Pontin is a critical regulator for AML1-ETO-induced leukemia (Q38310344)

2 September 2017

title

Pontin is a critical regulator for AML1-ETO-induced leukemia (English)

1 reference

2 September 2017

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24342949%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Lucas Waltzer

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24342949%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

O Breig

1

1 reference

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11 June 2020

S Bras

2

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11 June 2020

N Martinez Soria

3

1 reference

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11 June 2020

D Osman

4

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11 June 2020

O Heidenreich

5

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11 June 2020

publication date

17 December 2013

1 reference

2 September 2017

number of pages

9

1 reference

inferred from page(s)

published in

Leukemia

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11 June 2020

volume

28

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11 June 2020

issue

6

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11 June 2020

page(s)

1271-1279

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RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis

11 June 2020

cites work

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Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity.

21 January 2018

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Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

21 January 2018

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ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia

21 January 2018

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Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia

21 January 2018

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

21 January 2018

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AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

21 January 2018

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The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

21 January 2018

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C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice

21 January 2018

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The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation

21 January 2018

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Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.

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AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/β-catenin signaling pathway

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Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway

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Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias

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A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO

21 January 2018

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Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis

21 January 2018

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Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism

21 January 2018

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AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells

21 January 2018

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The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells

21 January 2018

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A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.

21 January 2018

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Subtle distinct regulations of late erythroid molecular events by PI3K/AKT-mediated activation of Spi-1/PU.1 oncogene autoregulation loop

21 January 2018

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Comparison of normalization methods for Illumina BeadChip HumanHT-12 v3.

21 January 2018

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Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity

21 January 2018

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GeneMANIA prediction server 2013 update

21 January 2018

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The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor

21 January 2018

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Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model

21 January 2018

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Pontin is essential for murine hematopoietic stem cell survival

21 January 2018

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TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis

21 January 2018

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Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin

21 January 2018

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Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex

21 January 2018

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Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

21 January 2018

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Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.

21 January 2018

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An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc

21 January 2018

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Myc roles in hematopoiesis and leukemia

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The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss

21 January 2018

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E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes

21 January 2018

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The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells.

21 January 2018

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Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly

21 January 2018

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Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.

21 January 2018

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The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis.

21 January 2018

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In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence

21 January 2018

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First identification of small-molecule inhibitors of Pontin by combining virtual screening and enzymatic assay

21 January 2018

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Reptin and pontin antagonistically regulate heart growth in zebrafish embryos.

21 January 2018

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Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer

21 January 2018

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Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics

21 January 2018

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

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An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

21 January 2018

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Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression.

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12 December 2020

Prediction and genetic demonstration of a role for activator E2Fs in Myc-induced tumors

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12 December 2020

TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling

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12 December 2020

Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

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12 December 2020

The multifaceted proteins Reptin and Pontin as major players in cancer

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12 December 2020

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

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12 December 2020

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

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12 December 2020