The Bcl-2 family: structures, interactions and targets for drug discovery (Q38268329)

1 September 2017

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title

The Bcl-2 family: structures, interactions and targets for drug discovery (English)

1 reference

1 September 2017

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25398535%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Mark G Hinds

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25398535%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Mark G Hinds

series ordinal

2

1 reference

1 September 2017

language of work or name

1 reference

1 February 2015

1 reference

1 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25398535%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25398535%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25398535%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

136-150

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25398535%20AND%20SRC:MED&resulttype=core&format=json

The BCL-2 protein family: opposing activities that mediate cell death

8 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

BCL2DB: database of BCL-2 family members and BH3-only proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Mechanisms of action of Bcl-2 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Structural biology of the Bcl-2 family and its mimicry by viral proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Living with death: the evolution of the mitochondrial pathway of apoptosis in animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Genetics of programmed cell death in C. elegans: past, present and future.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Evolution of the animal apoptosis network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Naturally occurring tumours in the basal metazoan Hydra

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Bcl-2 family proteins and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Viral control of mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Promoting apoptosis as a strategy for cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Solution structure of the BHRF1 protein from Epstein-Barr virus, a homolog of human Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Comparative genomics: the evolutionary history of the Bcl-2 family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Evolution of Bcl-2 homology motifs: homology versus homoplasy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The BCL-2 database, Act 2: moving beyond dualism to diversity and pleiotropy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Multipolar functions of BCL-2 proteins link energetics to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions: the next step forward or two steps back?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro- and anti-apoptotic Bcl-2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Molecular evolution of apoptotic pathways: cloning of key domains from sponges (Bcl-2 homology domains and death domains) and their phylogenetic relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Regulation of Bcl-2 family proteins by posttranslational modifications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Intrinsically disordered proteins in bcl-2 regulated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Inhibition of apoptosis by the African swine fever virus Bcl-2 homologue: role of the BH1 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

A survey of host range genes in poxvirus genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The genome of fowlpox virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The genome of canarypox virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Poxviruses and the evolution of host range and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Murine cytomegalovirus m38.5 protein inhibits Bax-mediated cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Regulation of apoptosis: uncovering the binding determinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Characterization of unique signature sequences in the divergent maternal protein Bcl2l10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The structural biology of BH3-only proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The structure of the C-terminal domain of the pro-apoptotic protein Bak and its interaction with model membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Interaction of the C-terminal domain of Bcl-2 family proteins with model membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Peptides derived from the transmembrane domain of Bcl-2 proteins as potential mitochondrial priming tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Molecular basis for membrane pore formation by Bax protein carboxyl terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Transmembrane pore formation by the carboxyl terminus of Bax protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

A surface groove essential for viral Bcl-2 function during chronic infection in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The E1B19K oncoprotein complexes with Beclin 1 to regulate autophagy in adenovirus-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

A179L, a new viral Bcl2 homolog targeting Beclin 1 autophagy related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Resilience of death: intrinsic disorder in proteins involved in the programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Tight regulation of unstructured proteins: from transcript synthesis to protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The carboxyl-terminal tail of Noxa protein regulates the stability of Noxa and Mcl-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Linear motifs: lost in (pre)translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Coupled folding and binding of the disordered protein PUMA does not require particular residual structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Solution structure of BID, an intracellular amplifier of apoptotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Mapping the interaction of pro-apoptotic tBID with pro-survival BCL-XL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Structural Insights of tBid, the Caspase-8-activated Bid, and Its BH3 Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

BAX activation is initiated at a novel interaction site

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Direct activation of full-length proapoptotic BAK

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Evaluation of the BH3-only protein Puma as a direct Bak activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

BH3 domains other than Bim and Bid can directly activate Bax/Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The vaccinia virus N1L protein is an intracellular homodimer that promotes virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Vaccinia virus protein F1L is a caspase-9 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Structural biology of the Bcl-2 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

BCL2L10 is a predictive factor for resistance to azacitidine in MDS and AML patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Programmed anuclear cell death delimits platelet life span.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Human viral oncogenesis: a cancer hallmarks analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Epstein-Barr virus and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The global health burden of infection-associated cancers in the year 2002

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

An Epstein-Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in burkitt lymphomagenesis: the Wp/BHRF1 link

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Crystallization and preliminary X-ray characterization of Epstein-Barr virus BHRF1 in complex with a benzoylurea peptidomimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Targeting -Herpesvirus 68 Bcl-2-mediated Down-regulation of Autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Mitochondrial involvement in cell death of non-mammalian eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Advances and pitfalls of protein structural alignment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

Unique structural features of a BCL-2 family protein CED-9 and biophysical characterization of CED-9/EGL-1 interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-014-1051-7

10.1007/S10495-014-1051-7

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25398535%20AND%20SRC:MED&resulttype=core&format=json

release_hdeeyfz5wjgz3b7l3b3dtbgaim

8 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hdeeyfz5wjgz3b7l3b3dtbgaim

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference