Assembly and localization of Toll-like receptor signalling complexes. (Q38233769)

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10 March 2020

title

Assembly and localization of Toll-like receptor signalling complexes (English)

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10 March 2020

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3

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10 March 2020

author name string

Nicholas J Gay

series ordinal

1

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10 March 2020

Martyn F Symmons

series ordinal

2

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10 March 2020

Clare E Bryant

series ordinal

4

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publication date

1 August 2014

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Nature Reviews Immunology

10 March 2020

published in

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volume

14

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issue

8

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10 March 2020

page(s)

546-558

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Approaching the asymptote? Evolution and revolution in immunology

10 March 2020

cites work

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Structure and function of Toll receptors and their ligands

31 March 2020

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Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer

31 March 2020

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Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

31 March 2020

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Structural basis of TLR5-flagellin recognition and signaling

31 March 2020

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MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

31 March 2020

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Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa

31 March 2020

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Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

31 March 2020

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

31 March 2020

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

31 March 2020

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Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands

31 March 2020

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Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

31 March 2020

1 reference

Conserved features in the extracellular domain of human toll-like receptor 8 are essential for pH-dependent signaling

31 March 2020

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Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner.

31 March 2020

1 reference

Characterizing the protonation state of cytosine in transient G·C Hoogsteen base pairs in duplex DNA.

31 March 2020

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Rational design of immunostimulatory siRNAs.

31 March 2020

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Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.

31 March 2020

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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

31 March 2020

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Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

31 March 2020

1 reference

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

31 March 2020

1 reference

Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure

31 March 2020

1 reference

Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation

31 March 2020

1 reference

Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle.

31 March 2020

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Structure of toll-like receptors

31 March 2020

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The ectodomain of the Toll-like receptor 4 prevents constitutive receptor activation

31 March 2020

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Conformational coupling across the plasma membrane in activation of the EGF receptor

31 March 2020

1 reference

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

31 March 2020

1 reference

Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from the Brucella Protein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry

31 March 2020

1 reference

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

31 March 2020

1 reference

The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer

31 March 2020

1 reference

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

31 March 2020

1 reference

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

31 March 2020

1 reference

Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling

31 March 2020

1 reference

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

31 March 2020

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Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.

31 March 2020

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Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88

31 March 2020

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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

31 March 2020

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The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

31 March 2020

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31 March 2020

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A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins

31 March 2020

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Cutting Edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs.

31 March 2020

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TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules.

31 March 2020

1 reference

Different dimerisation mode for TLR4 upon endosomal acidification?

31 March 2020

1 reference

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

31 March 2020

1 reference

Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population

31 March 2020

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Pyogenic bacterial infections in humans with MyD88 deficiency

31 March 2020

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Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

31 March 2020

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Targeting TLR4 signaling by TLR4 Toll/IL-1 receptor domain-derived decoy peptides: identification of the TLR4 Toll/IL-1 receptor domain dimerization interface.

31 March 2020

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Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain.

31 March 2020

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An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88.

31 March 2020

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The TLR3 signaling complex forms by cooperative receptor dimerization

31 March 2020

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An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.

31 March 2020

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Toll-like receptors as molecular switches.

31 March 2020

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Helical assembly in the death domain (DD) superfamily

31 March 2020

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The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.

31 March 2020

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MyD88, an adapter protein involved in interleukin-1 signaling

31 March 2020

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What the Myddosome structure tells us about the initiation of innate immunity

31 March 2020

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Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

31 March 2020

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Dynamically driven protein allostery.

31 March 2020

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Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

31 March 2020

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The role of intermediary domain of MyD88 in cell activation and therapeutic inhibition of TLRs.

31 March 2020

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Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly

31 March 2020

1 reference

IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production

31 March 2020

1 reference

TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway

31 March 2020

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Functional assessment of the mutational effects of human IRAK4 and MyD88 genes

31 March 2020

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Assembly of oligomeric death domain complexes during Toll receptor signaling

31 March 2020

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Three-dimensional structure of a complex between the death domains of Pelle and Tube

31 March 2020

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Oncogenically active MYD88 mutations in human lymphoma

31 March 2020

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MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.

31 March 2020

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A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation

31 March 2020

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RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

31 March 2020

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Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

31 March 2020

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The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins

31 March 2020

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Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

31 March 2020

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Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling

31 March 2020

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Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

31 March 2020

1 reference

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

31 March 2020

1 reference

Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis

31 March 2020

1 reference

TLR3 deficiency in patients with herpes simplex encephalitis

31 March 2020

1 reference

Herpes simplex virus encephalitis in human UNC-93B deficiency

31 March 2020

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Toll-like receptor 3 promotes cross-priming to virus-infected cells.

31 March 2020

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Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.

31 March 2020

1 reference

Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells

31 March 2020

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A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses

31 March 2020

1 reference

A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4.

31 March 2020

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Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability

31 March 2020

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Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

31 March 2020

1 reference

MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor

31 March 2020

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Essential role of MD-2 in LPS responsiveness and TLR4 distribution.

31 March 2020

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The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane

31 March 2020

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31 March 2020

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The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes

31 March 2020

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Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

31 March 2020

1 reference

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

31 March 2020

1 reference

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

31 March 2020

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UNC93B1 mediates differential trafficking of endosomal TLRs

31 March 2020

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Functional rafts in cell membranes

31 March 2020

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Lipid rafts: elusive or illusive?

31 March 2020

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Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking

31 March 2020

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T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering

31 March 2020

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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.

31 March 2020

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Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling

31 March 2020

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Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.

31 March 2020

1 reference

A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction

31 March 2020

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Synergy between TLR2 and TLR4: a safety mechanism

31 March 2020

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Imaging intracellular fluorescent proteins at nanometer resolution

31 March 2020

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Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)

31 March 2020

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Ultra-high resolution imaging by fluorescence photoactivation localization microscopy

31 March 2020

1 reference

Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies

31 March 2020

1 reference

A phase I dose-finding study of the novel Toll-like receptor 8 agonist VTX-2337 in adult subjects with advanced solid tumors or lymphoma

31 March 2020

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Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures

31 March 2020

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The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI3713

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25060580%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

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