Fibroblast growth factor 21: a promising therapeutic target in obesity-related diseases (Q38201778)

30 August 2017

Fibroblast growth factor 21: a promising therapeutic target in obesity-related diseases (English)

1 reference

30 August 2017

0 references

1

Bernard M Y Cheung

1 reference

30 August 2017

H B Deng

2

1 reference

30 August 2017

3 April 2014

1 reference

Expert Review of Cardiovascular Therapy

30 August 2017

1 reference

30 August 2017

12

1 reference

30 August 2017

6

1 reference

30 August 2017

659-666

1 reference

Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.

30 August 2017

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Identification of a novel FGF, FGF-21, preferentially expressed in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Metabolically protective cytokines adiponectin and fibroblast growth factor-21 are increased by acute overfeeding in healthy humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

FGF-21 as a novel metabolic regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Fibroblast growth factor 21 corrects obesity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

PPARalpha is a key regulator of hepatic FGF21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Exercise increases serum fibroblast growth factor 21 (FGF21) levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

FGF21 and the second coming of PPARγ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

FGF21 N- and C-termini play different roles in receptor interaction and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Understanding the physical interactions in the FGF21/FGFR/β-Klotho complex: structural requirements and implications in FGF21 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Metabolism: Adiponectin---a mediator of specific metabolic actions of FGF21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Thermogenic activation induces FGF21 expression and release in brown adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor γ signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

FGF21 is an Akt-regulated myokine

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Myocardial Akt activation and gender: increased nuclear activity in females versus males

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

The fasting polypeptide FGF21 can enter brain from blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Obesity is a fibroblast growth factor 21 (FGF21)-resistant state

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: a longitudinal analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Effects of short-term continuous subcutaneous insulin infusion on fasting plasma fibroblast growth factor-21 levels in patients with newly diagnosed type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Relationship of serum fibroblast growth factor 21 with abnormal glucose metabolism and insulin resistance: the Baltimore Longitudinal Study of Aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Elevated serum fibroblast growth factor 21 is associated with hypertension in community-dwelling adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Liver fat but not other adiposity measures influence circulating FGF21 levels in healthy young adult twins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Fibroblast growth factor 21 protects against cardiac hypertrophy in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Proteomic study on the protective mechanism of fibroblast growth factor 21 to ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Effects of a three-month combined exercise programme on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Mitiglinide treatment may decreases plasma fibroblast growth factor-21 levels in individuals with new-onset T2DM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

A novel approach to improve the function of FGF21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

Attenuation of FGF signalling in mouse β-cells leads to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.2014.904745

10.1586/14779072.2014.904745

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference

PubMed ID

24697521