Therapeutic targeting of microRNAs: current status and future challenges (Q38228101)

31 August 2017

Therapeutic targeting of microRNAs: current status and future challenges (English)

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31 August 2017

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Zhonghan Li

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author name string

Tariq M Rana

series ordinal

2

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31 August 2017

11 July 2014

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Nature Reviews Drug Discovery

31 August 2017

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31 August 2017

13

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31 August 2017

622-638

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31 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrd4359

31 August 2017

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cites work

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

31 March 2020

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MicroRNAs: genomics, biogenesis, mechanism, and function

31 March 2020

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The functions of animal microRNAs

31 March 2020

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Biogenesis and germline functions of piRNAs

31 March 2020

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Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells

31 March 2020

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MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias

31 March 2020

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Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

31 March 2020

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31 March 2020

miRNAs in human cancer

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MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles.

31 March 2020

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Physiological and pathological roles for microRNAs in the immune system

31 March 2020

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Inhibition of microRNA with antisense oligonucleotides

31 March 2020

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Chemical modification and design of anti-miRNA oligonucleotides.

31 March 2020

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RNAi therapeutics: a potential new class of pharmaceutical drugs

31 March 2020

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Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

31 March 2020

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Silencing of microRNAs in vivo with 'antagomirs'

31 March 2020

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LNA-mediated microRNA silencing in non-human primates

31 March 2020

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Molecular mechanisms of RNA-triggered gene silencing machineries.

31 March 2020

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The widespread regulation of microRNA biogenesis, function and decay

31 March 2020

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Posttranscriptional crossregulation between Drosha and DGCR8.

31 March 2020

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Post-transcriptional control of DGCR8 expression by the Microprocessor

31 March 2020

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The Microprocessor complex mediates the genesis of microRNAs

31 March 2020

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TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

31 March 2020

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RETRACTED: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

31 March 2020

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Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling

31 March 2020

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

31 March 2020

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

31 March 2020

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Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

31 March 2020

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Inhibition of translational initiation by Let-7 MicroRNA in human cells

31 March 2020

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The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

31 March 2020

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Short RNAs repress translation after initiation in mammalian cells.

31 March 2020

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Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR

31 March 2020

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Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

31 March 2020

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Mammalian microRNAs predominantly act to decrease target mRNA levels

31 March 2020

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A role for the P-body component GW182 in microRNA function

31 March 2020

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GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

31 March 2020

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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

31 March 2020

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Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

31 March 2020

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MicroRNAs: target recognition and regulatory functions

31 March 2020

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Identification of Drosophila MicroRNA targets

31 March 2020

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microRNA target predictions across seven Drosophila species and comparison to mammalian targets

31 March 2020

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Inference of miRNA targets using evolutionary conservation and pathway analysis

31 March 2020

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miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

31 March 2020

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Small RNA-mediated regulation of iPS cell generation.

31 March 2020

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MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells

31 March 2020

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The let-7 microRNA represses cell proliferation pathways in human cells

31 March 2020

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MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

31 March 2020

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MicroRNA sponges: progress and possibilities

31 March 2020

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Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

31 March 2020

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A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA

31 March 2020

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In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma

31 March 2020

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Small-molecule inhibitors of microrna miR-21 function

31 March 2020

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Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma

31 March 2020

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Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes

31 March 2020

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Antisense oligonucleotides made of 2'-O-alkylRNA: their properties and applications in RNA biochemistry

31 March 2020

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MODIFIED OLIGONUCLEOTIDES: Synthesis and Strategy for Users

31 March 2020

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Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

31 March 2020

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Advantages of 2'-O-methyl oligoribonucleotide probes for detecting RNA targets

31 March 2020

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Sequence-specific inhibition of small RNA function

31 March 2020

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Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

31 March 2020

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A direct comparison of anti-microRNA oligonucleotide potency.

31 March 2020

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Antisense oligonucleotide pharmacokinetics and metabolism

31 March 2020

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RNAi in human cells: basic structural and functional features of small interfering RNA.

31 March 2020

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siRNA function in RNAi: a chemical modification analysis

31 March 2020

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

31 March 2020

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Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.

31 March 2020

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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

31 March 2020

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Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

31 March 2020

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2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation

31 March 2020

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miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

31 March 2020

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Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

31 March 2020

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Improved targeting of miRNA with antisense oligonucleotides

31 March 2020

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Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing

31 March 2020

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Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids

31 March 2020

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MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells

31 March 2020

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LNA-modified oligonucleotides mediate specific inhibition of microRNA function.

31 March 2020

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LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

31 March 2020

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Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

31 March 2020

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Silencing of microRNA families by seed-targeting tiny LNAs

31 March 2020

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Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier

31 March 2020

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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

31 March 2020

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Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

31 March 2020

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In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

31 March 2020

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Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer

31 March 2020

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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

31 March 2020

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Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

31 March 2020

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RNAi-mediated gene silencing in non-human primates.

31 March 2020

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

31 March 2020

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Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

31 March 2020

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Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target

31 March 2020

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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

31 March 2020

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A single siRNA suppresses fatal encephalitis induced by two different flaviviruses

31 March 2020

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Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer

31 March 2020

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Nanoparticle therapeutics: an emerging treatment modality for cancer

31 March 2020

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Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

31 March 2020

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Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.

31 March 2020

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Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

31 March 2020

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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

31 March 2020

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Design and creation of new nanomaterials for therapeutic RNAi

31 March 2020

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Silencing microRNA by interfering nanoparticles in mice

31 March 2020

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Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

31 March 2020

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Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

31 March 2020

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T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice

31 March 2020

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Targeted inhibition of HBV gene expression by single-chain antibody mediated small interfering RNA delivery

31 March 2020

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miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements

31 March 2020

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Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development

31 March 2020

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Local dystrophin restoration with antisense oligonucleotide PRO051

31 March 2020

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

31 March 2020

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Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

31 March 2020

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

31 March 2020

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

31 March 2020

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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

31 March 2020

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Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

31 March 2020

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

31 March 2020

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Immunostimulatory potential of silencing RNAs can be mediated by a non-uridine-rich toll-like receptor 7 motif.

31 March 2020

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RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform

31 March 2020

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Inhibition of coagulation by a phosphorothioate oligonucleotide.

31 March 2020

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A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys

31 March 2020

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Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

31 March 2020

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Chemical modification study of antisense gapmers

31 March 2020

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Comparison of hepatic transcription profiles of locked ribonucleic acid antisense oligonucleotides: evidence of distinct pathways contributing to non-target mediated toxicity in mice.

31 March 2020

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Targeting microRNAs in cancer: rationale, strategies and challenges

31 March 2020

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Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92

31 March 2020

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Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters

31 March 2020

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MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation

31 March 2020

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Delivery of molecular and cellular medicine to solid tumors

31 March 2020

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Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape

31 March 2020

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Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA

31 March 2020

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Discovering the first microRNA-targeted drug

31 March 2020

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MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

31 March 2020

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First microRNA mimic enters clinic

31 March 2020

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

31 March 2020

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Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival

31 March 2020

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RAS is regulated by the let-7 microRNA family

31 March 2020

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Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation

31 March 2020

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Suppression of non-small cell lung tumor development by the let-7 microRNA family

31 March 2020

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The let-7 microRNA reduces tumor growth in mouse models of lung cancer

31 March 2020

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let-7 regulates self renewal and tumorigenicity of breast cancer cells

31 March 2020

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A microRNA expression signature of human solid tumors defines cancer gene targets

31 March 2020

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Causes and consequences of microRNA dysregulation in cancer

31 March 2020

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MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

31 March 2020

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MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).

31 March 2020

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MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

31 March 2020

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Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells

31 March 2020

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Control of stress-dependent cardiac growth and gene expression by a microRNA

31 March 2020

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Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure

31 March 2020

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MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes

31 March 2020

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Inhibition of miR-15 protects against cardiac ischemic injury

31 March 2020

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Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family.

31 March 2020

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MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma

31 March 2020

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MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality

31 March 2020

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miR-221 overexpression contributes to liver tumorigenesis

31 March 2020

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miR-221 silencing blocks hepatocellular carcinoma and promotes survival

31 March 2020

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MicroRNAs 103 and 107 regulate insulin sensitivity

31 March 2020

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Transcriptional control of gene expression by microRNAs

31 March 2020

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miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts

31 March 2020

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microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer

31 March 2020

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From pseudo-ceRNAs to circ-ceRNAs: a tale of cross-talk and competition

31 March 2020

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Autoregulation of microRNA biogenesis by let-7 and Argonaute

31 March 2020

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Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons

31 March 2020

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Glycogen synthase kinase 3 beta (GSK3β) phosphorylates the RNAase III enzyme Drosha at S300 and S302

31 March 2020

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Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2.

31 March 2020

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Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

31 March 2020

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Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA

31 March 2020

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Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol

31 March 2020

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12 December 2020

Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis

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12 December 2020

Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey

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12 December 2020

PRO-051, an antisense oligonucleotide for the potential treatment of Duchenne muscular dystrophy.

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12 December 2020

MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways

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12 December 2020

Identifiers

DOI

10.1038/NRD4359

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31 August 2017

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PubMed ID

25011539