Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers (Q38740928)

18 June 2018

title

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers (English)

1 reference

18 June 2018

1 reference

Ernst Lengyel

4

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Jason W. Locasale

object named as

Jason W Locasale

5

0 references

Iris L Romero

object named as

Iris L Romero

2

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author name string

Xiaojing Liu

1

1 reference

18 June 2018

Lacey M Litchfield

3

1 reference

18 June 2018

language of work or name

1 reference

13 October 2016

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18 June 2018

published in

Cell Metabolism

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18 June 2018

volume

24

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18 June 2018

issue

5

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18 June 2018

page(s)

728-739

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18 June 2018

Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial.

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23 June 2018

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23 June 2018

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Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

23 June 2018

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Mitochondrial ROS signaling in organismal homeostasis

23 June 2018

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Extreme Outlier Analysis Identifies Occult Mitogen-Activated Protein Kinase Pathway Mutations in Patients With Low-Grade Serous Ovarian Cancer

23 June 2018

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23 June 2018

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Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.

23 June 2018

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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

23 June 2018

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Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer

23 June 2018

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Metformin in breast cancer - an evolving mystery

23 June 2018

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Defining the metabolome: size, flux, and regulation

23 June 2018

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High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet

23 June 2018

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Targeting mitochondria metabolism for cancer therapy

23 June 2018

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Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels

23 June 2018

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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

23 June 2018

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Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

23 June 2018

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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

23 June 2018

1 reference

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Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

23 June 2018

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

23 June 2018

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Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib

23 June 2018

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Development and quantitative evaluation of a high-resolution metabolomics technology

23 June 2018

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Metformin--mode of action and clinical implications for diabetes and cancer

23 June 2018

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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

23 June 2018

1 reference

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Epithelial ovarian cancer experimental models.

23 June 2018

1 reference

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Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

23 June 2018

1 reference

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

23 June 2018

1 reference

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

23 June 2018

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Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.

23 June 2018

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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

23 June 2018

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Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis.

23 June 2018

1 reference

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Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

23 June 2018

1 reference

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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

23 June 2018

1 reference

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889952

Metformin and reduced risk of cancer in diabetic patients

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889952

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889952

Role of AMP-activated protein kinase in mechanism of metformin action

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889952

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889952

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889952

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889952

A most exceptional response

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27746051

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CMET.2016.09.005

1 reference

18 June 2018

PMCID

5889952

1 reference

18 June 2018

PubMed ID

27746051

1 reference

18 June 2018