Review article: recent advances in pharmacogenetics and pharmacokinetics for safe and effective thiopurine therapy in inflammatory bowel disease. (Q38417177)

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scientific article published on 14 February 2016

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English	Review article: recent advances in pharmacogenetics and pharmacokinetics for safe and effective thiopurine therapy in inflammatory bowel disease.	scientific article published on 14 February 2016

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scholarly article

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Europe PubMed Central

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8 March 2020

Review article: recent advances in pharmacogenetics and pharmacokinetics for safe and effective thiopurine therapy in inflammatory bowel disease (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26876431%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

inflammatory bowel diseases

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pharmacokinetics

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based on heuristic

inferred from title

Edward V Loftus

2

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Europe PubMed Central

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8 March 2020

author name string

W Moon

1

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Europe PubMed Central

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8 March 2020

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publication date

14 February 2016

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Europe PubMed Central

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8 March 2020

Alimentary Pharmacology & Therapeutics

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Europe PubMed Central

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8 March 2020

43

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8 March 2020

8

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Europe PubMed Central

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8 March 2020

863-883

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26876431%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Randomised controlled trial of azathioprine withdrawal in ulcerative colitis

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery

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21 January 2018

Biological therapy in the management of recent-onset Crohn's disease: why, when and how?

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21 January 2018

Can we alter the natural history of Crohn disease in children?

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21 January 2018

Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease

1 reference

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21 January 2018

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Safety of thiopurine therapy in inflammatory bowel disease: long-term follow-up study of 3931 patients.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine therapy in inflammatory bowel disease patients: analyses of two 8-year intercept cohorts

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Meta-analysis: the efficacy of azathioprine and mercaptopurine in ulcerative colitis

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Pharmacogenomics and IBD: TPMT and thiopurines

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Individualized therapy with azathioprine or 6-mercaptopurine by monitoring thiopurine methyl-transferase (TPMT) activity

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Review article: thiopurines in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Clinical pharmacology and pharmacogenetics of thiopurines

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

TPMT in the treatment of Crohn's disease with azathioprine

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Selective inhibition of inflammatory gene expression in activated T lymphocytes: a mechanism of immune suppression by thiopurines

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Some cases demonstrating the clinical usefulness of therapeutic drug monitoring in thiopurine-treated inflammatory bowel disease patients

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Characterisation of novel defective thiopurine S-methyltransferase allelic variants.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2 - *24).

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

TPMT*26 (208F-->L), a novel mutation detected in a Chinese

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Detection of a novel single nucleotide polymorphism of the human thiopurine s-methyltransferase gene in a Chinese individual

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Assessment of thiopurine S-methyltransferase activity in patients prescribed thiopurines: a systematic review

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Mistaken identity: misclassification of TPMT phenotype following blood transfusion

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

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21 January 2018

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity

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21 January 2018

Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis

1 reference

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21 January 2018

Detection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysis

1 reference

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21 January 2018

Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences

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MTHFR and TYMS genotypes influence TPMT activity and its differential modulation in males and females.

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Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation

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Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia

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21 January 2018

Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects

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21 January 2018

Whole-blood thiopurine S-methyltransferase activity with genotype concordance: a new, simplified phenotyping assay.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Guidelines for prescribing azathioprine in dermatology.

1 reference

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Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain

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Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription.

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21 January 2018

Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

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Clinical implementation of pharmacogenomics: overcoming genetic exceptionalism

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Testing for thiopurine methyltransferase status for safe and effective thiopurine administration: a systematic review of clinical guidance documents

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Toward a personalized medicine approach to the management of inflammatory bowel disease

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Two cases of thiopurine methyltransferase (TPMT) deficiency--a lucky save and a near miss with azathioprine

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21 January 2018

Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression

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https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Relevance of thiopurine methyltransferase activity in inflammatory bowel disease patients maintained on low-dose azathioprine

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21 January 2018

Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy

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21 January 2018

Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease

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21 January 2018

Ethnic differences in pharmacogenetically relevant genes

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21 January 2018

Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications?

1 reference

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21 January 2018

Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come

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21 January 2018

Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia

1 reference

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21 January 2018

Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine

1 reference

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21 January 2018

A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine

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21 January 2018

American Gastroenterological Association Institute medical position statement on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease

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21 January 2018

Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Timing of myelosuppression during thiopurine therapy for inflammatory bowel disease: implications for monitoring recommendations

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Initiating azathioprine for Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

6-mercaptopurine metabolite levels in children with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Optimizing therapy with 6-mercaptopurine and azathioprine: to measure or not to measure?

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial

1 reference

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21 January 2018

6-thioguanine can cause serious liver injury in inflammatory bowel disease patients

1 reference

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21 January 2018

Veno-occlusive disease in patients receiving thiopurines during maintenance therapy for childhood acute lymphoblastic leukaemia

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine maintenance therapy for ulcerative colitis: the clinical significance of monitoring 6-thioguanine nucleotide

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Monitoring of thiopurine metabolites in patients with inflammatory bowel disease-what is actually measured?

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine methyltransferase and thiopurine metabolite testing in patients with inflammatory bowel disease who are taking thiopurine drugs.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

5-aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine metabolite ratios for monitoring therapy in pediatric Crohn disease.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Hepatotoxicity of 6-mercaptopurine (6-MP) and Azathioprine (AZA) in adult IBD patients

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Pharmacogenetics of thiopurines in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

A comparison of the specificities of xanthine oxidase and aldehyde oxidase.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Human liver xanthine oxidase: Nature and extent of individual variation

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Functional characterization of human xanthine oxidase allelic variants

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Molybdenum cofactor biosynthesis and deficiency

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Molybdenum cofactor deficiency: clinical features in a Turkish patient

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Structure and function of xanthine oxidoreductase: where are we now?

1 reference

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21 January 2018

A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout

1 reference

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21 January 2018

Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Observations on the use of allopurinol in combination with azathioprine or mercaptopurine

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Mechanism of allopurinol induced TPMT inhibition

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Safety and effectiveness of long-term allopurinol-thiopurine maintenance treatment in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Long term efficacy and safety of allopurinol and azathioprine or 6-mercaptopurine in patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Use of allopurinol with low-dose 6-mercaptopurine in inflammatory bowel disease to achieve optimal active metabolite levels: a review of four cases and the literature

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Safety of urate-lowering therapies: managing the risks to gain the benefits

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

A pharmacogenetic basis for the safe and effective use of azathioprine and other thiopurine drugs in dermatologic patients

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Allopurinol enhanced thiopurine treatment for inflammatory bowel disease: safety considerations and guidelines for use.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Allopurinol use in pregnancy in three women with inflammatory bowel disease: safety and outcomes: a case series.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Successful Pregnancies with Thiopurine-Allopurinol Co-Therapy for Inflammatory Bowel Disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

In vitro oxidative metabolism of 6-mercaptopurine in human liver: insights into the role of the molybdoflavoenzymes aldehyde oxidase, xanthine oxidase, and xanthine dehydrogenase

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

House cleaning, a part of good housekeeping

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Human inosine triphosphatase: Catalytic properties and population studies

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency in the Japanese population

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Measurement of erythrocyte inosine triphosphate pyrophosphohydrolase (ITPA) activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasian population

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Distribution of ITPA P32T alleles in multiple world populations

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Pharmacogenetic analysis of pediatric patients with acute lymphoblastic leukemia: a possible association between survival rate and ITPA polymorphism

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Association between adverse effects under azathioprine therapy and inosine triphosphate pyrophosphatase activity in patients with chronic inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

The purine path to chemotherapy

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Enzymatic thiolysis of azathioprine in vitro

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Association of antioxidant enzyme gene polymorphisms and glutathione status with severe acute pancreatitis

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Pharmacogenetics of azathioprine in inflammatory bowel disease: a role for glutathione-S-transferase?

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

The role of glutathione-S-transferase in anti-cancer drug resistance

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease.

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Deletion of glutathione-s-transferase m1 reduces azathioprine metabolite concentrations in young patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

A specific enzyme defect in gout associated with overproduction of uric acid

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Hypoxanthine-guanine phosphoribosyltransferase deficiency. The molecular basis of the clinical syndromes

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Allelotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine methyltransferase gene polymorphisms in Chinese patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Thiopurine methyltransferase alleles in British and Ghanaian populations

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FAPT.13559

21 January 2018

Identifiers

10.1111/APT.13559

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26876431%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26876431%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

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