Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target (Q38450536)

3 September 2017

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title

Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target (English)

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3 September 2017

main subject

hepatocellular carcinoma

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Yuting Wu

1

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3 September 2017

Xiaoming Meng

series ordinal

2

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3 September 2017

Cheng Huang

series ordinal

3

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3 September 2017

Jun Li

series ordinal

4

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3 September 2017

publication date

1 May 2015

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3 September 2017

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3 September 2017

volume

36

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3 September 2017

issue

6

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3 September 2017

page(s)

4063-4074

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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

3 September 2017

cites work

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12 December 2020

Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1

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12 December 2020

Annual report on status of cancer in China, 2010.

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12 December 2020

P53 is a tumor suppressor gene

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12 December 2020

Resveratrol alleviates alcoholic fatty liver in mice

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12 December 2020

Mechanism of human SIRT1 activation by resveratrol

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12 December 2020

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis.

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12 December 2020

Hippo/YAP, β-catenin, and the cancer cell: a "ménage à trois" in hepatoblastoma

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12 December 2020

SIRT1 deacetylates and positively regulates the nuclear receptor LXR

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12 December 2020

Structural basis for sirtuin activity and inhibition

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12 December 2020

Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT.

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12 December 2020

Pathways and targets in hepatocellular carcinoma

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12 December 2020

The metabolic sensors FXRα, PGC-1α, and SIRT1 cooperatively regulate hepatitis B virus transcription.

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12 December 2020

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

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12 December 2020

Resveratrol suppresses hepatoma cell invasion independently of its anti-proliferative action

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12 December 2020

Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis

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12 December 2020

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

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12 December 2020

Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells

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12 December 2020

Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma

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12 December 2020

The role of the liver in metabolic homeostasis: Implications for inborn errors of metabolism

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12 December 2020

Roles of SIRT1 in leukemogenesis

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12 December 2020

Sirtuins as regulators of metabolism and healthspan

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12 December 2020

Substrate-specific activation of sirtuins by resveratrol

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12 December 2020

Prognostic role of SIRT1 in hepatocellular carcinoma

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12 December 2020

SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas

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12 December 2020

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

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12 December 2020

Telomere length, stem cells and aging

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12 December 2020

Liver cancer: descriptive epidemiology and risk factors other than HBV and HCV infection

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12 December 2020

SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration

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12 December 2020

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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12 December 2020

Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells

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12 December 2020

The effect of alcohol on Sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC)

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12 December 2020

SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma

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12 December 2020

High telomerase activity and long telomeres in advanced hepatocellular carcinomas with poor prognosis.

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12 December 2020

Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

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12 December 2020

Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver

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12 December 2020

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

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12 December 2020

SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53.

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12 December 2020

Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo

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12 December 2020

Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.

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12 December 2020

c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver.

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12 December 2020

Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

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12 December 2020

Shelterin: the protein complex that shapes and safeguards human telomeres

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12 December 2020

SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.

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12 December 2020

MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma

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12 December 2020

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

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12 December 2020

Sorafenib in advanced hepatocellular carcinoma

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12 December 2020

Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.

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12 December 2020

Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases

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12 December 2020

Phase 2 open-label study of single-agent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: presence of lung metastasis predicts poor response.

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12 December 2020

Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae

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12 December 2020

Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice.

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12 December 2020

Quit your YAPing: a new target for cancer therapy

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12 December 2020

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

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12 December 2020

Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism

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12 December 2020

Crystal structure of a SIR2 homolog-NAD complex

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12 December 2020

Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice.

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12 December 2020

Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice

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12 December 2020

SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism

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12 December 2020

Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion

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12 December 2020

Oncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor model

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12 December 2020

AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells.

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12 December 2020

Design and discovery of small molecules targeting raf-1 kinase

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12 December 2020

SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma

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12 December 2020

MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

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12 December 2020

The antimetastatic effects of resveratrol on hepatocellular carcinoma through the downregulation of a metastasis-associated protease by SP-1 modulation

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12 December 2020

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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12 December 2020

YAP activation is an early event and a potential therapeutic target in liver cancer development.

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12 December 2020

Cytoplasm-localized SIRT1 enhances apoptosis

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12 December 2020

Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma

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12 December 2020

Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells

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12 December 2020

How shelterin protects mammalian telomeres

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12 December 2020

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

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12 December 2020

Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway

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12 December 2020

MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells

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12 December 2020

Structure and function of nicotinamide mononucleotide adenylyltransferase.

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12 December 2020

SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress

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12 December 2020

Acetylation is indispensable for p53 activation

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12 December 2020

MicroRNAs: genomics, biogenesis, mechanism, and function

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12 December 2020

SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis

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12 December 2020

Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo.

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12 December 2020

Diagnosis and Treatment of Hepatocellular Carcinoma

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12 December 2020

Telomere dysfunction and tumour suppression: the senescence connection

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12 December 2020

SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression

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12 December 2020

SIRT1 and other sirtuins in metabolism

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12 December 2020

Resveratrol helps recovery from fatty liver and protects against hepatocellular carcinoma induced by hepatitis B virus X protein in a mouse model

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12 December 2020

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

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12 December 2020

Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects

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12 December 2020

SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation

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12 December 2020

miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells

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12 December 2020

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

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12 December 2020

Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1

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12 December 2020

SirT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions

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12 December 2020

The tumor suppressor protein menin inhibits NF-κB-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma

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12 December 2020

Expression and role of SIRT1 in hepatocellular carcinoma

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12 December 2020

Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma

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12 December 2020

Resveratrol is not a direct activator of SIRT1 enzyme activity

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12 December 2020

Reversible binding of zinc in Plasmodium falciparum Sir2: structure and activity of the apoenzyme

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12 December 2020

MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1.

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12 December 2020

FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states

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12 December 2020

Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

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12 December 2020

Resveratrol interferes with N-nitrosodiethylamine-induced hepatocellular carcinoma at early and advanced stages in male Wistar rats

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12 December 2020

Safety and Efficacy of Sorafenib in Patients with Hepatocellular Carcinoma (HCC) and Child-Pugh A versus B Cirrhosis

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12 December 2020

Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.

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12 December 2020

Switching and signaling at the telomere

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12 December 2020

MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1.

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12 December 2020

Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma

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12 December 2020

A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition

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12 December 2020

Targeted therapy of hepatocellular cancer.

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12 December 2020

Hepatocellular carcinoma: epidemiology and molecular carcinogenesis

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12 December 2020

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

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12 December 2020

Decade in review-hepatocellular carcinoma: HCC-subtypes, stratification and sorafenib

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12 December 2020

Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells.

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12 December 2020

Structure of the histone deacetylase SIRT2

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12 December 2020

Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma

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12 December 2020

Modulation of miR-29 expression by α-fetoprotein is linked to the hepatocellular carcinoma epigenome.

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12 December 2020

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

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12 December 2020

Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.

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12 December 2020

Surfing the p53 network

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12 December 2020

Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells

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12 December 2020

Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma

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12 December 2020

Structural basis for the mechanism and regulation of Sir2 enzymes.

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12 December 2020

Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2

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12 December 2020

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

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12 December 2020

New global survey shows an increasing cancer burden

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12 December 2020

Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States

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12 December 2020

Bile acids activate YAP to promote liver carcinogenesis

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12 December 2020

10.1007/S13277-015-3488-X

Identifiers

DOI

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Dimensions Publication ID

3 September 2017

1002740195

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