The WNT system: background and its role in bone (Q38407357)

2 September 2017

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title

The WNT system: background and its role in bone (English)

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2 September 2017

C Ohlsson

2

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Ulf H Lerner

series ordinal

1

object named as

U H Lerner

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PubMed ID

25845559

2 September 2017

language of work or name

English

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publication date

1 June 2015

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Journal of Internal Medicine

2 September 2017

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2 September 2017

277

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2 September 2017

6

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2 September 2017

630-649

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Effect of the Wingless (wg1) mutation on wing and haltere development in Drosophila melanogaster

2 September 2017

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Mutations affecting segment number and polarity in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1111%2FJOIM.12368

SOME POSSIBLE EFFECTS OF NURSING ON THE MAMMARY GLAND TUMOR INCIDENCE IN MICE.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJOIM.12368

Purification of the mouse mammary tumour virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Wnt/β-catenin signaling and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Wnt/beta-catenin signaling: components, mechanisms, and diseases

21 January 2018

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https://api.crossref.org/works/10.1111%2FJOIM.12368

Towards an integrated view of Wnt signaling in development

21 January 2018

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https://api.crossref.org/works/10.1111%2FJOIM.12368

Selective activation mechanisms of Wnt signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1111%2FJOIM.12368

WNT signaling in bone homeostasis and disease: from human mutations to treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Planar cell polarity signaling in the Drosophila eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Wnt and calcium signaling: beta-catenin-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Romosozumab in postmenopausal women with low bone mineral density.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

The role of Dickkopf-1 in bone development, homeostasis, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Human autosomal recessive osteopetrosis maps to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

High bone density due to a mutation in LDL-receptor-related protein 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

LRP6 mutation in a family with early coronary disease and metabolic risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Heterozygous mutations in the LDL receptor-related protein 5 (LRP5) gene are associated with primary osteoporosis in children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Mutations in WNT1 cause different forms of bone fragility

21 January 2018

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https://api.crossref.org/works/10.1111%2FJOIM.12368

Rare variations in WNT3A and DKK1 may predispose carriers to primary osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Variation in the Kozak sequence of WNT16 results in an increased translation and is associated with osteoporosis related parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Update on Wnt signaling in bone cell biology and bone disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

High bone mass in mice expressing a mutant LRP5 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Lrp5 functions in bone to regulate bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Wntless functions in mature osteoblasts to regulate bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

WNT7B promotes bone formation in part through mTORC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Regulation of osteoblastogenesis and bone mass by Wnt10b

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

21 January 2018

The amazing osteocyte

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

The osteocyte: an endocrine cell ... and more

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Genetic evidence that SOST inhibits WNT signaling in the limb

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Relation of age, gender, and bone mass to circulating sclerostin levels in women and men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Serum sclerostin levels in men with idiopathic osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Essential role of beta-catenin in postnatal bone acquisition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Denosumab and bisphosphonates: different mechanisms of action and effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Osteoporosis in 2011: Osteoporosis therapy--dawn of the post-bisphosphonate era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Sclerostin antibody stimulates bone regeneration after experimental periodontitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Efficacy of a sclerostin antibody compared to a low dose of PTH on metaphyseal bone healing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Sclerostin antibody increases bone volume and enhances implant fixation in a rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12368

21 January 2018

Identifiers

DOI

10.1111/JOIM.12368

1 reference

2 September 2017

1 reference

PubMed ID

25845559