Taming inflammation by targeting cytokine signaling: new perspectives in the induction of transplantation tolerance (Q38217596)

31 August 2017

title

Taming inflammation by targeting cytokine signaling: new perspectives in the induction of transplantation tolerance (English)

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31 August 2017

4

Gerald Brandacher

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31 August 2017

Saami Khalifian

1

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31 August 2017

Giorgio Raimondi

series ordinal

2

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31 August 2017

Wp Andrew Lee

series ordinal

3

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31 August 2017

publication date

1 January 2014

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31 August 2017

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31 August 2017

volume

6

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31 August 2017

issue

5

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31 August 2017

page(s)

637-653

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Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death

31 August 2017

cites work

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Life and death in peripheral T cells

21 January 2018

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Mechanisms of tolerance induction through the transplantation of donor hematopoietic stem cells: central versus peripheral tolerance

21 January 2018

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Levels of peripheral T cell tolerance

21 January 2018

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21 January 2018

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21 January 2018

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Naturally occurring regulatory T cells: recent insights in health and disease

21 January 2018

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How regulatory T cells work

21 January 2018

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Cutting edge: allogeneic CD4+CD25+Foxp3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance

21 January 2018

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Phenotypical and functional specialization of FOXP3+ regulatory T cells

21 January 2018

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Regulatory T cells exert checks and balances on self tolerance and autoimmunity

21 January 2018

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Mechanisms of foxp3+ T regulatory cell-mediated suppression

21 January 2018

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The complementary roles of deletion and regulation in transplantation tolerance

21 January 2018

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CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade

21 January 2018

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Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model.

21 January 2018

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FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal.

21 January 2018

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Monocyte chemoattractant protein-1 levels in bronchoalveolar lavage fluid of lung-transplanted patients treated with tacrolimus as rescue treatment for refractory acute rejection.

21 January 2018

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Presence of FoxP3+ regulatory T Cells predicts outcome of subclinical rejection of renal allografts.

21 January 2018

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Immune evasion by chimeric trachea

21 January 2018

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Recent progress and new perspectives in studying T cell responses to allografts

21 January 2018

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Inflammatory cytokines as a third signal for T cell activation

21 January 2018

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Pathways of major histocompatibility complex allorecognition.

21 January 2018

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Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation

21 January 2018

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Costimulatory pathways in transplantation: challenges and new developments.

21 January 2018

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Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

21 January 2018

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CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

21 January 2018

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T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions

21 January 2018

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Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.

21 January 2018

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Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection

21 January 2018

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CTLA-4 is a second receptor for the B cell activation antigen B7

21 January 2018

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CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

21 January 2018

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New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprinting

21 January 2018

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Immunology. Licence to kill

21 January 2018

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A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

21 January 2018

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Recent advances on the role of CD40 and dendritic cells in immunity and tolerance

21 January 2018

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CD40/CD154 interactions at the interface of tolerance and immunity

21 January 2018

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The significance of OX40 and OX40L to T-cell biology and immune disease.

21 January 2018

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Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

21 January 2018

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CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism

21 January 2018

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Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells

21 January 2018

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TNF/TNFR family members in costimulation of T cell responses

21 January 2018

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Differentiation of effector CD4 T cell populations (*)

21 January 2018

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Signals required for programming effector and memory development by CD8+ T cells

21 January 2018

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Shaping and reshaping CD8+ T-cell memory.

21 January 2018

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Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.

21 January 2018

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Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses.

21 January 2018

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Critical role of CD4 help in CD154 blockade-resistant memory CD8 T cell activation and allograft rejection in sensitized recipients

21 January 2018

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IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity

21 January 2018

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IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

21 January 2018

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IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice

21 January 2018

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IL-6 promotes cardiac graft rejection mediated by CD4+ cells

21 January 2018

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The effects of IL-6 on CD4 T cell responses

21 January 2018

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TLR signals promote IL-6/IL-17-dependent transplant rejection.

21 January 2018

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Graft produced interleukin-6 functions as a danger signal and promotes rejection after transplantation.

21 January 2018

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B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes

21 January 2018

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The nature of the lymphopenic environment dictates protective function of homeostatic-memory CD8+ T cells

21 January 2018

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Programming for CD8 T cell memory development requires IL-12 or type I IFN

21 January 2018

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Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function

21 January 2018

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CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion

21 January 2018

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Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

21 January 2018

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IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions

21 January 2018

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Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance

21 January 2018

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CTLA-4 can function as a negative regulator of T cell activation

21 January 2018

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T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo

21 January 2018

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Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure

21 January 2018

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Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade

21 January 2018

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Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection

21 January 2018

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CD28 blockade induces division-dependent downregulation of interleukin-2 receptor alpha

21 January 2018

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CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation.

21 January 2018

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Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation

21 January 2018

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Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts.

21 January 2018

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CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.

21 January 2018

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Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation

21 January 2018

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Effector functions of donor-reactive CD8 memory T cells are dependent on ICOS induced during division in cardiac grafts

21 January 2018

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Blockade of OX40/OX40 ligand to decrease cytokine messenger RNA expression in acute renal allograft rejection in vitro

21 January 2018

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ICOS co-stimulatory receptor is essential for T-cell activation and function

21 January 2018

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Critical, but conditional, role of OX40 in memory T cell-mediated rejection.

21 January 2018

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Molecular mechanisms of T cell co-stimulation and co-inhibition

21 January 2018

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Role of the PD-1 pathway in the immune response

21 January 2018

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The PDL1-PD1 axis converts human TH1 cells into regulatory T cells

21 January 2018

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Programmed death-1 targeting can promote allograft survival

21 January 2018

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Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts.

21 January 2018

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Targeting co-stimulatory pathways: transplantation and autoimmunity

21 January 2018

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The impact of infection and tissue damage in solid-organ transplantation

21 January 2018

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Heterologous immunity provides a potent barrier to transplantation tolerance

21 January 2018

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Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity

21 January 2018

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Superantigens: mechanism of T-cell stimulation and role in immune responses

21 January 2018

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Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model

21 January 2018

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IL-6 and TNF-alpha synergistically inhibit allograft acceptance

21 January 2018

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TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.

21 January 2018

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Rapid conversion of effector mechanisms from NK to T cells during virus-induced lysis of allogeneic implants in vivo

21 January 2018

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CD8 T cell responses to viral infections in sequence

21 January 2018

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Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections

21 January 2018

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Cross-reactivity of cytomegalovirus-specific CD8+ T cells to allo-major histocompatibility complex class I molecules

21 January 2018

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Frontiers in nephrology: heterologous immunity, T cell cross-reactivity, and alloreactivity

21 January 2018

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Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection.

21 January 2018

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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

21 January 2018

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Toll-like receptor signaling in transplantation

21 January 2018

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Regulatory T cells overturned: the effectors fight back

21 January 2018

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Mechanisms underlying blockade of allograft acceptance by TLR ligands

21 January 2018

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Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection

21 January 2018

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Type I interferons are not critical for skin allograft rejection or the generation of donor-specific CD8+ memory T cells.

21 January 2018

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Targeting signal transduction as a strategy to treat inflammatory diseases.

21 January 2018

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A randomized, multicenter, double-blind, placebo-controlled phase 2 trial of ISA247 in patients with chronic plaque psoriasis.

21 January 2018

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mTOR--beyond transplantation

21 January 2018

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Effect of rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway

21 January 2018

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Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses

21 January 2018

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Inhibitors of the mammalian target of rapamycin

21 January 2018

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Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B

21 January 2018

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How Toll-like receptors signal: what we know and what we don't know

21 January 2018

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Interleukin-17 family members and inflammation

21 January 2018

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Control of lymphocyte development by nuclear factor-kappaB.

21 January 2018

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The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

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Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation.

21 January 2018

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Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development

21 January 2018

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A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

21 January 2018

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RDP58 is a novel and potentially effective oral therapy for ulcerative colitis.

21 January 2018

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JAK and STAT signaling molecules in immunoregulation and immune-mediated disease

21 January 2018

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Interpreting mixed signals: the cell's cytokine conundrum

21 January 2018

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Current landscape for T-cell targeting in autoimmunity and transplantation

21 January 2018

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Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

21 January 2018

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The effect of the JAK inhibitor CP-690,550 on peripheral immune parameters in stable kidney allograft patients

21 January 2018

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Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primates

21 January 2018

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Population pharmacokinetic analysis of mycophenolic acid coadministered with either tasocitinib (CP-690,550) or tacrolimus in adult renal allograft recipients

21 January 2018

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Interleukin 2 receptor antagonists for renal transplant recipients: a meta-analysis of randomized trials

21 January 2018

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Meta-analysis of basiliximab for immunoprophylaxis in renal transplantation

21 January 2018

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Tocilizumab for the treatment of steroid refractory graft-versus-host disease

21 January 2018

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Outcomes in African-Americans vs. Caucasians using thymoglobulin or interleukin-2 receptor inhibitor induction: analysis of USRDS database

21 January 2018

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Alemtuzumab induction and prednisone-free maintenance immunotherapy in kidney transplantation: comparison with basiliximab induction--long-term results

21 January 2018

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Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with Thymoglobulin or Campath

21 January 2018

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Early outcomes of thymoglobulin and basiliximab induction in kidney transplantation: application of statistical approaches to reduce bias in observational comparisons

21 January 2018

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Tolerance and chimerism after renal and hematopoietic-cell transplantation

21 January 2018

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HLA-mismatched renal transplantation without maintenance immunosuppression

21 January 2018

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Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation

21 January 2018

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Tolerance induction in HLA disparate living donor kidney transplantation by donor stem cell infusion: durable chimerism predicts outcome

21 January 2018

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Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells

21 January 2018

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Clinical update: immunosuppression minimisation

21 January 2018

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Pretransplant Donor Peripheral Blood Mononuclear Cells Infusion Induces Transplantation Tolerance by Generating Regulatory T Cells

21 January 2018

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Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

21 January 2018

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Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts

21 January 2018

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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/IMT.14.25

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31 August 2017

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