5-hydroxymethylcytosine profiling as an indicator of cellular state (Q38166838)

30 August 2017

5-hydroxymethylcytosine profiling as an indicator of cellular state (English)

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30 August 2017

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24283880%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Richard Meehan

series ordinal

4

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9 June 2020

author name string

Alexander Laird

series ordinal

1

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9 June 2020

John P Thomson

series ordinal

2

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9 June 2020

publication date

1 December 2013

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30 August 2017

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9 June 2020

volume

5

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9 June 2020

issue

6

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9 June 2020

page(s)

655-669

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An operational definition of epigenetics

9 June 2020

cites work

1 reference

Perceptions of epigenetics

21 January 2018

1 reference

Histone H4K20me3 and HP1α are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells.

21 January 2018

1 reference

Stability and flexibility of epigenetic gene regulation in mammalian development

21 January 2018

1 reference

Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway

21 January 2018

1 reference

Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host

21 January 2018

1 reference

Increased methylation variation in epigenetic domains across cancer types

21 January 2018

1 reference

Genomic insights into cancer-associated aberrant CpG island hypermethylation

21 January 2018

1 reference

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns

21 January 2018

1 reference

Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes

21 January 2018

1 reference

Programming of DNA methylation patterns

21 January 2018

1 reference

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

1 reference

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

21 January 2018

1 reference

A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development

21 January 2018

1 reference

Non-canonical functions of the DNA methylome in gene regulation

21 January 2018

1 reference

xDnmt1 regulates transcriptional silencing in pre-MBT Xenopus embryos independently of its catalytic function

21 January 2018

1 reference

Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.

21 January 2018

1 reference

X inactivation, differentiation, and DNA methylation

21 January 2018

1 reference

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

21 January 2018

1 reference

The colorful history of active DNA demethylation.

21 January 2018

1 reference

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

1 reference

DNA methylation and methylcytosine oxidation in cell fate decisions

21 January 2018

1 reference

5-Hydroxymethylcytosine: generation, fate, and genomic distribution

21 January 2018

1 reference

A new pyrimidine base from bacteriophage nucleic acids

21 January 2018

1 reference

The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid

21 January 2018

1 reference

5-Methylcytosine content in the vertebrate deoxyribonucleic acids: species specificity

21 January 2018

1 reference

The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

21 January 2018

1 reference

The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing

21 January 2018

1 reference

Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA.

21 January 2018

1 reference

5-Hydroxymethylcytosine, the sixth base of the genome

21 January 2018

1 reference

High sensitivity mapping of methylated cytosines

21 January 2018

1 reference

MethyLight: a high-throughput assay to measure DNA methylation

21 January 2018

1 reference

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

21 January 2018

1 reference

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

21 January 2018

1 reference

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

21 January 2018

1 reference

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

21 January 2018

1 reference

The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine

21 January 2018

1 reference

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

21 January 2018

1 reference

Tissue-specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genomes

21 January 2018

1 reference

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

21 January 2018

1 reference

Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution

21 January 2018

1 reference

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.

21 January 2018

1 reference

Base J: Discovery, Biosynthesis, and Possible Functions

21 January 2018

1 reference

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

21 January 2018

1 reference

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity

21 January 2018

1 reference

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation

21 January 2018

1 reference

Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond

21 January 2018

1 reference

S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance

21 January 2018

1 reference

The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

21 January 2018

1 reference

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

21 January 2018

1 reference

Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.

21 January 2018

1 reference

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

21 January 2018

1 reference

Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos

21 January 2018

1 reference

Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain

21 January 2018

1 reference

Regulation of lineage specific DNA hypomethylation in mouse trophectoderm

21 January 2018

1 reference

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

21 January 2018

1 reference

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

1 reference

Genes of the thymidine salvage pathway: thymine-7-hydroxylase from a Rhodotorula glutinis cDNA library and iso-orotate decarboxylase from Neurospora crassa

21 January 2018

1 reference

An unexpectedly high excision capacity for mispaired 5-hydroxymethyluracil in human cell extracts

21 January 2018

1 reference

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

21 January 2018

1 reference

Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

21 January 2018

1 reference

Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming

21 January 2018

1 reference

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.

21 January 2018

1 reference

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.

21 January 2018

1 reference

Active DNA demethylation by oxidation and repair

21 January 2018

1 reference

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase

21 January 2018

1 reference

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

21 January 2018

1 reference

Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics.

21 January 2018

1 reference

Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming

21 January 2018

1 reference

Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.

21 January 2018

1 reference

Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

21 January 2018

1 reference

Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).

21 January 2018

1 reference

Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells

21 January 2018

1 reference

MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

21 January 2018

1 reference

Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives.

21 January 2018

1 reference

Lashings of DNA methylation, forkfuls of chromatin remodeling.

21 January 2018

1 reference

Lsh, a member of the SNF2 family, is required for genome-wide methylation

21 January 2018

1 reference

Genomic mapping of 5-hydroxymethylcytosine in the human brain

21 January 2018

1 reference

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

21 January 2018

1 reference

Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells

21 January 2018

1 reference

Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells

21 January 2018

1 reference

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

21 January 2018

1 reference

Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells

21 January 2018

1 reference

TET2 promotes histone O-GlcNAcylation during gene transcription

21 January 2018

1 reference

5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells

21 January 2018

1 reference

Replication-associated strand asymmetries in mammalian genomes: toward detection of replication origins

21 January 2018

1 reference

Human gene organization driven by the coordination of replication and transcription.

21 January 2018

1 reference

5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations

21 January 2018

1 reference

Global epigenomic reconfiguration during mammalian brain development

21 January 2018

1 reference

Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver.

21 January 2018

1 reference

Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome

21 January 2018

1 reference

Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors

21 January 2018

1 reference

Paradoxical effects of phenobarbital on mouse hepatocarcinogenesis

21 January 2018

1 reference

Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling

21 January 2018

1 reference

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.

21 January 2018

1 reference

DNA hypomethylation in cancer cells

21 January 2018

1 reference

DNA demethylation dynamics

21 January 2018

1 reference

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

21 January 2018

1 reference

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

21 January 2018

1 reference

TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).

21 January 2018

1 reference

TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases

21 January 2018

1 reference

HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.

21 January 2018

1 reference

Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.

21 January 2018

1 reference

Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

21 January 2018

1 reference

Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.

21 January 2018

1 reference

The genomic landscapes of human breast and colorectal cancers

21 January 2018

1 reference

The consensus coding sequences of human breast and colorectal cancers

21 January 2018

1 reference

Diverse somatic mutation patterns and pathway alterations in human cancers

21 January 2018

1 reference

The genomic complexity of primary human prostate cancer

21 January 2018

1 reference

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

21 January 2018

1 reference

Mutation in TET2 in myeloid cancers

21 January 2018

1 reference

Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms

21 January 2018

1 reference

Acquired mutations in TET2 are common in myelodysplastic syndromes

21 January 2018

1 reference

Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML.

21 January 2018

1 reference

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

21 January 2018

1 reference

Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells

21 January 2018

1 reference

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

21 January 2018

1 reference

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

21 January 2018

1 reference

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

21 January 2018

1 reference

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

21 January 2018

1 reference

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

1 reference

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

1 reference

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

21 January 2018

1 reference

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

21 January 2018

1 reference

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

21 January 2018

1 reference

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

21 January 2018

1 reference

Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias

21 January 2018

1 reference

An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

1 reference

IDH1 and IDH2 mutations in gliomas

21 January 2018

1 reference

Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers

21 January 2018

1 reference

Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer

21 January 2018

1 reference

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

21 January 2018

1 reference

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

1 reference

Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors.

21 January 2018

1 reference

Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas

21 January 2018

1 reference

Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma

21 January 2018

1 reference

A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

1 reference

Histone demethylation by a family of JmjC domain-containing proteins

21 January 2018

1 reference

Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

21 January 2018

1 reference

SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma

21 January 2018

1 reference

SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma

21 January 2018

1 reference

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

21 January 2018

1 reference

SDH mutations establish a hypermethylator phenotype in paraganglioma.

21 January 2018

1 reference

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

21 January 2018

1 reference

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 January 2018

1 reference

Genome-wide DNA methylation analysis of archival formalin-fixed paraffin-embedded tissue using the Illumina Infinium HumanMethylation27 BeadChip.

21 January 2018

1 reference

Mechanism and Stem-Cell Activity of 5-Carboxycytosine Decarboxylation Determined by Isotope Tracing

21 January 2018

1 reference

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/EPI.13.69

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24283880%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference