Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system (Q38530641)

3 September 2017

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title

Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system (English)

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3 September 2017

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26085215%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Katsuhiro Sasaki

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26085215%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

publication date

1 July 2015

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3 September 2017

Immunological Reviews

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26085215%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

266

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26085215%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26085215%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

175-189

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26085215%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

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Recognition of the polyubiquitin proteolytic signal

21 January 2018

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Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk

21 January 2018

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Recognition and processing of ubiquitin-protein conjugates by the proteasome

21 January 2018

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Proteasome-independent functions of ubiquitin in endocytosis and signaling

21 January 2018

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The multiple layers of ubiquitin-dependent cell cycle control.

21 January 2018

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Ubiquitin in the immune system

21 January 2018

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The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein

21 January 2018

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Regulatory mechanisms involved in the control of ubiquitin homeostasis

21 January 2018

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The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

21 January 2018

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Ubiquitin--conserved protein or selfish gene?

21 January 2018

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RING domain E3 ubiquitin ligases

21 January 2018

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Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

21 January 2018

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Building ubiquitin chains: E2 enzymes at work

21 January 2018

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Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes

21 January 2018

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Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages.

21 January 2018

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Structural aspects of ubiquitin binding specificities.

21 January 2018

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Ubiquitin-binding domains

21 January 2018

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21 January 2018

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Nonproteolytic functions of ubiquitin in cell signaling

21 January 2018

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Ubiquitin-binding domains - from structures to functions

21 January 2018

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Ubiquitin-binding domains

21 January 2018

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Breaking the chains: structure and function of the deubiquitinases

21 January 2018

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Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes

21 January 2018

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Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

21 January 2018

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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

21 January 2018

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A ubiquitin ligase complex assembles linear polyubiquitin chains

21 January 2018

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Met1-linked ubiquitination in immune signalling

21 January 2018

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Diverse ubiquitin signaling in NF-κB activation

21 January 2018

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Linear ubiquitin chains: NF-κB signalling, cell death and beyond.

21 January 2018

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Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

21 January 2018

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Ubiquitination in disease pathogenesis and treatment

21 January 2018

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Detecting and measuring cotranslational protein degradation in vivo

21 January 2018

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A proteomics approach to understanding protein ubiquitination

21 January 2018

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Linear ubiquitination prevents inflammation and regulates immune signalling

21 January 2018

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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

21 January 2018

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RBR E3 ubiquitin ligases: new structures, new insights, new questions

21 January 2018

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Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP

21 January 2018

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The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

21 January 2018

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A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex

21 January 2018

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LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

21 January 2018

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Generation and physiological roles of linear ubiquitin chains

21 January 2018

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Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

21 January 2018

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OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

21 January 2018

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OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

21 January 2018

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The Structure and Conformation of Lys63-Linked Tetraubiquitin

21 January 2018

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Structure of a compact conformation of linear diubiquitin

21 January 2018

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CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes

21 January 2018

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

21 January 2018

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Regulation of NF-κB by deubiquitinases

21 January 2018

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Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

21 January 2018

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Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells.

21 January 2018

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HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death.

21 January 2018

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Ultrastructure of epidermis of mice with chronic proliferative dermatitis

21 January 2018

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Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice

21 January 2018

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Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling

21 January 2018

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Abnormal lymphoid organ development in immunodeficient mutant mice.

21 January 2018

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Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

21 January 2018

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The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

21 January 2018

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Identification of the familial cylindromatosis tumour-suppressor gene

21 January 2018

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Genetics of skin appendage neoplasms and related syndromes

21 January 2018

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Reduced expression of CYLD in human colon and hepatocellular carcinomas

21 January 2018

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Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

21 January 2018

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

21 January 2018

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Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer.

21 January 2018

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Caspase 8 inhibits programmed necrosis by processing CYLD

21 January 2018

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Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila

21 January 2018

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Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.

21 January 2018

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TNF-alpha induces two distinct caspase-8 activation pathways

21 January 2018

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Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.

21 January 2018

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Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

21 January 2018

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Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

21 January 2018

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

21 January 2018

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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

21 January 2018

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

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Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

21 January 2018

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Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.

21 January 2018

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Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

21 January 2018

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beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta

21 January 2018

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Target specificity of the E3 ligase LUBAC for ubiquitin and NEMO relies on different minimal requirements.

21 January 2018

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 January 2018

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Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

21 January 2018

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Mechanism Underlying I B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly Complex

21 January 2018

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Molecular Basis and Regulation of OTULIN-LUBAC Interaction

21 January 2018

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Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling

21 January 2018

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Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

21 January 2018

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A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

21 January 2018

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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

21 January 2018

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

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Linear ubiquitination-mediated NF-κB regulation and its related disorders

21 January 2018

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The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

21 January 2018

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Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

21 January 2018

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Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains

21 January 2018

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MyD88: a central player in innate immune signaling

21 January 2018

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A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells.

21 January 2018

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

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Signaling to NF-kappaB: regulation by ubiquitination

21 January 2018

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Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

21 January 2018

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The role of ubiquitin in NF-kappaB regulatory pathways.

21 January 2018

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IκB kinase regulation of the TPL-2/ERK MAPK pathway

21 January 2018

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IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400

21 January 2018

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Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

21 January 2018

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TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

21 January 2018

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Death receptor activation complexes: it takes two to activate TNF receptor 1

21 January 2018

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Signal transduction by tumor necrosis factor receptors

21 January 2018

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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

21 January 2018

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c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

21 January 2018

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

21 January 2018

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

21 January 2018

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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

21 January 2018

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Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.

21 January 2018

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Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

21 January 2018

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The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells.

21 January 2018

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Response of host inflammasomes to viral infection

21 January 2018

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Mechanisms of NOD-like receptor-associated inflammasome activation

21 January 2018

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The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.

21 January 2018

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Viral RNA detection by RIG-I-like receptors

21 January 2018

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A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response

21 January 2018

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Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex

21 January 2018

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MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

21 January 2018

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Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction

21 January 2018

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Distinct consequences of posttranslational modification by linear versus K63-linked polyubiquitin chains

21 January 2018

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SHARPIN regulates uropod detachment in migrating lymphocytes

21 January 2018

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SHARPIN is an endogenous inhibitor of β1-integrin activation

21 January 2018

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HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth

21 January 2018

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Necroptosis and its role in inflammation

21 January 2018

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Inflammatory outcomes of apoptosis, necrosis and necroptosis

21 January 2018

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IFN-γ or IFN-α ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.

21 January 2018

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Function and activation of NF-kappa B in the immune system

21 January 2018

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B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development.

21 January 2018

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Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms

21 January 2018

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Polyglucosan body myopathy caused by defective ubiquitin ligase RBCK1

21 January 2018

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Whole-genome DNA/RNA sequencing identifies truncating mutations in RBCK1 in a novel Mendelian disease with neuromuscular and cardiac involvement

21 January 2018

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Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

21 January 2018

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E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

21 January 2018

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Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC).

21 January 2018

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Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

21 January 2018

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Mutations of optineurin in amyotrophic lateral sclerosis

21 January 2018

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Adult-onset primary open-angle glaucoma caused by mutations in optineurin

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12308

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26085215%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

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