-7/7q- syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity (Q38226741)

31 August 2017

-7/7q- syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity (English)

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31 August 2017

H Honda

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31 August 2017

A Nagamachi

series ordinal

2

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31 August 2017

T Inaba

series ordinal

3

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31 August 2017

language of work or name

English

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publication date

7 July 2014

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https://scigraph.springernature.com/pub.10.1038/onc.2014.196

31 August 2017

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Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines

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Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes

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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

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A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

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Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

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Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease.

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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

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Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse

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Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7

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CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases

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WNT5A--target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer

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Transcription factor CUTL1 is a negative regulator of drug resistance in gastric cancer

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Transgenic mice expressing the p75 CCAAT-displacement protein/Cut homeobox isoform develop a myeloproliferative disease-like myeloid leukemia

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Mouse mammary tumor virus p75 and p110 CUX1 transgenic mice develop mammary tumors of various histologic types

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Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice

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Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids

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Assignment of the human homologue of the Drosophila Cut homeobox gene (CUTL1) to band 7q22 by fluorescence in situ hybridization.

21 January 2018

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Inactivating CUX1 mutations promote tumorigenesis

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Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

21 January 2018

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Enhancer malfunction in cancer

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High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations

21 January 2018

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Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

21 January 2018

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The genetic landscape of the childhood cancer medulloblastoma

21 January 2018

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Identification of genomic alterations in oesophageal squamous cell cancer

21 January 2018

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MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.

21 January 2018

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MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia

21 January 2018

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Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

21 January 2018

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Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells

21 January 2018

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Epigenetics in clinical practice: the examples of azacitidine and decitabine in myelodysplasia and acute myeloid leukemia

21 January 2018

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Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q

21 January 2018

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DOCK4, a GTPase activator, is disrupted during tumorigenesis

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Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.

21 January 2018

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Genomic structure of the PIK3CG gene on chromosome band 7q22 and evaluation as a candidate myeloid tumor suppressor

21 January 2018

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MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia

21 January 2018

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Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22.

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The human Penumbra gene is mapped to a region on chromosome 7 frequently deleted in myeloid malignancies

21 January 2018

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Putative RNA-splicing gene LUC7L2 on 7q34 represents a candidate gene in pathogenesis of myeloid malignancies

21 January 2018

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Frequent pathway mutations of splicing machinery in myelodysplasia

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Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis

21 January 2018

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Cytogenetic abnormalities in a series of 1,029 patients with primary myelodysplastic syndromes: a report from the US with a focus on some undefined single chromosomal abnormalities.

21 January 2018

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Better prognosis for patients with del(7q) than for patients with monosomy 7 in myelodysplastic syndrome.

21 January 2018

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Revised international prognostic scoring system for myelodysplastic syndromes

21 January 2018

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Does MDS with der(1;7)(q10;p10) constitute a distinct risk group? A retrospective single institutional analysis of clinical/pathologic features compared to -7/del(7q) MDS.

21 January 2018

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EVI1 and hematopoietic disorders: history and perspectives

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The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions

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Evi1 forms a bridge between the epigenetic machinery and signaling pathways.

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The role of EVI1 in myeloid malignancies

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Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines

21 January 2018

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RTCGD: retroviral tagged cancer gene database

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Both AML1 and EVI1 oncogenic components are required for the cooperation of AML1/MDS1/EVI1 with BCR/ABL in the induction of acute myelogenous leukemia in mice

21 January 2018

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High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients

21 January 2018

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EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia

21 January 2018

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Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

21 January 2018

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A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a

21 January 2018

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EVI1 recruits the histone methyltransferase SUV39H1 for transcription repression

21 January 2018

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

21 January 2018

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p15Ink4b Functions in determining hematopoietic cell fates: implications for its role as a tumor suppressor

21 January 2018

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Cyclin D-dependent kinases, INK4 inhibitors and cancer

21 January 2018

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Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

21 January 2018

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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

21 January 2018

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

21 January 2018

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p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

21 January 2018

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Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia.

21 January 2018

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p15INK4b methylation correlates with thrombocytopenia, blast percentage, and survival in myelodysplastic syndromes in a dose dependent manner: quantitation using pyrosequencing study

21 January 2018

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Epigenetic changes in therapy-related MDS/AML.

21 January 2018

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The RUNX genes: gain or loss of function in cancer

21 January 2018

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Normal and transforming functions of RUNX1: a perspective

21 January 2018

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RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes

21 January 2018

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A role for RUNX1 in hematopoiesis and myeloid leukemia.

21 January 2018

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Oncogenic potential of the RUNX gene family: 'overview'.

21 January 2018

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

21 January 2018

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

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AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.

21 January 2018

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RUNX1 translocations and fusion genes in malignant hemopathies

21 January 2018

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Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia

21 January 2018

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

21 January 2018

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AML1 mutations induced MDS and MDS/AML in a mouse BMT model

21 January 2018

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 January 2018

1 reference

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Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation

21 January 2018

1 reference

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Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations

21 January 2018

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AML1/RUNX1 gene point mutations in childhood myeloid malignancies

21 January 2018

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RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group

21 January 2018

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RAS, FLT3, and TP53 mutations in therapy-related myeloid malignancies with abnormalities of chromosomes 5 and 7.

21 January 2018

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Cooperation of activating Ras/rtk signal transduction pathway mutations and inactivating myeloid differentiation gene mutations in M0 AML: a study of 45 patients

21 January 2018

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

1 reference

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Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2014.196

SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.196

SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias.

21 January 2018

1 reference

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SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.196

Clinical implications of the SETBP1 mutation in patients with primary myelodysplastic syndrome and its stability during disease progression.

21 January 2018

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Validation of the revised international prognostic scoring system (IPSS-R) in patients with myelodysplastic syndrome: a multicenter study.

21 January 2018

1 reference

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Refractory anemia in childhood: a retrospective analysis of 67 patients with particular reference to monosomy 7.

21 January 2018

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Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation.

21 January 2018

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Results of treatment of children with refractory anaemia with excess blasts (RAEB) and RAEB in transformation (RAEBt) in Great Britain 1990-99.

21 January 2018

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Hematopoietic stem cell transplantation in children and young adults with secondary myelodysplastic syndrome and acute myelogenous leukemia after aplastic anemia

21 January 2018

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Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study

21 January 2018

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Reduced intensity hematopoietic stem-cell transplantation across human leukocyte antigen barriers in a patient with congenital amegakaryocytic thrombocytopenia and monosomy 7.

21 January 2018

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Childhood monosomy 7 revisited.

21 January 2018

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Epigenetic targets in hematopoietic malignancies

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2014.196

Epigenetics of myelodysplastic syndromes

21 January 2018

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Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

21 January 2018

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Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

21 January 2018

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Prolonged survival with improved tolerability in higher-risk myelodysplastic syndromes: azacitidine compared with low dose ara-C.

21 January 2018

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Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation fo

21 January 2018

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In vivo effects of decitabine in myelodysplasia and acute myeloid leukemia: review of cytogenetic and molecular studies

21 January 2018

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Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells

21 January 2018

1 reference

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Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment

21 January 2018

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Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

21 January 2018

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Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia

21 January 2018

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Epigenetic therapies in MDS and AML

21 January 2018

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Genomic impact of transient low-dose decitabine treatment on primary AML cells

21 January 2018

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Recovery of cells with a normal karyotype in a refractory anaemia patient with monosomy 7‐positive cells after long‐term administration of cyclosporin a

21 January 2018

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Pancytopenia presenting with monosomy 7 which disappeared after immunosuppressive therapy.

21 January 2018

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Treatment of children with refractory anemia: the Japanese Childhood MDS Study Group trial (MDS99).

21 January 2018

1 reference

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Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na

21 January 2018

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Treatment of higher risk myelodysplastic syndrome patients unresponsive to hypomethylating agents with ON 01910.Na

21 January 2018

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Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

21 January 2018

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Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

21 January 2018

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

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How I treat newly diagnosed chronic phase CML

21 January 2018

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Pushing the limits of targeted therapy in chronic myeloid leukaemia.

21 January 2018

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Tyrosine kinase targeted treatment of chronic myelogenous leukemia and other myeloproliferative neoplasms

21 January 2018

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Allelic imbalance in 1p, 7q, 9p, 11p, 12q and 16q regions in non-small cell lung carcinoma and its clinical association: a pilot study

21 January 2018

1 reference

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Identifying the molecular signature of the interstitial deletion 7q subgroup of uterine leiomyomata using a paired analysis

21 January 2018

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Mutation and cancer: statistical study of retinoblastoma

21 January 2018

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Haploinsufficiency for tumor suppression: the hazards of being single and living a long time

21 January 2018

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Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way.

21 January 2018

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Tumor suppressor genetics

21 January 2018

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A continuum model for tumour suppression

21 January 2018

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Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

21 January 2018

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Advances in the 5q- syndrome

21 January 2018

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Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation

21 January 2018

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Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies

21 January 2018

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One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

21 January 2018

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One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering

21 January 2018

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The microcosmos of cancer

21 January 2018

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Non-coding RNAs in human disease

21 January 2018

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Epigenetic regulation of microRNAs in cancer: an integrated review of literature

21 January 2018

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High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility

21 January 2018

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DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.

21 January 2018

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Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7. European Working Group on MDS in Childhood (EWOG-MDS)

21 January 2018

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Sole abnormalities of chromosome 7 in myeloid malignancies: spectrum, histopathologic correlates, and prognostic implications

31 March 2020

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Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia-positive chronic myeloid leukemia: Two cases with a different outcome

31 March 2020

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Letter: Deletions of chromosome 7 in haematological disorders

31 March 2020

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Fourth International Workshop on Chromosomes in Leukemia 1982: Abnormalities of chromosome 7 resulting in monosomy 7 or in deletion of the long arm (7q-): review of translocations, breakpoints, and associated abnormalities.

31 March 2020

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Molecular characterization of the 7q deletion in myeloid disorders

31 March 2020

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Recurrent genetic defects on chromosome 7q in myeloid neoplasms

31 March 2020

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Mechanisms of polycomb gene silencing: knowns and unknowns

31 March 2020

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Delineation of multiple deleted regions in 7q in myeloid disorders

31 March 2020

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Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing

31 March 2020

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Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

31 March 2020

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DOCK4 deletion at 7q31.1 in a de novo acute myeloid leukemia with a normal karyotype

31 March 2020

1 reference

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Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes

31 March 2020

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31 March 2020

12 December 2020

Evidence for a direct role of the disease modifier SCNM1 in splicing

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Refined mapping of the region of loss of heterozygosity on the long arm of chromosome 7 in human breast cancer defines the location of a second tumor suppressor gene at 7q22 in the region of the CUTL1 gene

31 March 2020

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New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients

31 March 2020

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Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome

31 March 2020

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EVI1 induces myelodysplastic syndrome in mice

31 March 2020

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Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia

31 March 2020

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High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities

31 March 2020

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Methylation of the p15(INK4B) gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation

31 March 2020

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Aberrant p15 gene promoter methylation in therapy-related myelodysplastic syndrome and acute myeloid leukaemia: clinicopathological and karyotypic associations

31 March 2020

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RUNX1 gene mutation in primary myelodysplastic syndrome--the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome

31 March 2020

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TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

31 March 2020

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Mutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations

31 March 2020

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Monosomy 7 associated with pediatric acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS): successful management by allogeneic hematopoietic stem cell transplant (HSCT)

31 March 2020

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A predictive model for the clinical response to low dose ara-C: a study of 102 patients with myelodysplastic syndromes or acute leukaemia

31 March 2020

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Preferential cytogenetic response to continuous intravenous low-dose decitabine (DAC) administration in myelodysplastic syndrome with monosomy 7

31 March 2020

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CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine

31 March 2020

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Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms

31 March 2020

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Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome

31 March 2020

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Loss of heterozygosity analysis of a candidate gastric carcinoma tumor suppressor locus at 7q31

31 March 2020

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CUX1 in leukemia: dosage matters

31 March 2020

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The many faces of marginal zone lymphoma

31 March 2020

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12 December 2020

Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias

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Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications

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Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells

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Monosomy-7 in childhood hemopoietic disorders

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Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations

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Molecular cytogenetic delineation of deletions and translocations involving chromosome band 7q22 in myeloid leukemias

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p16 gene homozygous deletions in acute lymphoblastic leukemia

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Classification of deletions and identification of cryptic translocations involving 7q by fluorescence in situ hybridization (FISH)

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Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases.

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Hypermethylation of the p15INK4B gene in myelodysplastic syndromes

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Molecular cytogenetic characterization of a critical region in bands 7q35-q36 commonly deleted in malignant myeloid disorders

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The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties

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Myelodysplastic and myeloproliferative disorders of childhood: a study of 167 patients.

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Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

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Mutations of the ras proto-oncogenes in childhood monosomy 7

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Pediatric myelodysplasia: a study of 68 children and a new prognostic scoring system

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Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study

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Chromosome studies in preleukemia. I. Aneuploidy of group C chromosomes in three patients

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International scoring system for evaluating prognosis in myelodysplastic syndromes

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Molecular characterization of chromosome 7 long arm deletions in myeloid disorders

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Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression

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Identifiers

DOI

10.1038/ONC.2014.196

1 reference

Dimensions Publication ID

31 August 2017

0 references

1 reference