Master sensors of pathogenic RNA - RIG-I like receptors (Q38125018)

29 August 2017

Master sensors of pathogenic RNA - RIG-I like receptors (English)

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29 August 2017

1

Martin Schlee

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29 August 2017

1 July 2013

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29 August 2017

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29 August 2017

218

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29 August 2017

1322-1335

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29 August 2017

11

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RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells

29 August 2017

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12 December 2020

Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3

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12 December 2020

Circular forms of Uukuniemi virion RNA: an electron microscopic study

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12 December 2020

Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling

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12 December 2020

Activation of the beta interferon promoter by unnatural Sendai virus infection requires RIG-I and is inhibited by viral C proteins

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12 December 2020

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

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12 December 2020

Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle

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12 December 2020

Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon

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12 December 2020

5'-terminal cap structure in eucaryotic messenger ribonucleic acids.

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12 December 2020

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

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12 December 2020

Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells

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12 December 2020

Structural Insights into RNA Recognition by RIG-I

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12 December 2020

Paramyxovirus ultrastructure and genome packaging: cryo-electron tomography of sendai virus

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12 December 2020

Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses

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12 December 2020

Unpaired 5' ppp-nucleotides, as found in arenavirus double-stranded RNA panhandles, are not recognized by RIG-I

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12 December 2020

Isolation and characterization of Sendai virus DI-RNAs

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12 December 2020

Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling

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12 December 2020

Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes

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12 December 2020

The thermodynamic basis for viral RNA detection by the RIG-I innate immune sensor

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12 December 2020

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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12 December 2020

Short double-stranded RNAs with an overhanging 5' ppp-nucleotide, as found in arenavirus genomes, act as RIG-I decoys

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12 December 2020

Infectious defective interfering particles of VSV from transcripts of a cDNA clone

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12 December 2020

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

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12 December 2020

Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5

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12 December 2020

Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate

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12 December 2020

Conformational flexibility in recombinant measles virus nucleocapsids visualised by cryo-negative stain electron microscopy and real-space helical reconstruction

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12 December 2020

Cell type-specific involvement of RIG-I in antiviral response

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12 December 2020

Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response

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12 December 2020

Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication

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12 December 2020

VISA is an adapter protein required for virus-triggered IFN-beta signaling

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12 December 2020

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

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12 December 2020

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

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12 December 2020

A Toll-like receptor recognizes bacterial DNA

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12 December 2020

Pattern recognition receptors and inflammation

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12 December 2020

The 5' ends of Hantaan virus (Bunyaviridae) RNAs suggest a prime-and-realign mechanism for the initiation of RNA synthesis

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12 December 2020

Analysis of the 5' end structure of HCV subgenomic RNA replicated in a Huh7 cell line

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12 December 2020

When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA.

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12 December 2020

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

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12 December 2020

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

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12 December 2020

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

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12 December 2020

5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

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12 December 2020

Determination of preferential binding sites for anti-dsRNA antibodies on double-stranded RNA by scanning force microscopy

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12 December 2020

The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA

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12 December 2020

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

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12 December 2020

Rig-I-/- mice develop colitis associated with downregulation of G alpha i2.

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12 December 2020

Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response

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12 December 2020

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

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12 December 2020

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

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12 December 2020

Mouse hepatitis virus does not induce Beta interferon synthesis and does not inhibit its induction by double-stranded RNA.

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12 December 2020

Stabilization of circular rpsT mRNA demonstrates the 5'-end dependence of RNase E action in vivo

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12 December 2020

The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.

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12 December 2020

Cellular La protein shields nonsegmented negative-strand RNA viral leader RNA from RIG-I and enhances virus growth by diverse mechanisms.

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12 December 2020

5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops

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12 December 2020

The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection

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12 December 2020

Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling

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12 December 2020

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

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12 December 2020

Distribution of 5'-triphosphate termini on the mRNA of Escherichia coli

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12 December 2020

Adenovirus virus-associated RNAs induce type I interferon expression through a RIG-I-mediated pathway

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12 December 2020

Inverted Complementary Terminal Sequences in Single-Stranded RNAs and Snap-Back RNAs from Vesicular Stomatitis Defective Interfering Particles

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12 December 2020

Activation of IFN-β expression by a viral mRNA through RNase L and MDA5

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12 December 2020

Epstein-Barr virus-encoded small RNA induces IL-10 through RIG-I-mediated IRF-3 signaling

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12 December 2020

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

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12 December 2020

Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis

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12 December 2020

Sendai virus defective-interfering genomes and the activation of interferon-beta

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12 December 2020

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

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12 December 2020

RIG-I detects viral genomic RNA during negative-strand RNA virus infection

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12 December 2020

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

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12 December 2020

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

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12 December 2020

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

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12 December 2020

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

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12 December 2020

Beyond double-stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids

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12 December 2020

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity

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12 December 2020

A protein covalently linked to poliovirus genome RNA

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12 December 2020

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.

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12 December 2020

The nature of the principal type 1 interferon-producing cells in human blood

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12 December 2020

c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response

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12 December 2020

Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction

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12 December 2020

2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo

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12 December 2020

Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses

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12 December 2020

Recognition of mRNA cap structures by viral and cellular proteins

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12 December 2020

Self-coded 3'-extension of run-off transcripts produces aberrant products during in vitro transcription with T7 RNA polymerase

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12 December 2020

Cytoplasmic Listeria monocytogenes stimulates IFN-beta synthesis without requiring the adapter protein MAVS.

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12 December 2020

The origins of defective interfering particles of the negative-strand RNA viruses

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12 December 2020

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids

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12 December 2020

Highly pathogenic RNA viral infections: challenges for antiviral research.

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12 December 2020

Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5

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12 December 2020

Type I interferon production enhances susceptibility to Listeria monocytogenes infection

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12 December 2020

MDA-5 recognition of a murine norovirus

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12 December 2020

Polynucleotide phosphorylase: structure and mechanism of action

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12 December 2020

mda-5, but not RIG-I, is a common target for paramyxovirus V proteins.

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12 December 2020

EBV the prototypical human tumor virus--just how bad is it?

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12 December 2020

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

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12 December 2020

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

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12 December 2020

A structure-based model of RIG-I activation

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12 December 2020

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

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12 December 2020

MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells.

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12 December 2020

Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR

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12 December 2020

Protein-primed and de novo initiation of RNA synthesis by norovirus 3Dpol

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12 December 2020

Cytosolic 5'-triphosphate ended viral leader transcript of measles virus as activator of the RIG I-mediated interferon response

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12 December 2020

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I

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12 December 2020

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

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12 December 2020

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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12 December 2020

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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12 December 2020

Influence of cationic molecules on the hairpin to duplex equilibria of self-complementary DNA and RNA oligonucleotides

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12 December 2020

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

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12 December 2020

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

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12 December 2020

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

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12 December 2020

The ends of La Crosse virus genome and antigenome RNAs within nucleocapsids are base paired

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12 December 2020

Triggering the interferon antiviral response through an IKK-related pathway

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12 December 2020

Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I).

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12 December 2020

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

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12 December 2020

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

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12 December 2020

The specific and essential role of MAVS in antiviral innate immune responses

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12 December 2020

Visualization of Double-Stranded RNA in Cells Supporting Hepatitis C Virus RNA Replication

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12 December 2020

Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase

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12 December 2020

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA

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12 December 2020

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

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12 December 2020

Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA.

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12 December 2020

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

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12 December 2020

The 3' and 5'-terminal sequences of influenza A, B and C virus RNA segments are highly conserved and show partial inverted complementarity

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12 December 2020

RIG-I is cleaved during picornavirus infection

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12 December 2020

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

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12 December 2020

siRNA and isRNA: two edges of one sword

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12 December 2020

Murine coronavirus induces type I interferon in oligodendrocytes through recognition by RIG-I and MDA5.

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12 December 2020

Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia

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12 December 2020

Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways

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12 December 2020

RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.

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12 December 2020

IRF3 mediates a TLR3/TLR4-specific antiviral gene program

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12 December 2020

Duplex RNA activated ATPases (DRAs): platforms for RNA sensing, signaling and processing

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12 December 2020

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

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12 December 2020

Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila

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12 December 2020

RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2

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12 December 2020

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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12 December 2020

Encephalomyocarditis virus RNA. III. Presence of a genome-associated protein

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12 December 2020

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

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12 December 2020

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

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12 December 2020

Activation of MDA5 requires higher-order RNA structures generated during virus infection

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12 December 2020

Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes

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12 December 2020

5'-Triphosphate RNA is the ligand for RIG-I

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12 December 2020

Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly

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12 December 2020

RNA template-directed RNA synthesis by T7 RNA polymerase

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12 December 2020

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

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12 December 2020

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

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12 December 2020

The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness

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12 December 2020

Initiation of RNA decay in Escherichia coli by 5' pyrophosphate removal

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12 December 2020

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

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12 December 2020

Small self-RNA generated by RNase L amplifies antiviral innate immunity

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12 December 2020

Accessing the therapeutic potential of immunostimulatory nucleic acids

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12 December 2020

The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal.

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12 December 2020

A 5'-terminal stem-loop structure can stabilize mRNA in Escherichia coli

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12 December 2020

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

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12 December 2020

Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5

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12 December 2020

Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori

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12 December 2020

Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses

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12 December 2020

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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12 December 2020

CpG motifs in bacterial DNA trigger direct B-cell activation

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12 December 2020

Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1

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12 December 2020

Interplay between innate immunity and negative-strand RNA viruses: towards a rational model

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12 December 2020

The chase for the RIG-I ligand--recent advances

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12 December 2020

10.1016/J.IMBIO.2013.06.007

Identifiers

DOI

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29 August 2017

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PubMed ID

23896194