BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models (Q38739375)

6 September 2017

title

BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models (English)

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Amaury E Fernández-Montalván

6 September 2017

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11

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1 June 2020

author name string

Oliver Politz

1

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1 June 2020

Franziska Siegel

2

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1 June 2020

Lars Bärfacker

3

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1 June 2020

Ulf Bömer

4

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1 June 2020

Andrea Hägebarth

5

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1 June 2020

William J Scott

6

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1 June 2020

Martin Michels

7

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1 June 2020

Stuart Ince

8

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1 June 2020

Roland Neuhaus

9

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1 June 2020

Kirstin Meyer

10

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1 June 2020

Ningshu Liu

12

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1 June 2020

Franz von Nussbaum

13

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1 June 2020

Dominik Mumberg

14

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Karl Ziegelbauer

15

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1 June 2020

language of work or name

English

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publication date

3 October 2016

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International Journal of Cancer

6 September 2017

published in

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1 June 2020

volume

140

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1 June 2020

issue

2

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1 June 2020

page(s)

449-459

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AKT/PKB signaling: navigating downstream

1 June 2020

cites work

1 reference

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 January 2018

1 reference

mTOR signaling in growth control and disease

21 January 2018

1 reference

Exploiting the PI3K/AKT pathway for cancer drug discovery

21 January 2018

1 reference

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

21 January 2018

1 reference

Signaling intricacies take center stage in cancer cells

21 January 2018

1 reference

The PI3K pathway as drug target in human cancer

21 January 2018

1 reference

Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.

21 January 2018

1 reference

Systems biology of the metabolic network regulated by the Akt pathway

21 January 2018

1 reference

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

21 January 2018

1 reference

The activation of Akt/PKB signaling pathway and cell survival.

21 January 2018

1 reference

Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

21 January 2018

1 reference

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

1 reference

Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

21 January 2018

1 reference

The PI3K/AKT/mTOR interactive pathway.

21 January 2018

1 reference

NOTCH and PTEN in prostate cancer

21 January 2018

1 reference

PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control

21 January 2018

1 reference

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

21 January 2018

1 reference

Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers

21 January 2018

1 reference

PIK3CA amplification associates with resistance to chemotherapy in ovarian cancer patients.

21 January 2018

1 reference

Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy.

21 January 2018

1 reference

Akt inhibitors in clinical development for the treatment of cancer

21 January 2018

1 reference

Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway

21 January 2018

1 reference

Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor

21 January 2018

1 reference

Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models

21 January 2018

1 reference

Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background

21 January 2018

1 reference

4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

21 January 2018

1 reference

Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA.

21 January 2018

1 reference

Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice

21 January 2018

1 reference

Isolation and characterization of a new human breast cancer cell line, KPL-4, expressing the Erb B family receptors and interleukin-6.

21 January 2018

1 reference

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

21 January 2018

1 reference

BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models

21 January 2018

1 reference

Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer

21 January 2018

1 reference

AKT1(E17K) in human solid tumours

21 January 2018

1 reference

Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression

21 January 2018

1 reference

Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway

21 January 2018

1 reference

Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer

21 January 2018

1 reference

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer

21 January 2018

1 reference

The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

21 January 2018

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2-Deoxy-2-[18F]fluoro-D-glucose positron emission tomography demonstrates target inhibition with the potential to predict anti-tumour activity following treatment with the AKT inhibitor AZD5363.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IJC.30457

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27699769%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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