Regulation of RIG-I-like receptor signaling by host and viral proteins (Q38229327)

31 August 2017

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22 August 2022

Regulation of RIG-I-like receptor signaling by host and viral proteins (English)

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31 August 2017

1

Jessica J Chiang

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12 June 2020

author name string

Meredith E Davis

series ordinal

2

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12 June 2020

Michaela U Gack

series ordinal

3

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12 June 2020

publication date

21 June 2014

1 reference

PubMed ID

25023063

Cytokine and Growth Factor Reviews

31 August 2017

1 October 2014

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22 August 2022

2 references

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12 June 2020

22 August 2022

25

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12 June 2020

page(s)

491-505

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12 June 2020

issue

5

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Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures

12 June 2020

cites work

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12 December 2020

Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.

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12 December 2020

A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity

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12 December 2020

Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities

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12 December 2020

Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus

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12 December 2020

Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling

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12 December 2020

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo

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12 December 2020

Master sensors of pathogenic RNA - RIG-I like receptors

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12 December 2020

A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2

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12 December 2020

The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

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12 December 2020

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

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12 December 2020

Protein phosphatase 1--targeted in many directions

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12 December 2020

An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

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12 December 2020

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

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12 December 2020

The Atg5 Atg12 conjugate associates with innate antiviral immune responses

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12 December 2020

Kaposi's sarcoma-associated herpesvirus encodes a viral deubiquitinase

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12 December 2020

Structural Insights into RNA Recognition by RIG-I

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12 December 2020

The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors

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12 December 2020

Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses

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12 December 2020

Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex.

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12 December 2020

Mechanism of mda-5 Inhibition by paramyxovirus V proteins.

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12 December 2020

MDA-5 is cleaved in poliovirus-infected cells

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12 December 2020

USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors

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12 December 2020

The thermodynamic basis for viral RNA detection by the RIG-I innate immune sensor

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12 December 2020

NLRX1 is a regulator of mitochondrial antiviral immunity

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12 December 2020

Cell type-specific involvement of RIG-I in antiviral response

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12 December 2020

Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist

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12 December 2020

VISA is an adapter protein required for virus-triggered IFN-beta signaling

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12 December 2020

Mitofusin 2 inhibits mitochondrial antiviral signaling

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12 December 2020

Structural Analysis of a Viral Ovarian Tumor Domain Protease from the Crimean-Congo Hemorrhagic Fever Virus in Complex with Covalently Bonded Ubiquitin

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12 December 2020

NLRX1/NOD5 deficiency does not affect MAVS signalling

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12 December 2020

Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter

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12 December 2020

Pattern recognition receptors and inflammation

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12 December 2020

Cytosolic sensing of viruses

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12 December 2020

Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis

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12 December 2020

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

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12 December 2020

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

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12 December 2020

USP4 positively regulates RIG-I-mediated antiviral response through deubiquitination and stabilization of RIG-I.

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12 December 2020

Mechanisms of RIG-I-like receptor activation and manipulation by viral pathogens

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12 December 2020

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

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12 December 2020

Induction and evasion of type I interferon responses by influenza viruses

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12 December 2020

Respiratory syncytial virus mechanisms to interfere with type 1 interferons

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12 December 2020

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

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12 December 2020

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques

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12 December 2020

Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response

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12 December 2020

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

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12 December 2020

Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses

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12 December 2020

Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein

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12 December 2020

Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme

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12 December 2020

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

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12 December 2020

A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses

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12 December 2020

Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome

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12 December 2020

Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS

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12 December 2020

In vivo ligands of MDA5 and RIG-I in measles virus-infected cells

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12 December 2020

Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling

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12 December 2020

Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling

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12 December 2020

MDA5 is SUMOylated by PIAS2β in the upregulation of type I interferon signaling

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12 December 2020

Hepatitis A virus inhibits cellular antiviral defense mechanisms induced by double-stranded RNA

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12 December 2020

RAVER1 is a coactivator of MDA5-mediated cellular antiviral response.

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12 December 2020

Adenovirus virus-associated RNAs induce type I interferon expression through a RIG-I-mediated pathway

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12 December 2020

The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection

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12 December 2020

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

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12 December 2020

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

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12 December 2020

Peroxisomes are signaling platforms for antiviral innate immunity

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12 December 2020

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

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12 December 2020

Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation

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12 December 2020

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity

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12 December 2020

Human metapneumovirus glycoprotein G inhibits innate immune responses

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12 December 2020

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production

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12 December 2020

The leader proteinase of foot-and-mouth disease virus negatively regulates the type I interferon pathway by acting as a viral deubiquitinase

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12 December 2020

Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I

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12 December 2020

Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor

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12 December 2020

Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.

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12 December 2020

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

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12 December 2020

Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection

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12 December 2020

Conventional protein kinase C-α (PKC-α) and PKC-β negatively regulate RIG-I antiviral signal transduction

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12 December 2020

Phosphorylation-mediated negative regulation of RIG-I antiviral activity

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12 December 2020

Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction

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12 December 2020

The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation

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12 December 2020

Human metapneumovirus glycoprotein G disrupts mitochondrial signaling in airway epithelial cells

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12 December 2020

Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5

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12 December 2020

Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling

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12 December 2020

NLRX1 does not inhibit MAVS-dependent antiviral signalling.

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12 December 2020

Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists

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12 December 2020

mda-5, but not RIG-I, is a common target for paramyxovirus V proteins.

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12 December 2020

The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25

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12 December 2020

The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.

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12 December 2020

The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response

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12 December 2020

Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling

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12 December 2020

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

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12 December 2020

COX5B regulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS production

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12 December 2020

MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells.

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12 December 2020

Both RIG-I and MDA5 RNA Helicases Contribute to the Induction of Alpha/Beta Interferon in Measles Virus-Infected Human Cells

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12 December 2020

Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation

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12 December 2020

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction

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12 December 2020

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

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12 December 2020

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I

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12 December 2020

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

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12 December 2020

The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response

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12 December 2020

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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12 December 2020

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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12 December 2020

Viral degradasome hijacks mitochondria to suppress innate immunity

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12 December 2020

Silencing STATs: lessons from paramyxovirus interferon evasion

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12 December 2020

The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity

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12 December 2020

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

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12 December 2020

Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses

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12 December 2020

Defining the functional determinants for RNA surveillance by RIG-I

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12 December 2020

Enterovirus 2Apro targets MDA5 and MAVS in infected cells

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12 December 2020

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

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12 December 2020

Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64.

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12 December 2020

Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125

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12 December 2020

Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling

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12 December 2020

Cleavage of IPS-1 in cells infected with human rhinovirus.

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12 December 2020

Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling

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12 December 2020

MDA5 assembles into a polar helical filament on dsRNA.

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12 December 2020

MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA

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12 December 2020

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

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12 December 2020

Activation of RIG-I-like receptor signal transduction

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12 December 2020

RIG-I is cleaved during picornavirus infection

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12 December 2020

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

1 reference

12 December 2020

Mitochondria in innate immune responses

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12 December 2020

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

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12 December 2020

Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria

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12 December 2020

Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus

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12 December 2020

Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein

1 reference

12 December 2020

Biological roles and functional mechanisms of arenavirus Z protein in viral replication

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12 December 2020

TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity

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12 December 2020

Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase

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12 December 2020

Differential IFN-alpha/beta production suppressing capacities of the leader proteins of mengovirus and foot-and-mouth disease virus.

1 reference

12 December 2020

Amino acid requirements for MDA5 and LGP2 recognition by paramyxovirus V proteins: a single arginine distinguishes MDA5 from RIG-I.

1 reference

12 December 2020

NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways

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12 December 2020

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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12 December 2020

Themes and variations on ubiquitylation

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12 December 2020

Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction

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12 December 2020

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

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12 December 2020

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

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12 December 2020

Activation of MDA5 requires higher-order RNA structures generated during virus infection

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12 December 2020

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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12 December 2020

Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments

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12 December 2020

The regulation of type I interferon production by paramyxoviruses.

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12 December 2020

NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways

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12 December 2020

Hepatitis A virus suppresses RIG-I-mediated IRF-3 activation to block induction of beta interferon

1 reference

12 December 2020

Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.

1 reference

12 December 2020

GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS

1 reference

12 December 2020

Immune signaling by RIG-I-like receptors

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12 December 2020

MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation

1 reference

12 December 2020

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

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12 December 2020

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

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12 December 2020

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

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12 December 2020

UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS.

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12 December 2020

Phosphorylation of RIG-I by casein kinase II inhibits its antiviral response.

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12 December 2020

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

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12 December 2020

Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production

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12 December 2020

The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.

1 reference

12 December 2020

Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling

1 reference

12 December 2020

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

1 reference

12 December 2020

Multifunctional nature of the arenavirus RING finger protein Z.

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12 December 2020

Viral evasion and subversion of pattern-recognition receptor signalling

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12 December 2020

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

1 reference

12 December 2020

Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.

1 reference

12 December 2020

MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response

1 reference

12 December 2020

Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5.

1 reference

12 December 2020

Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1

1 reference

12 December 2020

Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1

1 reference

12 December 2020

10.1016/J.CYTOGFR.2014.06.005

Identifiers

DOI

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12 June 2020

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12 June 2020

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