The dual role of Smad7 in the control of cancer growth and metastasis (Q38169545)

30 August 2017

1 reference

8 February 2021

The dual role of Smad7 in the control of cancer growth and metastasis (English)

1 reference

30 August 2017

1 reference

28 November 2019

1 reference

8 February 2021

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24317436%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Irene Marafini

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24317436%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Veronica De Simone

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24317436%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Francesco Pallone

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24317436%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Giovanni Monteleone

5

1 reference

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10 June 2020

language of work or name

English

0 references

publication date

5 December 2013

5 references

International Journal of Molecular Sciences

30 August 2017

3 April 2019

20 November 2019

28 November 2019

8 February 2021

5 references

3 April 2019

20 November 2019

28 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24317436%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

8 February 2021

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24317436%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24317436%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

23774-23790

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24317436%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

10 June 2020

copyright license

4 references

3 April 2019

20 November 2019

28 November 2019

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

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ScienceSource

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6 September 2017

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6 September 2017

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Association of common genetic variants in SMAD7 and risk of colon cancer

6 September 2017

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6 September 2017

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Smad7 is required for the development and function of the heart

6 September 2017

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Smad7 induces hepatic metastasis in colorectal cancer

6 September 2017

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Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

6 September 2017

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Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation

6 September 2017

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A 4.3 kb Smad7 promoter is able to specify gene expression during mouse development

6 September 2017

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Smad7: licensed to kill beta-catenin

6 September 2017

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Smad7 promotes and enhances skeletal muscle differentiation

6 September 2017

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In vivo disruption of TGF-beta signaling by Smad7 leads to premalignant ductal lesions in the pancreas

6 September 2017

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6 September 2017

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Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer

6 September 2017

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Thioredoxin is downstream of Smad7 in a pathway that promotes growth and suppresses cisplatin-induced apoptosis in pancreatic cancer

6 September 2017

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Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection.

6 September 2017

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GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

6 September 2017

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Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3

6 September 2017

1 reference

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Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

6 September 2017

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

6 September 2017

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6 September 2017

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

6 September 2017

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Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells

6 September 2017

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6 September 2017

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6 September 2017

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Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

6 September 2017

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The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

6 September 2017

1 reference

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The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

6 September 2017

1 reference

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Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

TGF-beta signal transduction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

A genetic model for colorectal tumorigenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Tumor invasion and metastasis: an imbalance of positive and negative regulation.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Smad7 expression in T cells prevents colitis-associated cancer.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Smad4 inactivation promotes malignancy and drug resistance of colon cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Smad signaling is required to maintain epigenetic silencing during breast cancer progression.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Nuclear function of Smad7 promotes myogenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Smad4/Smad7 balance: a role of tumorigenesis in gastric cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Smad7 sensitizes tumor necrosis factor induced apoptosis through the inhibition of antiapoptotic gene expression by suppressing activation of the nuclear factor-kappaB pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Deletion of exon I of SMAD7 in mice results in altered B cell responses.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

2-Methoxyestradiol-induced apoptosis in prostate cancer cells requires Smad7.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Smads mediate signaling of the TGFbeta superfamily in normal keratinocytes but are lost during skin chemical carcinogenesis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Smad3 mutant mice develop metastatic colorectal cancer

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Frequency of Smad gene mutations in human cancers.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Stable Overexpression of Smad7 in Human Melanoma Cells Impairs Bone Metastasis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Expression of Smad7 in hepatocellular carcinoma and dysplastic nodules: resistance mechanism to transforming growth factor-beta.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Prognostic significance of the expression of Smad4 and Smad7 in human gastric carcinomas

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3876077

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390%2FIJMS141223774

Prognostic value of the expression of Smad6 and Smad7, as inhibitory Smads of the TGF-beta superfamily, in esophageal squamous cell carcinoma

21 January 2018

1 reference

12 December 2020

Smad7-induced beta-catenin degradation alters epidermal appendage development

1 reference

12 December 2020

Low-level expression of Smad7 correlates with lymph node metastasis and poor prognosis in patients with pancreatic cancer

1 reference

12 December 2020

Differential effect of the expression of TGF-β pathway inhibitors, Smad-7 and Ski, on invasive breast carcinomas: relation to biologic behavior

1 reference

12 December 2020

Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7

1 reference

12 December 2020

SMAD7 is a prognostic marker in patients with colorectal cancer

1 reference

12 December 2020

Homozygous deletion map at 18q21.1 in pancreatic cancer

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS141223774

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24317436%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24317436%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24317436%20AND%20SRC:MED&resulttype=core&format=json