OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids (Q38230646)

31 August 2017

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids (English)

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31 August 2017

4

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12 June 2020

Veit Hornung

series ordinal

1

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12 June 2020

Rune Hartmann

series ordinal

2

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12 June 2020

3

Andrea Ablasser

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12 June 2020

publication date

18 July 2014

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Nature Reviews Immunology

31 August 2017

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12 June 2020

volume

14

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12 June 2020

page(s)

521-528

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12 June 2020

issue

8

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https://scigraph.springernature.com/pub.10.1038/nri3719

12 June 2020

exact match

0 references

cites work

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Cytosolic sensing of viruses

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Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity

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Constitutive expression of (2'-5') oligo A synthetase confers resistance to picornavirus infection.

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Differential regulation of the OASL and OAS1 genes in response to viral infections

21 January 2018

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A diverse range of gene products are effectors of the type I interferon antiviral response

21 January 2018

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Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor

21 January 2018

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OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7.

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Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response

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Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

21 January 2018

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The role of 2'-5' oligoadenylate-activated ribonuclease L in apoptosis

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Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

21 January 2018

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Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response

21 January 2018

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The large form of human 2',5'-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus

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Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity

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Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology

21 January 2018

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Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L

21 January 2018

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A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.

21 January 2018

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A Toll-like receptor recognizes bacterial DNA

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Nucleic acid recognition by the innate immune system

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Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways

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A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

21 January 2018

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RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

21 January 2018

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RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

21 January 2018

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 January 2018

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ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

21 January 2018

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The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

21 January 2018

1 reference

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

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STING is a direct innate immune sensor of cyclic di-GMP

21 January 2018

1 reference

The structural basis for the sensing and binding of cyclic di-GMP by STING

21 January 2018

1 reference

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

21 January 2018

1 reference

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

21 January 2018

1 reference

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

21 January 2018

1 reference

Cyclic di-GMP sensing via the innate immune signaling protein STING

21 January 2018

1 reference

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

21 January 2018

1 reference

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 January 2018

1 reference

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

21 January 2018

1 reference

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

21 January 2018

1 reference

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

21 January 2018

1 reference

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

21 January 2018

1 reference

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

21 January 2018

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Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

21 January 2018

1 reference

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

21 January 2018

1 reference

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

21 January 2018

1 reference

Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway

21 January 2018

1 reference

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

21 January 2018

1 reference

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

21 January 2018

1 reference

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

21 January 2018

1 reference

Nucleic acid driven sterile inflammation

21 January 2018

1 reference

Trex1 prevents cell-intrinsic initiation of autoimmunity

21 January 2018

1 reference

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease

21 January 2018

1 reference

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

21 January 2018

1 reference

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

21 January 2018

1 reference

Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens

21 January 2018

1 reference

Structural mechanism of cytosolic DNA sensing by cGAS

21 January 2018

1 reference

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

21 January 2018

1 reference

Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS

21 January 2018

1 reference

Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase

21 January 2018

1 reference

A story with a good ending: tRNA 3'-end maturation by CCA-adding enzymes

21 January 2018

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Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence

21 January 2018

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Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates

21 January 2018

1 reference

Structural basis of activity and allosteric control of diguanylate cyclase

21 January 2018

1 reference

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

21 January 2018

1 reference

Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1

21 January 2018

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Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

21 January 2018

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DNA polymerases: structural diversity and common mechanisms

21 January 2018

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Gene structure and function of the 2'-5'-oligoadenylate synthetase family.

21 January 2018

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STING recognition of cytoplasmic DNA instigates cellular defense

21 January 2018

1 reference

Synthesis and Breakdown of pppA2'p5'A2'p5'A and Transient Inhibition of Protein Synthesis in Extracts from Interferon-Treated and Control Cells

21 January 2018

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An interferon-induced phosphodiesterase degrading (2'-5') oligoisoadenylate and the C-C-A terminus of tRNA

21 January 2018

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Metabolic stability of 2′ 5′oligo (A) and activity of 2′ 5′oligo (A)-dependent endonuclease in extracts of interferon-treated and control HeLa cells

21 January 2018

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Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid

21 January 2018

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Bacterial c-di-GMP is an immunostimulatory molecule

21 January 2018

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Cyclic di-GMP stimulates protective innate immunity in bacterial pneumonia

21 January 2018

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The novel cyclic dinucleotide 3'-5' cyclic diguanylic acid binds to p21ras and enhances DNA synthesis but not cell replication in the Molt 4 cell line

21 January 2018

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DNA polymerase beta belongs to an ancient nucleotidyltransferase superfamily.

21 January 2018

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21 January 2018

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Enzymatically active 2',5'-oligoadenylate synthetases are widely distributed among Metazoa, including protostome lineage

21 January 2018

1 reference

2'-5' oligoadenylate synthetase shares active site architecture with the archaeal CCA-adding enzyme

21 January 2018

1 reference

Type I interferonopathies: a novel set of inborn errors of immunity

21 January 2018

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DNA released from dying host cells mediates aluminum adjuvant activity

21 January 2018

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Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts

21 January 2018

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A bipartite model of 2-5A-dependent RNase L

21 January 2018

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Up-regulation of the expression of major histocompatibility complex class I antigens by plasmid DNA transfection in non-hematopoietic cells

31 March 2020

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A unified polymerase mechanism for nonhomologous DNA and RNA polymerases

31 March 2020

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Effects of varying lengths of double-stranded RNA on binding and activation of 2'-5'-oligoadenylate synthetase

31 March 2020

1 reference

Lipofection indirectly increases expression of endogenous major histocompatibility complex class I molecules on tumor cells

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25033909

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI3719

1 reference

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Dimensions Publication ID

12 June 2020

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12 June 2020

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