Forging a signature of in vivo senescence (Q38536371)

3 September 2017

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title

Forging a signature of in vivo senescence (English)

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Erratum: Forging a signature of in vivo senescence

3 September 2017

corrigendum / erratum

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12 July 2019

http://api.crossref.org/works?select=update-to&filter=doi:10.1038/NRC3988

author

Norman Sharpless

series ordinal

1

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3 September 2017

Charles J Sherr

2

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3 September 2017

language of work or name

English

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publication date

1 July 2015

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3 September 2017

published in

Nature Reviews Cancer

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3 September 2017

volume

15

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3 September 2017

issue

7

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3 September 2017

page(s)

397-408

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The serial cultivation of human diploid cell strains

3 September 2017

cites work

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

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Telomeres shorten during ageing of human fibroblasts

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Extension of life-span by introduction of telomerase into normal human cells

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

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p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

31 March 2020

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

31 March 2020

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Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

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Cellular senescence: mitotic clock or culture shock?

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The essence of senescence

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Four faces of cellular senescence.

31 March 2020

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Aging, cellular senescence, and cancer

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Cellular senescence in cancer and aging

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The regulation of INK4/ARF in cancer and aging

31 March 2020

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A role for both RB and p53 in the regulation of human cellular senescence

31 March 2020

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

31 March 2020

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Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

31 March 2020

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G1 events and regulation of cell proliferation

31 March 2020

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Inhibitors of mammalian G1 cyclin-dependent kinases

31 March 2020

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Geroconversion: irreversible step to cellular senescence

31 March 2020

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Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit

31 March 2020

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Cellular mechanisms of tumour suppression by the retinoblastoma gene.

31 March 2020

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Emerging roles of RB family: new defense mechanisms against tumor progression

31 March 2020

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Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis

31 March 2020

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

31 March 2020

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Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells

31 March 2020

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WAF1, a potential mediator of p53 tumor suppression

31 March 2020

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

31 March 2020

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p21 is a universal inhibitor of cyclin kinases

31 March 2020

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Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

31 March 2020

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

31 March 2020

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Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

31 March 2020

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

31 March 2020

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Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.

31 March 2020

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The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit

31 March 2020

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Transient activation of p53 in G2 phase is sufficient to induce senescence.

31 March 2020

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

31 March 2020

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Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

31 March 2020

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Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

31 March 2020

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Necessary and sufficient role for a mitosis skip in senescence induction

31 March 2020

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Senescence from G2 arrest, revisited

31 March 2020

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Defining cellular senescence in IMR-90 cells: a flow cytometric analysis

31 March 2020

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Replicatively senescent cells are arrested in G1 and G2 phases

31 March 2020

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Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis

31 March 2020

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Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

31 March 2020

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The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

31 March 2020

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Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

31 March 2020

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DNA damage associated with mitosis and cytokinesis failure

31 March 2020

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

31 March 2020

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

31 March 2020

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

31 March 2020

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

31 March 2020

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

31 March 2020

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DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

31 March 2020

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Stable cellular senescence is associated with persistent DDR activation

31 March 2020

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

31 March 2020

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Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay

31 March 2020

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Senescence-associated beta-galactosidase is lysosomal beta-galactosidase

31 March 2020

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Induction of endogenous beta-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice

31 March 2020

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Beta-galactosidase--an indicator of the maturational stage of mouse and human mononuclear phagocytes

31 March 2020

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Connecting autophagy to senescence in pathophysiology.

31 March 2020

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Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

31 March 2020

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Lysosome-mediated processing of chromatin in senescence.

31 March 2020

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

31 March 2020

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

31 March 2020

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

31 March 2020

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

31 March 2020

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

31 March 2020

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

31 March 2020

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Stressing the cell cycle in senescence and aging

31 March 2020

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Signatures of mutation and selection in the cancer genome

31 March 2020

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The landscape of somatic copy-number alteration across human cancers

31 March 2020

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

31 March 2020

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Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.

31 March 2020

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p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

31 March 2020

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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

31 March 2020

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p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.

31 March 2020

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Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development

31 March 2020

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Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.

31 March 2020

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Induction of p16 during immortalization by HPV 16 and 18 and not during malignant transformation

31 March 2020

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The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments

31 March 2020

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Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals

31 March 2020

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

31 March 2020

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An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA

31 March 2020

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Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model

31 March 2020

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Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

31 March 2020

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Ink4a/Arf expression is a biomarker of aging

31 March 2020

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The number of p16INK4a positive cells in human skin reflects biological age.

31 March 2020

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p16INK4a reporter mice reveal age-promoting effects of environmental toxicants

31 March 2020

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Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture

31 March 2020

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Cellular senescence controls fibrosis in wound healing

31 March 2020

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The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

31 March 2020

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Induction of CD56 and TCR-independent activation of T cells with aging.

31 March 2020

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Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging

31 March 2020

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Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes

31 March 2020

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Mechanisms that limit the in vitro proliferative potential of human CD8+ T lymphocytes

31 March 2020

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Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence

31 March 2020

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A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

31 March 2020

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Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer

31 March 2020

1 reference

Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy

31 March 2020

1 reference

Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.

31 March 2020

1 reference

KLRG1 impairs CD4+ T cell responses via p16ink4a and p27kip1 pathways: role in hepatitis B vaccine failure in individuals with hepatitis C virus infection

31 March 2020

1 reference

Reversible senescence in human CD4+CD45RA+CD27- memory T cells

31 March 2020

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Tumor suppressor mechanisms in immune aging

31 March 2020

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Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

31 March 2020

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A DNA damage checkpoint response in telomere-initiated senescence

31 March 2020

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DNA damage foci at dysfunctional telomeres

31 March 2020

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Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

31 March 2020

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An oncogene-induced DNA damage model for cancer development

31 March 2020

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

31 March 2020

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Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock

31 March 2020

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Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).

31 March 2020

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Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

31 March 2020

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Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci

31 March 2020

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Sibling rivalry in the E2F family

31 March 2020

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Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation

31 March 2020

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High-order chromatin structure and the epigenome in SAHFs

31 March 2020

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Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

31 March 2020

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence

31 March 2020

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

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Senescence of activated stellate cells limits liver fibrosis

31 March 2020

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Non-cell-autonomous tumor suppression by p53.

31 March 2020

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

31 March 2020

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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

31 March 2020

1 reference

Human regulatory T cells induce T-lymphocyte senescence

31 March 2020

1 reference

T-helper-1-cell cytokines drive cancer into senescence

31 March 2020

1 reference

Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging

31 March 2020

1 reference

Interleukin-6 and its receptors: a highly regulated and dynamic system

31 March 2020

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Gene of the month: Interleukin 6 (IL-6).

31 March 2020

1 reference

Structure and function of telomeres

31 March 2020

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31 March 2020

Telomeres and disease

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Telomeres and telomerase in cancer

31 March 2020

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Role of telomeres and telomerase in cancer

31 March 2020

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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

31 March 2020

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Telomeres and age-related disease: how telomere biology informs clinical paradigms

31 March 2020

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Telomere length measurement-caveats and a critical assessment of the available technologies and tools

31 March 2020

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Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

31 March 2020

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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

31 March 2020

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Tumour biology: senescence in premalignant tumours

31 March 2020

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Programmed cell senescence during mammalian embryonic development

31 March 2020

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Senescence is a developmental mechanism that contributes to embryonic growth and patterning

31 March 2020

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Senescence-associated β-galactosidase activity marks the visceral endoderm of mouse embryos but is not indicative of senescence

31 March 2020

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Arf tumor suppressor and miR-205 regulate cell adhesion and formation of extraembryonic endoderm from pluripotent stem cells

31 March 2020

1 reference

BRAFE600-associated senescence-like cell cycle arrest of human naevi

31 March 2020

1 reference

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

31 March 2020

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Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

31 March 2020

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mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation

31 March 2020

1 reference

How stem cells age and why this makes us grow old.

31 March 2020

1 reference

Cellular senescence: from physiology to pathology

31 March 2020

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Ageing as developmental decay: insights from p16(INK4a.).

31 March 2020

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The role of senescent cells in ageing

31 March 2020

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Mechanisms that regulate stem cell aging and life span

31 March 2020

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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

31 March 2020

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p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis

31 March 2020

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Cellular senescence in aging primates.

31 March 2020

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Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty

31 March 2020

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p16INK4a induces an age-dependent decline in islet regenerative potential

31 March 2020

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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

31 March 2020

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

31 March 2020

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PDGF signalling controls age-dependent proliferation in pancreatic β-cells

31 March 2020

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Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

31 March 2020

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Geriatric muscle stem cells switch reversible quiescence into senescence.

31 March 2020

1 reference

Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a

31 March 2020

1 reference

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

31 March 2020

1 reference

Review: a meta-analysis of GWAS and age-associated diseases

31 March 2020

1 reference

Ink4-Arf locus in cancer and aging

31 March 2020

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The molecular balancing act of p16(INK4a) in cancer and aging

31 March 2020

1 reference

Alternative lengthening of telomeres in mammalian cells

31 March 2020

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Assembly of telomeric chromatin to create ALTernative endings

31 March 2020

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Interchromosomal homology searches drive directional ALT telomere movement and synapsis.

31 March 2020

1 reference

Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a

31 March 2020

1 reference

Characterization of novel markers of senescence and their prognostic potential in cancer.

31 March 2020

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Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.

31 March 2020

1 reference

12 December 2020

Beta-galactosidase staining on bone marrow. The osteoclast pitfall

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12 December 2020

Proliferation and apoptosis of human T cells during replicative senescence--a critical approach.

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12 December 2020

Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.

1 reference

12 December 2020

Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells

1 reference

12 December 2020

A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3960

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Dimensions Publication ID

3 September 2017

1001102257

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