Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era. (Q38431759)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25896087%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

review article

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title

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25896087%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

6 March 2020

main subject

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author

Stephen A Goutman

4

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6 March 2020

Eva Feldman

5

1 reference

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6 March 2020

Claudia Figueroa-Romero

2

object named as

Claudia Figueroa-Romero

1 reference

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6 March 2020

3

Stacey A Sakowski

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6 March 2020

Ximena Paez-Colasante

1

object named as

Ximena Paez-Colasante

1 reference

6 March 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25896087%20AND%20SRC:MED&resulttype=core&format=json

language of work or name

English

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publication date

21 April 2015

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25896087%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

published in

Nature Reviews Neurology

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6 March 2020

volume

11

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6 March 2020

issue

5

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6 March 2020

page(s)

266-279

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The changing scene of amyotrophic lateral sclerosis

6 March 2020

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C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

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Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

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31 March 2020

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Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).

31 March 2020

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A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

31 March 2020

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Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

31 March 2020

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31 March 2020

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31 March 2020

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Hypermethylation of the CpG island near the G4C2 repeat in ALS with a C9orf72 expansion

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31 March 2020

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31 March 2020

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31 March 2020

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Two novel mutations in conserved codons indicate that CHCHD10 is a gene associated with motor neuron disease

31 March 2020

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

31 March 2020

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Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis

31 March 2020

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Dementia and cognitive impairment in amyotrophic lateral sclerosis: a review

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Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

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Exome sequencing reveals VCP mutations as a cause of familial ALS

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An estimate of amyotrophic lateral sclerosis heritability using twin data.

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Abnormal distribution of lead in amyotrophic lateral sclerosis--reestimation of lead in the cerebrospinal fluid

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Lead concentration in skeletal muscle in amyotrophic lateral sclerosis patients and control subjects

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Increased plasma levels of lead in patients with amyotrophic lateral sclerosis compared with control subjects as determined by flameless atomic absorption spectrophotometry

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Association between blood lead and the risk of amyotrophic lateral sclerosis

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A meta-analysis of observational studies of the association between chronic occupational exposure to lead and amyotrophic lateral sclerosis

31 March 2020

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The Association of Exposure to Lead, Mercury, and Selenium and the Development of Amyotrophic Lateral Sclerosis and the Epigenetic Implications

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Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam

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Chronic low-Ca/Mg high-Al diet induces neuronal loss

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Epidemiologic study of amyotrophic lateral sclerosis in Sardinia, Italy

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Environmental risk factors and amyotrophic lateral sclerosis (ALS): a case-control study of ALS in Michigan

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Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease

31 March 2020

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5'-Aza-dC sensitizes paraquat toxic effects on PC12 cell

31 March 2020

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Population-based case-control study of amyotrophic lateral sclerosis in western Washington State. I. Cigarette smoking and alcohol consumption

31 March 2020

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Smoking and risk of amyotrophic lateral sclerosis: a pooled analysis of 5 prospective cohorts

31 March 2020

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Smoking, Alcohol Consumption, and the Risk of Amyotrophic Lateral Sclerosis: A Population-based Study

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Association of smoking with amyotrophic lateral sclerosis risk and survival in men and women: a prospective study

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Occurrence of amyotrophic lateral sclerosis among Gulf War veterans

31 March 2020

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Perceptions of epigenetics

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Epigenetic mechanisms governing the process of neurodegeneration

31 March 2020

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Glial epigenetics in neuroinflammation and neurodegeneration

31 March 2020

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Epigenetic regulation of motor neuron cell death through DNA methylation

31 March 2020

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Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated

31 March 2020

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Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

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A comparative analysis of DNA methylation across human embryonic stem cell lines

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Active DNA demethylation in post-mitotic neurons: a reason for optimism

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Dynamic changes in the human methylome during differentiation

31 March 2020

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Epigenetic regulation of neural gene expression and neuronal function

31 March 2020

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Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset

31 March 2020

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A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis.

31 March 2020

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Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Hypermethylation of the CpG-island near the C9orf72 G₄C₂-repeat expansion in FTLD patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Histone deacetylases and their role in motor neuron degeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

The diverse functions of histone lysine methylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Genetic analysis of SS18L1 in French amyotrophic lateral sclerosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

AMPA receptor-mediated neuronal death in sporadic ALS.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Glutamate receptors: RNA editing and death of motor neurons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

The molecular link between inefficient GluA2 Q/R site-RNA editing and TDP-43 pathology in motor neurons of sporadic amyotrophic lateral sclerosis patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Identification of novel genes coding for small expressed RNAs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

MicroRNAs: genomics, biogenesis, mechanism, and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

An extensive class of small RNAs in Caenorhabditis elegans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Widespread changes in protein synthesis induced by microRNAs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Principles and effects of microRNA-mediated post-transcriptional gene regulation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Dysregulated microRNAs in neurodegenerative disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

MicroRNA-124 regulates neuronal differentiation of mesenchymal stem cells by targeting Sp1 mRNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Identification of tissue-specific microRNAs from mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

miR-9: a versatile regulator of neurogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

MicroRNA genes are transcribed by RNA polymerase II

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Many roads to maturity: microRNA biogenesis pathways and their regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

MicroRNA maturation: stepwise processing and subcellular localization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

The nuclear RNase III Drosha initiates microRNA processing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Intronic microRNA precursors that bypass Drosha processing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

miRNA malfunction causes spinal motor neuron disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

MicroRNA turnover: when, how, and why.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Altered microRNA expression profile in Amyotrophic Lateral Sclerosis: a role in the regulation of NFL mRNA levels

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Crosstalk among Epigenetic Pathways Regulates Neurogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Neuronal dark matter: the emerging role of microRNAs in neurodegeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

A novel nuclear miRNA mediated modulation of a non-coding antisense RNA and its cognate sense coding mRNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: potential role in reinnervation ability and disease progression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

An ALS-associated mutation in the FUS 3'-UTR disrupts a microRNA-FUS regulatory circuitry

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

The emerging roles of microRNAs in the pathogenesis of frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) spectrum disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Nuclear factor TDP-43 can affect selected microRNA levels

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

The Promise of MicroRNA Replacement Therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Combined riluzole and sodium phenylbutyrate therapy in transgenic amyotrophic lateral sclerosis mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Phase 2 study of sodium phenylbutyrate in ALS.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Epigenetics of Alzheimer's disease and frontotemporal dementia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

The role of miRNA in motor neuron disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Preliminary Notes on the Development of the Wings in Normal and Mutant Strains of Drosophila

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

An operational definition of epigenetics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Phenotypic differences in genetically identical organisms: the epigenetic perspective.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.57

Epigenetic therapy: use of agents targeting deacetylation and methylation in cancer management

31 March 2020

1 reference

12 December 2020

Prognosis and epidemiology of amyotrophic lateral sclerosis: Analysis of a clinic population, 1997-2011.

1 reference

12 December 2020

Matters of life and death: the role of chromatin remodeling proteins in retinal neuron survival

1 reference

12 December 2020

Lead content of neuromuscular tissue in amyotrophic lateral sclerosis: case report and other considerations

1 reference

12 December 2020

FUS mutations in frontotemporal lobar degeneration with amyotrophic lateral sclerosis

1 reference

12 December 2020