Convertible visceral fat as a therapeutic target to curb obesity. (Q38769110)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26965204%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Convertible visceral fat as a therapeutic target to curb obesity (English)

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10 March 2020

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1

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3

Saverio Cinti

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10 March 2020

author name string

Andrea Frontini

series ordinal

2

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publication date

11 March 2016

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Nature Reviews Drug Discovery

10 March 2020

published in

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10 March 2020

volume

15

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page(s)

405-424

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10 March 2020

issue

6

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https://scigraph.springernature.com/pub.10.1038/nrd.2016.31

10 March 2020

exact match

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Challenges in β(3)-Adrenoceptor Agonist Drug Development

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Nebivolol induces, via β3 adrenergic receptor, lipolysis, uncoupling protein 1, and reduction of lipid droplet size in human adipocytes.

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A transgenic model of visceral obesity and the metabolic syndrome

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Emerging cardiovascular indications of mineralocorticoid receptor antagonists

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

The protein kinase IKKepsilon regulates energy balance in obese mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Immune regulation of metabolic homeostasis in health and disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Immunohistochemical identification of the beta(3)-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Transcriptional control of brown adipocyte development and physiological function--of mice and men.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Essential role for miR-196a in brown adipogenesis of white fat progenitor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Instruction of mesenchymal cell fate by the transcription factor C/EBPβ.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

EBF2 determines and maintains brown adipocyte identity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

MyomiR-133 regulates brown fat differentiation through Prdm16.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

RIP140-targeted repression of gene expression in adipocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

HOX gene network is involved in the transcriptional regulation of in vivo human adipogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

MicroRNA networks regulate development of brown adipocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

How were new medicines discovered?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Target profiling of small molecules by chemical proteomics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

How chemoproteomics can enable drug discovery and development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

White-to-brown metabolic conversion of human adipocytes by JAK inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Metabolite profiles and the risk of developing diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Molecular aspects of adipoepithelial transdifferentiation in mouse mammary gland.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

In vivo physiological transdifferentiation of adult adipose cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Obesity alters adipose tissue macrophage iron content and tissue iron distribution.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Fibrosis and adipose tissue dysfunction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Activated type 2 innate lymphoid cells regulate beige fat biogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Pharmacological management of obesity: an endocrine Society clinical practice guideline.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Medical treatment of obesity: the past, the present and the future

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Antiobesity pharmacotherapy: new drugs and emerging targets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Neural control of energy balance: translating circuits to therapies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Energy balance and metabolic changes with sodium-glucose co-transporter 2 inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Molecular characterization of the human beta 3-adrenergic receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

The arrestin domain-containing 3 protein regulates body mass and energy expenditure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Cardiotrophin-1 is a key regulator of glucose and lipid metabolism.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

LXRs regulate the balance between fat storage and oxidation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Mir193b-365 is essential for brown fat differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Transcriptional control of brown fat determination by PRDM16

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Pten positively regulates brown adipose function, energy expenditure, and longevity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Nuclear receptor corepressor RIP140 regulates fat accumulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

The K+ channel TASK1 modulates β-adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.31

Obesity, inflammation and endothelial dysfunction.

31 March 2020

1 reference

12 December 2020

Relationship of anthropometric measurements of body fat distribution to metabolic profile in premenopausal women

1 reference

12 December 2020

Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

1 reference

12 December 2020

Regional variation in adipose tissue metabolism of severely obese premenopausal women.

1 reference

12 December 2020

Long-term testosterone administration increases visceral fat in female to male transsexuals.

1 reference

12 December 2020

Treatment of visceral fat obesity

1 reference

12 December 2020

Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization

1 reference

12 December 2020

Rat interscapular brown adipose tissue at different ages: a morphometric study

1 reference

12 December 2020

A morphological study of the adipocyte precursor

1 reference

12 December 2020

The role of perivascular adipose tissue in vasoconstriction, arterial stiffness, and aneurysm.

1 reference

12 December 2020

Defective brown adipose tissue thermogenesis in obese mice

1 reference

12 December 2020

Perivascular adipose tissue, inflammation and insulin resistance: link to vascular dysfunction and cardiovascular disease

1 reference

12 December 2020

Electron microscopical studies on the genesis of white adipocytes: Differentiation of immature pericytes into adipocytes in transplanted preadipose tissue

1 reference

12 December 2020

Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD.2016.31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26965204%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference