Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies (Q38379348)

2 September 2017

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Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies (English)

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phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

2 September 2017

main subject

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author name string

Yongming Xi

series ordinal

1

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2 September 2017

Yan Chen

series ordinal

2

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2 September 2017

publication date

13 March 2015

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Journal of Cellular Biochemistry

2 September 2017

published in

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2 September 2017

volume

116

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2 September 2017

issue

9

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2 September 2017

page(s)

1837-1847

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Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

2 September 2017

cites work

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Subtle variations in Pten dose determine cancer susceptibility

21 January 2018

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Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line

21 January 2018

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Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

21 January 2018

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Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells.

21 January 2018

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Clinical presentation of PTEN mutations in childhood in the absence of family history of Cowden syndrome

21 January 2018

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Wnt pathway in osteosarcoma, from oncogenic to therapeutic

21 January 2018

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The phosphoinositide 3-kinase pathway

21 January 2018

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PTEN and the PI3-kinase pathway in cancer

21 January 2018

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Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.

21 January 2018

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PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells

21 January 2018

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PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling

21 January 2018

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The multiple layers of non-genetic regulation of PTEN tumour suppressor activity

21 January 2018

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Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

21 January 2018

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Bone-derived soluble factors and laminin-511 cooperate to promote migration, invasion and survival of bone-metastatic breast tumor cells

21 January 2018

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The multiple roles of PTEN in tumor suppression

21 January 2018

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In vitro and in vivo anti-tumor activity of miR-221/222 inhibitors in multiple myeloma

21 January 2018

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Therapeutic targeting of cancers with loss of PTEN function

21 January 2018

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RANKL signaling in bone physiology and cancer

21 January 2018

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 January 2018

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PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.

21 January 2018

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Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors

21 January 2018

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Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.

21 January 2018

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miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

21 January 2018

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PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control

21 January 2018

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BYL719, a new α-specific PI3K inhibitor: single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma

21 January 2018

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PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer.

21 January 2018

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Testing of the Akt/PKB inhibitor MK-2206 by the Pediatric Preclinical Testing Program.

21 January 2018

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Rapamycin increases neuroblastoma xenograft and host stromal derived osteoprotegerin inhibiting osteolytic bone disease in a bone metastasis model

21 January 2018

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A secreted PTEN phosphatase that enters cells to alter signaling and survival

21 January 2018

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Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment

21 January 2018

1 reference

ERBB receptors and cancer: the complexity of targeted inhibitors

21 January 2018

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Bringing target-matched PI3King from the bench to the clinic

21 January 2018

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High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor

21 January 2018

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Prostate carcinoma skeletal metastases: cross-talk between tumor and bone.

21 January 2018

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Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP

21 January 2018

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Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy.

21 January 2018

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Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth

21 January 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

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Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review

21 January 2018

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PTEN mutation is rare in chondrosarcoma.

21 January 2018

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Celecoxib, a cyclooxygenase-2 inhibitor, induces apoptosis in human osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt

21 January 2018

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Osteoblasts in prostate cancer metastasis to bone

21 January 2018

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Everolimus enhances the cytotoxicity of bendamustine in multiple myeloma cells through a network of pro-apoptotic and cell-cycle-progression regulatory proteins

21 January 2018

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 January 2018

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High-resolution genome-wide copy-number analyses identify localized copy-number alterations in Ewing sarcoma.

21 January 2018

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The methylation of a panel of genes differentiates low-grade from high-grade gliomas.

21 January 2018

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Is PTEN loss associated with clinical outcome measures in human prostate cancer?

21 January 2018

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Interaction of ligand-receptor system between stromal-cell-derived factor-1 and CXC chemokine receptor 4 in human prostate cancer: a possible predictor of metastasis

21 January 2018

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Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade

21 January 2018

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PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome

21 January 2018

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Metastasis to bone: causes, consequences and therapeutic opportunities

21 January 2018

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Modulation of the osteosarcoma expression phenotype by microRNAs

21 January 2018

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Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes

21 January 2018

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Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome.

21 January 2018

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PTEN deficiency mediates a reciprocal response to IGFI and mTOR inhibition

21 January 2018

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Methylation analysis of the phosphates and tensin homologue on chromosome 10 gene (PTEN) in multiple myeloma

21 January 2018

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Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

21 January 2018

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The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells

21 January 2018

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PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.

21 January 2018

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Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer.

21 January 2018

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MicroRNA-128 promotes proliferation in osteosarcoma cells by downregulating PTEN.

21 January 2018

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MLN0128, an ATP-competitive mTOR kinase inhibitor with potent in vitro and in vivo antitumor activity, as potential therapy for bone and soft-tissue sarcoma

21 January 2018

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

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PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility

21 January 2018

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Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo

21 January 2018

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PTEN gene and integrin signaling in cancer

21 January 2018

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PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

21 January 2018

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PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy.

21 January 2018

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Effect of wild type PTEN gene on proliferation and invasion of multiple myeloma

21 January 2018

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The role of PTEN in prostate cancer cell tropism to the bone micro-environment

21 January 2018

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Celecoxib Inhibits β-Catenin-Dependent Survival of the Human Osteosarcoma MG-63 Cell Line

21 January 2018

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MicroRNA-21 controls hTERT via PTEN in human colorectal cancer cell proliferation

21 January 2018

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Perifosine induces cell apoptosis in human osteosarcoma cells: new implication for osteosarcoma therapy?

21 January 2018

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Everolimus and zoledronic acid--a potential synergistic treatment for lung adenocarcinoma bone metastasis

21 January 2018

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MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.25159

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2 September 2017

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