Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions (Q38258015)

1 September 2017

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title

Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions (English)

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1 September 2017

Satoshi Kubota

1

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PubMed ID

25294165

1 September 2017

Masaharu Takigawa

series ordinal

2

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PubMed ID

25294165

1 September 2017

language of work or name

English

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publication date

1 February 2015

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1 September 2017

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1 September 2017

128

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1 September 2017

3

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1 September 2017

181-196

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The role of CCN2 in cartilage and bone development

1 September 2017

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Roles for CCN2 in normal physiological processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

All in the CCN family: essential matricellular signaling modulators emerge from the bunker

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN family proteins and angiogenesis: from embryo to adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Proposal for a unified CCN nomenclature

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Adhesion-modulating/matricellular ECM protein families: a structural, functional and evolutionary appraisal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

The CCN family acting throughout the body: recent research developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

The CCN family: a new class of inflammation modulators?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Antiproliferative factor regulates connective tissue growth factor (CTGF/CCN2) expression in T24 bladder carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Thrombin-induced CCN2 expression in human lung fibroblasts requires the c-Src/JAK2/STAT3 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Nicotine-induced CCN2: from smoking to periodontal fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Novel chondrogenic and chondroprotective effects of the natural compound harmine

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Curcumin inhibits TGFβ1-induced CCN2 via Src, JNK, and Smad3 in gingiva.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Adenosine A(2A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Alpha-tocopherol induces expression of connective tissue growth factor and antagonizes tumor necrosis factor-alpha-mediated downregulation in human smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Simvastatin inhibits transforming growth factor-β1-induced expression of type I collagen, CTGF, and α-SMA in keloid fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Differential effects of simvastatin on mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Cysteine-rich protein 61 (CCN1) and connective tissue growth factor (CCN2) at the crosshairs of ocular neovascular and fibrovascular disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Oxidative stress modulates vascular smooth muscle cell phenotype via CTGF in thoracic aortic aneurysm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

The effects of low-intensity pulsed ultrasound exposure on gingival cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in ccn2 mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Downregulation of microRNA-19b contributes to angiotensin II-induced overexpression of connective tissue growth factor in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

The antifibrotic effects and mechanisms of microRNA-26a action in idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Connective tissue growth factor is a substrate of ADAM28.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN2: a master regulator of the genesis of bone and cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Role of LRP1 in transport of CCN2 protein in chondrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CTGF mediates Smad-dependent transforming growth factor β signaling to regulate mesenchymal cell proliferation during palate development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN2 as a novel molecule supporting energy metabolism of chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Differential roles of CCN family proteins during osteoblast differentiation: Involvement of Smad and MAPK signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Connective tissue growth factor (CTGF/CCN2) negatively regulates BMP-2 induced osteoblast differentiation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

The regenerative effects of CCN2 independent modules on chondrocytes in vitro and osteoarthritis models in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Connective tissue growth factor regulates interneuron survival and information processing in the olfactory bulb

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN2 modulates hair follicle cycling in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Dynamic analysis of the expression of the TGFbeta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

A perspective on anti-CCN2 therapy for chronic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

The matricellular protein CCN1 is essential for cardiac development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Thrombopoietic-mesenchymal interaction that may facilitate both endochondral ossification and platelet maturation via CCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CTGF induces monocyte chemoattractant protein-1 expression to enhance monocyte migration in human synovial fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Inhibition of connective tissue growth factor ameliorates disease in a murine model of rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

The C-terminal module IV of connective tissue growth factor is a novel immune modulator of the Th17 response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Connective tissue growth factor is a new ligand of epidermal growth factor receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

A physiological role for connective tissue growth factor in early wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN3 (NOV) is a negative regulator of CCN2 (CTGF) and a novel endogenous inhibitor of the fibrotic pathway in an in vitro model of renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

TNFα-induced apoptosis enabled by CCN1/CYR61: pathways of reactive oxygen species generation and cytochrome c release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin β1/focal adhesion kinase pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Expression and clinical significance of connective tissue growth factor in thyroid carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Reduced CTGF expression promotes cell growth, migration, and invasion in nasopharyngeal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Functional requirement of CCN2 for intramembranous bone formation in embryonic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN family member 2/connective tissue growth factor (CCN2/CTGF) has anti-aging effects that protect articular cartilage from age-related degenerative changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CTGF is a therapeutic target for metastatic melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CTGF increases drug resistance to paclitaxel by upregulating survivin expression in human osteosarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Reduction of urinary connective tissue growth factor by Losartan in type 1 patients with diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

BMP9 inhibits the bone metastasis of breast cancer cells by downregulating CCN2 (connective tissue growth factor, CTGF) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN2 is required for bleomycin-induced skin fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Requirement for active glycogen synthase kinase-3β in TGF-β1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Ets-1 is essential for connective tissue growth factor (CTGF/CCN2) induction by TGF-β1 in osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: implications for the pathogenesis of diabetic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140264

21 January 2018

Identifiers

DOI

10.1042/CS20140264

1 reference

1 September 2017

1 reference

PubMed ID

25294165