Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways (Q38423395)

3 September 2017

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title

Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways (English)

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3 September 2017

1

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3 September 2017

Clare E Bryant

2

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3 September 2017

1 May 2015

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3 September 2017

Immunological Reviews

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3 September 2017

265

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3 September 2017

1

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3 September 2017

181-193

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Caspases and immunity in a deadly grip

3 September 2017

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Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

21 January 2018

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

21 January 2018

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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

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From procaspase-8 to caspase-8: revisiting structural functions of caspase-8.

21 January 2018

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Necroptosis: the release of damage-associated molecular patterns and its physiological relevance

21 January 2018

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Non-apoptotic functions of cell death effectors in inflammation and innate immunity

21 January 2018

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More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

21 January 2018

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Molecular mechanisms of necroptosis: an ordered cellular explosion

21 January 2018

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The 'complexities' of life and death: death receptor signalling platforms

21 January 2018

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Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.

21 January 2018

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Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation

21 January 2018

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21 January 2018

The flip side of FLIP

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Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

21 January 2018

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CD95 stimulation results in the formation of a novel death effector domain protein-containing complex

21 January 2018

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Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis

21 January 2018

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

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Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

21 January 2018

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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

21 January 2018

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The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

21 January 2018

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Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

21 January 2018

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The inflammasome NLRs in immunity, inflammation, and associated diseases

21 January 2018

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Mechanisms and functions of inflammasomes

21 January 2018

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Mechanism of NLRP3 inflammasome activation

21 January 2018

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21 January 2018

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Sensing and reacting to microbes through the inflammasomes

21 January 2018

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

21 January 2018

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The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

21 January 2018

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Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages

21 January 2018

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The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

21 January 2018

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ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells

21 January 2018

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ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis

21 January 2018

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An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.

21 January 2018

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Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

21 January 2018

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Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

21 January 2018

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Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

21 January 2018

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Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

21 January 2018

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Structural study of the RIPoptosome core reveals a helical assembly for kinase recruitment

21 January 2018

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The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

21 January 2018

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The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

21 January 2018

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The Fas-FADD death domain complex structure unravels signalling by receptor clustering

21 January 2018

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Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication

21 January 2018

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Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells

21 January 2018

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Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.

21 January 2018

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Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.

21 January 2018

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

21 January 2018

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Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing

21 January 2018

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Immunological and inflammatory functions of the interleukin-1 family

21 January 2018

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Treating inflammation by blocking interleukin-1 in humans

21 January 2018

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

21 January 2018

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Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.

21 January 2018

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Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner

21 January 2018

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Release of interleukin-1α or interleukin-1β depends on mechanism of cell death

21 January 2018

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Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells

21 January 2018

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Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

21 January 2018

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Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans

21 January 2018

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Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production

21 January 2018

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Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

21 January 2018

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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

21 January 2018

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FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.

21 January 2018

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Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation.

21 January 2018

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AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages.

21 January 2018

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AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.

21 January 2018

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Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.

21 January 2018

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Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.

21 January 2018

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Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis

21 January 2018

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Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

21 January 2018

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Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

21 January 2018

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Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

21 January 2018

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DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration

21 January 2018

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Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma

21 January 2018

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Caspase signalling controls microglia activation and neurotoxicity.

21 January 2018

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Near death experiences: poxvirus regulation of apoptotic death

21 January 2018

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Prevention of apoptosis by a baculovirus gene during infection of insect cells

21 January 2018

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Inhibition of apoptosis by the gamma-herpesviruses

21 January 2018

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Caspase inhibitors: viral, cellular and chemical

21 January 2018

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Virus inhibition of RIP3-dependent necrosis

21 January 2018

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RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein

21 January 2018

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Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA

21 January 2018

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Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)

21 January 2018

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TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

21 January 2018

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FLICE Induced Apoptosis in a Cell-free System

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12284

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3 September 2017

1 reference

PubMed ID

25879293