The role of regulatory variation in complex traits and disease (Q38364456)

2 September 2017

1 reference

title

The role of regulatory variation in complex traits and disease (English)

1 reference

2 September 2017

1 reference

Frank W Albert

1

0 references

author name string

Leonid Kruglyak

series ordinal

2

1 reference

2 September 2017

24 February 2015

1 reference

2 September 2017

Nature Reviews Genetics

1 reference

2 September 2017

16

1 reference

2 September 2017

197-212

1 reference

2 September 2017

4

1 reference

https://scigraph.springernature.com/pub.10.1038/nrg3891

2 September 2017

0 references

cites work

Genetical genomics: the added value from segregation.

1 reference

Genetic dissection of transcriptional regulation in budding yeast

31 March 2020

1 reference

Genetics of gene expression surveyed in maize, mouse and man

31 March 2020

1 reference

Genome-wide associations of gene expression variation in humans

31 March 2020

1 reference

Population genomics of human gene expression

31 March 2020

1 reference

Common regulatory variation impacts gene expression in a cell type-dependent manner

31 March 2020

1 reference

Genetic analysis of genome-wide variation in human gene expression

31 March 2020

1 reference

Genetics of gene expression and its effect on disease

31 March 2020

1 reference

Mapping determinants of human gene expression by regional and genome-wide association

31 March 2020

1 reference

Relative impact of nucleotide and copy number variation on gene expression phenotypes

31 March 2020

1 reference

Genetics of global gene expression

31 March 2020

1 reference

Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain

31 March 2020

1 reference

Genetic influences on brain gene expression in rats selected for tameness and aggression

31 March 2020

1 reference

Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages

31 March 2020

1 reference

Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.

31 March 2020

1 reference

Genetic analysis of complex traits in the emerging Collaborative Cross

31 March 2020

1 reference

Variations in DNA elucidate molecular networks that cause disease

31 March 2020

1 reference

An integrative genomics approach to infer causal associations between gene expression and disease

31 March 2020

1 reference

Genomic variation and its impact on gene expression in Drosophila melanogaster

31 March 2020

1 reference

Genetic dissection of the Drosophila melanogaster female head transcriptome reveals widespread allelic heterogeneity

31 March 2020

1 reference

Global eQTL mapping reveals the complex genetic architecture of transcript-level variation in Arabidopsis

31 March 2020

1 reference

Paternal dominance of trans-eQTL influences gene expression patterns in maize hybrids

31 March 2020

1 reference

System-wide molecular evidence for phenotypic buffering in Arabidopsis

31 March 2020

1 reference

Regulatory network construction in Arabidopsis by using genome-wide gene expression quantitative trait loci.

31 March 2020

1 reference

Expression variation in connected recombinant populations of Arabidopsis thaliana highlights distinct transcriptome architectures.

31 March 2020

1 reference

RNA sequencing reveals the complex regulatory network in the maize kernel

31 March 2020

1 reference

Genome-wide expression quantitative trait loci (eQTL) analysis in maize

31 March 2020

1 reference

Expression quantitative trait locus mapping across water availability environments reveals contrasting associations with genomic features in Arabidopsis.

31 March 2020

1 reference

Selection at linked sites shapes heritable phenotypic variation in C. elegans

31 March 2020

1 reference

Mapping determinants of gene expression plasticity by genetical genomics in C. elegans

31 March 2020

1 reference

Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors

31 March 2020

1 reference

Systematic localization of common disease-associated variation in regulatory DNA

31 March 2020

1 reference

The genetic basis of evolutionary change in gene expression levels

31 March 2020

1 reference

Inherited variation in gene expression

31 March 2020

1 reference

Determining causality and consequence of expression quantitative trait loci

31 March 2020

1 reference

Cellular genomics for complex traits

31 March 2020

1 reference

Global properties and functional complexity of human gene regulatory variation

31 March 2020

1 reference

Systems genetics approaches to understand complex traits

31 March 2020

1 reference

Local regulatory variation in Saccharomyces cerevisiae

31 March 2020

1 reference

Evolutionary changes in cis and trans gene regulation.

31 March 2020

1 reference

Transcriptome genetics using second generation sequencing in a Caucasian population

31 March 2020

1 reference

Understanding mechanisms underlying human gene expression variation with RNA sequencing

31 March 2020

1 reference

Cis-acting expression quantitative trait loci in mice

31 March 2020

1 reference

Allelic Variation in Human Gene Expression

31 March 2020

1 reference

Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals

31 March 2020

1 reference

The evolution of gene expression QTL in Saccharomyces cerevisiae

31 March 2020

1 reference

Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes

31 March 2020

1 reference

Gene-environment interaction in yeast gene expression

31 March 2020

1 reference

Natural genetic variation impacts expression levels of coding, non-coding, and antisense transcripts in fission yeast

31 March 2020

1 reference

Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

31 March 2020

1 reference

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'.

31 March 2020

1 reference

Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function

31 March 2020

1 reference

Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks

31 March 2020

1 reference

Genetic interactions between polymorphisms that affect gene expression in yeast

31 March 2020

1 reference

Comparative analysis of proteome and transcriptome variation in mouse

31 March 2020

1 reference

Genetic inheritance of gene expression in human cell lines

31 March 2020

1 reference

Heritability and tissue specificity of expression quantitative trait loci

31 March 2020

1 reference

Expression quantitative trait loci: replication, tissue- and sex-specificity in mice

31 March 2020

1 reference

Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals

31 March 2020

1 reference

Mapping cis- and trans-regulatory effects across multiple tissues in twins

31 March 2020

1 reference

Heritability and genomics of gene expression in peripheral blood

31 March 2020

1 reference

Common SNPs explain a large proportion of the heritability for human height

31 March 2020

1 reference

Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles

31 March 2020

1 reference

Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression

31 March 2020

1 reference

Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans

31 March 2020

1 reference

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

31 March 2020

1 reference

Systematic identification of trans eQTLs as putative drivers of known disease associations

31 March 2020

1 reference

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA

31 March 2020

1 reference

Cis and trans effects of human genomic variants on gene expression.

31 March 2020

1 reference

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

31 March 2020

1 reference

Common genetic variants modulate pathogen-sensing responses in human dendritic cells

31 March 2020

1 reference

Heritable individual-specific and allele-specific chromatin signatures in humans

31 March 2020

1 reference

Effects of sequence variation on differential allelic transcription factor occupancy and gene expression

31 March 2020

1 reference

Variation in transcription factor binding among humans

31 March 2020

1 reference

Effect of natural genetic variation on enhancer selection and function.

31 March 2020

1 reference

Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association

31 March 2020

1 reference

DNase I sensitivity QTLs are a major determinant of human expression variation

31 March 2020

1 reference

Genetic landscape of open chromatin in yeast.

31 March 2020

1 reference

DNA methylation contributes to natural human variation

31 March 2020

1 reference

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

31 March 2020

1 reference

Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels

31 March 2020

1 reference

Passive and active DNA methylation and the interplay with genetic variation in gene regulation

31 March 2020

1 reference

Contribution of genetic variation to transgenerational inheritance of DNA methylation

31 March 2020

1 reference

Noisy splicing drives mRNA isoform diversity in human cells.

31 March 2020

1 reference

Transcriptome and genome sequencing uncovers functional variation in humans

31 March 2020

1 reference

The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages.

31 March 2020

1 reference

Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits

31 March 2020

1 reference

Extent, causes, and consequences of small RNA expression variation in human adipose tissue

31 March 2020

1 reference

Genetic and epigenetic regulation of human lincRNA gene expression

31 March 2020

1 reference

Human disease-associated genetic variation impacts large intergenic non-coding RNA expression

31 March 2020

1 reference

The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels

31 March 2020

1 reference

Rare and common regulatory variation in population-scale sequenced human genomes

31 March 2020

1 reference

An integrated encyclopedia of DNA elements in the human genome

31 March 2020

1 reference

Identification of genetic variants that affect histone modifications in human cells

31 March 2020

1 reference

Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription

31 March 2020

1 reference

Extensive variation in chromatin states across humans

31 March 2020

1 reference

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

31 March 2020

1 reference

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

31 March 2020

1 reference

Differential contributions of rare and common, coding and noncoding Ret mutations to multifactorial Hirschsprung disease liability

31 March 2020

1 reference

A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter

31 March 2020

1 reference

The molecular mechanism of a cis-regulatory adaptation in yeast

31 March 2020

1 reference

Learning a prior on regulatory potential from eQTL data

31 March 2020

1 reference

Genetic architecture of ethanol-responsive transcriptome variation in Saccharomyces cerevisiae strains

31 March 2020

1 reference

Proteasomal degradation of human CYP1B1: effect of the Asn453Ser polymorphism on the post-translational regulation of CYP1B1 expression

31 March 2020

1 reference

Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories

31 March 2020

1 reference

A genome-wide association study identifies protein quantitative trait loci (pQTLs)

31 March 2020

1 reference

Identification of quantitative trait loci underlying proteome variation in human lymphoblastoid cells

31 March 2020

1 reference

Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels.

31 March 2020

1 reference

Genomic variation. Impact of regulatory variation from RNA to protein

31 March 2020

1 reference

A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis

31 March 2020

1 reference

Identification of cis-regulatory variation influencing protein abundance levels in human plasma.

31 March 2020

1 reference

Quantitative trait loci mapping of the mouse plasma proteome (pQTL)

31 March 2020

1 reference

Identification of genetic variants influencing the human plasma proteome

31 March 2020

1 reference

Variation and genetic control of protein abundance in humans

31 March 2020

1 reference

Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast

31 March 2020

1 reference

Genetic basis of proteome variation in yeast

31 March 2020

1 reference

Genetic variation shapes protein networks mainly through non-transcriptional mechanisms

31 March 2020

1 reference

Genetics of single-cell protein abundance variation in large yeast populations

31 March 2020

1 reference

Heritability and genetic basis of protein level variation in an outbred population

31 March 2020

1 reference

Global quantification of mammalian gene expression control

31 March 2020

1 reference

System wide analyses have underestimated protein abundances and the importance of transcription in mammals

31 March 2020

1 reference

Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling

31 March 2020

1 reference

Genetic influences on translation in yeast

31 March 2020

1 reference

Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans

31 March 2020

1 reference

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

31 March 2020

1 reference

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

31 March 2020

1 reference

Evolution of transcription factor binding in metazoans - mechanisms and functional implications

31 March 2020

1 reference

A molecular basis for classic blond hair color in Europeans

31 March 2020

1 reference

31 March 2020

1 reference

Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p

31 March 2020

1 reference

Nonlinear fitness consequences of variation in expression level of a eukaryotic gene

31 March 2020

1 reference

Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype

31 March 2020

1 reference

Single nucleotide variants in transcription factors associate more tightly with phenotype than with gene expression

31 March 2020

1 reference

Genetic interactions between transcription factors cause natural variation in yeast

31 March 2020

1 reference

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

31 March 2020

1 reference

The accessible chromatin landscape of the human genome

31 March 2020

1 reference

Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations

31 March 2020

1 reference

Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS

31 March 2020

1 reference

Biological insights from 108 schizophrenia-associated genetic loci

31 March 2020

1 reference

Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait

31 March 2020

1 reference

An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval

31 March 2020

1 reference

The Genotype-Tissue Expression (GTEx) project

31 March 2020

1 reference

Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression

31 March 2020

1 reference

Genetics and beyond--the transcriptome of human monocytes and disease susceptibility

31 March 2020

1 reference

Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs

31 March 2020

1 reference

Intersection of population variation and autoimmunity genetics in human T cell activation

31 March 2020

1 reference

Interindividual variation in human T regulatory cells

31 March 2020

1 reference

Impact of natural genetic variation on gene expression dynamics.

31 March 2020

1 reference

Expression quantitative trait loci are highly sensitive to cellular differentiation state

31 March 2020

1 reference

The promise of induced pluripotent stem cells in research and therapy

31 March 2020

1 reference

Genetic background drives transcriptional variation in human induced pluripotent stem cells

31 March 2020

1 reference

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

31 March 2020

1 reference

Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection

31 March 2020

1 reference

Genetics of gene expression in immunity to infection

31 March 2020

1 reference

Integrative genomic analysis of the human immune response to influenza vaccination

31 March 2020

1 reference

Linking disease associations with regulatory information in the human genome

31 March 2020

1 reference

Genetic and epigenetic fine mapping of causal autoimmune disease variants

31 March 2020

1 reference

All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs

31 March 2020

1 reference

Chromatin marks identify critical cell types for fine mapping complex trait variants

31 March 2020

1 reference

Joint analysis of functional genomic data and genome-wide association studies of 18 human traits

31 March 2020

1 reference

Integrating functional data to prioritize causal variants in statistical fine-mapping studies

31 March 2020

1 reference

A Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization.

31 March 2020

1 reference

GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation

31 March 2020

1 reference

Using functional annotation for the empirical determination of Bayes Factors for genome-wide association study analysis

31 March 2020

1 reference

Dissecting the regulatory architecture of gene expression QTLs

31 March 2020

1 reference

Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs

31 March 2020

1 reference

A statistical framework for joint eQTL analysis in multiple tissues

31 March 2020

1 reference

Robust prediction of expression differences among human individuals using only genotype information

31 March 2020

1 reference

Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method

31 March 2020

1 reference

Bayesian test for colocalisation between pairs of genetic association studies using summary statistics

31 March 2020

1 reference

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

31 March 2020

1 reference

Erratum: Corrigendum: Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

31 March 2020

1 reference

Mapping complex disease traits with global gene expression

31 March 2020

1 reference

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

31 March 2020

1 reference

Inactivation of the Fto gene protects from obesity

31 March 2020

1 reference

Obesity-associated variants within FTO form long-range functional connections with IRX3

31 March 2020

1 reference

Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions.

31 March 2020

1 reference

Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C).

31 March 2020

1 reference

Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements

31 March 2020

1 reference

Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C.

31 March 2020

1 reference

Capturing chromosome conformation

31 March 2020

1 reference

Comprehensive mapping of long-range interactions reveals folding principles of the human genome

31 March 2020

1 reference

Investigating human disease using stem cell models

31 March 2020

1 reference

Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq

31 March 2020

1 reference

Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types

31 March 2020

1 reference

The landscape of genetic complexity across 5,700 gene expression traits in yeast

31 March 2020

1 reference

RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans

31 March 2020

1 reference

Genetic interactions affecting human gene expression identified by variance association mapping

31 March 2020

1 reference

Another explanation for apparent epistasis

31 March 2020

1 reference

Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins

31 March 2020

1 reference

Data and theory point to mainly additive genetic variance for complex traits

31 March 2020

1 reference

Influence of gene interaction on complex trait variation with multilocus models

31 March 2020

1 reference

A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

31 March 2020

1 reference

Development and applications of CRISPR-Cas9 for genome engineering

31 March 2020

1 reference

CRISPR-Cas systems for editing, regulating and targeting genomes

31 March 2020

1 reference

Tackling the widespread and critical impact of batch effects in high-throughput data

31 March 2020

1 reference

On the design and analysis of gene expression studies in human populations

31 March 2020

1 reference

Capturing heterogeneity in gene expression studies by surrogate variable analysis

31 March 2020

1 reference

A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies

31 March 2020

1 reference

Genetic and nongenetic variation revealed for the principal components of human gene expression

31 March 2020

1 reference

Joint modelling of confounding factors and prominent genetic regulators provides increased accuracy in genetical genomics studies

31 March 2020

1 reference

Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses

31 March 2020

1 reference

Correction for hidden confounders in the genetic analysis of gene expression

31 March 2020

1 reference

Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots

31 March 2020

1 reference

HEFT: eQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors

31 March 2020

1 reference

Accounting for non-genetic factors by low-rank representation and sparse regression for eQTL mapping

31 March 2020

1 reference

Normalizing RNA-sequencing data by modeling hidden covariates with prior knowledge

31 March 2020

1 reference

Joint genetic analysis of gene expression data with inferred cellular phenotypes

31 March 2020

1 reference

Identifying the genetic determinants of transcription factor activity

31 March 2020

1 reference

Harnessing natural sequence variation to dissect posttranscriptional regulatory networks in yeast

31 March 2020

1 reference

The effects of genetic variation on gene expression dynamics during development

31 March 2020

1 reference

The Brisbane Systems Genetics Study: genetical genomics meets complex trait genetics

31 March 2020

1 reference

Global analysis of the impact of environmental perturbation on cis-regulation of gene expression

31 March 2020

1 reference

Genetic variability in the regulation of gene expression in ten regions of the human brain

31 March 2020

1 reference

Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants

31 March 2020

1 reference

Temporal dynamics and genetic control of transcription in the human prefrontal cortex

31 March 2020

1 reference

Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain

31 March 2020

1 reference

Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart

31 March 2020

1 reference

Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue

31 March 2020

1 reference

Mapping the genetic architecture of gene expression in human liver

31 March 2020

1 reference

Lung eQTLs to help reveal the molecular underpinnings of asthma

31 March 2020

1 reference

Putative cis-regulatory drivers in colorectal cancer.

31 March 2020

1 reference

Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types

31 March 2020

1 reference

Integrative eQTL-based analyses reveal the biology of breast cancer risk loci

31 March 2020

1 reference

Genetic Studies on Mutant Enzymes in Maize. III. Control of Gene Action in the Synthesis of Ph 7.5 Esterase

31 March 2020

1 reference

12 December 2020

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

1 reference

12 December 2020

Quantitative trait loci underlying gene product variation: a novel perspective for analyzing regulation of genome expression

1 reference

12 December 2020

Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling

1 reference

12 December 2020

Chitinase is required for cell separation during growth of Saccharomyces cerevisiae

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRG3891

1 reference

PubMed ID

25707927

Dimensions Publication ID

2 September 2017

0 references

1 reference

PubMed ID

25707927