5-hydroxymethylcytosine: a potential therapeutic target in cancer (Q38272312)

1 September 2017

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title

5-hydroxymethylcytosine: a potential therapeutic target in cancer (English)

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1 September 2017

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431943%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Ian Morison

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431943%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1

Euan J Rodger

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9 June 2020

publication date

1 January 2014

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1 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431943%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

6

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9 June 2020

issue

5

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9 June 2020

page(s)

503-514

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DNA methylation: roles in mammalian development

9 June 2020

cites work

1 reference

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

21 January 2018

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Altered methylation patterns in cancer cell genomes: cause or consequence?

21 January 2018

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Active DNA demethylation: many roads lead to Rome.

21 January 2018

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The colorful history of active DNA demethylation.

21 January 2018

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Epigenetic reprogramming in mammalian development

21 January 2018

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

21 January 2018

1 reference

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.

21 January 2018

1 reference

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.

21 January 2018

1 reference

Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

21 January 2018

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High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells

21 January 2018

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Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

21 January 2018

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Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA

21 January 2018

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

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Potential functional roles of DNA demethylation intermediates

21 January 2018

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Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation

21 January 2018

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

21 January 2018

1 reference

TET enzymes, TDG and the dynamics of DNA demethylation.

21 January 2018

1 reference

Reversing DNA methylation: mechanisms, genomics, and biological functions

21 January 2018

1 reference

5-Hydroxymethylcytosine, the sixth base of the genome

21 January 2018

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Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

21 January 2018

1 reference

Quantification of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA from hepatocellular carcinoma tissues by capillary hydrophilic-interaction liquid chromatography/quadrupole TOF mass spectrometry.

21 January 2018

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5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations

21 January 2018

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Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma

21 January 2018

1 reference

Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

21 January 2018

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

21 January 2018

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Decreased 5-hydroxymethylcytosine levels are associated with TET2 mutation and unfavorable overall survival in myelodysplastic syndromes

21 January 2018

1 reference

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.

21 January 2018

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Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.

21 January 2018

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).

21 January 2018

1 reference

The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.

21 January 2018

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TET1 plays an essential oncogenic role in MLL-rearranged leukemia

21 January 2018

1 reference

High accuracy mutation detection in leukemia on a selected panel of cancer genes

21 January 2018

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TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases

21 January 2018

1 reference

Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas

21 January 2018

1 reference

Mutation in TET2 in myeloid cancers

21 January 2018

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Acquired mutations in TET2 are common in myelodysplastic syndromes

21 January 2018

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Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

21 January 2018

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Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

21 January 2018

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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

21 January 2018

1 reference

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

21 January 2018

1 reference

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity

21 January 2018

1 reference

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

21 January 2018

1 reference

Dnmt3a is essential for hematopoietic stem cell differentiation

21 January 2018

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DNMT3A Mutations in Acute Myeloid Leukemia

21 January 2018

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Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

21 January 2018

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Cytosine-5-methyltransferases add aldehydes to DNA.

21 January 2018

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The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases

21 January 2018

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Large conserved domains of low DNA methylation maintained by Dnmt3a

21 January 2018

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The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase

21 January 2018

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Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes.

21 January 2018

1 reference

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

1 reference

Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients

21 January 2018

1 reference

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

21 January 2018

1 reference

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

21 January 2018

1 reference

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

21 January 2018

1 reference

Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis

21 January 2018

1 reference

Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas

21 January 2018

1 reference

MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

21 January 2018

1 reference

5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging

21 January 2018

1 reference

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

21 January 2018

1 reference

Active repression of methylated genes by the chromosomal protein MBD1

21 January 2018

1 reference

Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells

21 January 2018

1 reference

Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells.

21 January 2018

1 reference

Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

21 January 2018

1 reference

The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

21 January 2018

1 reference

DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

21 January 2018

1 reference

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

21 January 2018

1 reference

The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

21 January 2018

1 reference

The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs

21 January 2018

1 reference

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

21 January 2018

1 reference

Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair.

21 January 2018

1 reference

Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition

21 January 2018

1 reference

Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency

21 January 2018

1 reference

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

21 January 2018

1 reference

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

21 January 2018

1 reference

Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution

21 January 2018

1 reference

Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming

21 January 2018

1 reference

Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA.

21 January 2018

1 reference

Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain.

21 January 2018

1 reference

Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver.

21 January 2018

1 reference

Integrated detection of both 5-mC and 5-hmC by high-throughput tag sequencing technology highlights methylation reprogramming of bivalent genes during cellular differentiation

21 January 2018

1 reference

Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.

21 January 2018

1 reference

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

21 January 2018

1 reference

Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia

21 January 2018

1 reference

Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma

21 January 2018

1 reference

Cancer epigenetics: from mechanism to therapy

21 January 2018

1 reference

MeCP2 and Rett syndrome: reversibility and potential avenues for therapy.

21 January 2018

1 reference

Selective DNA demethylation by fusion of TDG with a sequence-specific DNA-binding domain

21 January 2018

1 reference

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

21 January 2018

1 reference

Molecular biology. New tool for genome surgery

21 January 2018

1 reference

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

21 January 2018

1 reference

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

21 January 2018

1 reference

The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming

21 January 2018

1 reference

Antisense MBD2 gene therapy inhibits tumorigenesis

21 January 2018

1 reference

Deterministic direct reprogramming of somatic cells to pluripotency

21 January 2018

1 reference

Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells

21 January 2018

1 reference

Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer

21 January 2018

1 reference

Phase 1b-2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum-resistant or platinum-refractory epithelial ovarian cancer

21 January 2018

1 reference

MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation

21 January 2018

1 reference

The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation

21 January 2018

1 reference

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/EPI.14.39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431943%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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