activates nuclear factor-kappaB in vascular endothelial cells, which in turn induces expression of proinflammatory and adhesion molecule genes

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Effects of PPARγ agonists on the expression of leptin and vascular endothelial growth factor in breast cancer cells

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10.1007/S10911-013-9302-8

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

24136336