Insights into wild-type and mutant p53 functions provided by genetically engineered mice (Q38177769)

30 August 2017

Insights into wild-type and mutant p53 functions provided by genetically engineered mice (English)

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30 August 2017

Lawrence A Donehower

1

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30 August 2017

5 February 2014

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30 August 2017

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30 August 2017

35

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30 August 2017

6

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30 August 2017

715-727

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Post-translational modifications and activation of p53 by genotoxic stresses

30 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

High-frequency developmental abnormalities in p53-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Telomeres and telomerase in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

A continuum model for tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

The impact of acetylation and deacetylation on the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse embryonic fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Temporal dissection of p53 function in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

The p53-deficient mouse: a model for basic and applied cancer studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Insights into aging obtained from p53 mutant mouse models

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

The coordinate regulation of the p53 and mTOR pathways in cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

The consequence of p53 overexpression for liver tumor development and the response of transformed murine hepatocytes to genotoxic agents.

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Tumor spectrum analysis in p53-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

The mutant p53 mouse as a pre-clinical model

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

p53 N-terminal phosphorylation: a defining layer of complex regulation

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Integrated genomic characterization of endometrial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Mutation and cancer: statistical study of retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

p53, the cellular gatekeeper for growth and division

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Puma is required for p53-induced depletion of adult stem cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

High metastatic potential in mice inheriting a targeted p53 missense mutation

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

The utility of genetically modified mouse assays for identifying human carcinogens: a basic understanding and path forward. The Alternatives to Carcinogenicity Testing Committee ILSI HESI

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Modulation of mammalian life span by the short isoform of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Modeling the therapeutic efficacy of p53 restoration in tumors

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Somatic p16(INK4a) loss accelerates melanomagenesis

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

p53 must be competent for transcriptional regulation to suppress tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

The role of transgenic mouse models in carcinogen identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Mice defective in p53 nuclear localization signal 1 exhibit exencephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Cancer and ageing: convergent and divergent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Phosphorylation of serine 18 regulates distinct p53 functions in mice

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22507

TP53 mutations in human cancer: database reassessment and prospects for the next decade

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Integrated genomic analyses of ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Comprehensive molecular portraits of human breast tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Comprehensive molecular characterization of human colon and rectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Comprehensive genomic characterization of squamous cell lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Telomerase reverse transcriptase delays aging in cancer-resistant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Dual loss of rb1 and Trp53 in the adrenal medulla leads to spontaneous pheochromocytoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

p53 mutant mice that display early ageing-associated phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Live or let die: the cell's response to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Blinded by the Light: The Growing Complexity of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Rapid derivation of genetically related mutants from embryonic cells harboring a recombinase-specific Trp53 platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Efficient introduction of specific TP53 mutations into mouse embryonic fibroblasts and embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

Delayed ageing through damage protection by the Arf/p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

When mutants gain new powers: news from the mutant p53 field.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

7 January 2021

Delayed expression of apoptotic and cell-cycle control genes in carcinogen-exposed bladders of mice lacking p53.S389 phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

7 January 2021

Effects of genetic background on tumorigenesis in p53-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

7 January 2021

20 years studying p53 functions in genetically engineered mice

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

7 January 2021

Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

7 January 2021

The differential effects of mutant p53 alleles on advanced murine lung cancer

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

7 January 2021

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

7 January 2021

Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

7 January 2021

Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

7 January 2021

Cooperative tumorigenic effects of germline mutations in Rb and p53

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22507

7 January 2021

Identifiers

DOI

10.1002/HUMU.22507

1 reference

30 August 2017

1 reference

PubMed ID

24415648