An overview of rapamycin: from discovery to future perspectives (Q38822715)

6 September 2017

1 reference

title

An overview of rapamycin: from discovery to future perspectives (English)

1 reference

6 September 2017

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613310%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Young Ji Yoo

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613310%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Sung Ryeol Park

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613310%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Yeo Joon Yoon

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613310%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

publication date

9 September 2016

1 reference

Journal of Industrial Microbiology & Biotechnology

6 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613310%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613310%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

4-5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613310%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

537-553

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613310%20AND%20SRC:MED&resulttype=core&format=json

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

31 May 2020

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Architecture of human mTOR complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Synergistic effect of rapamycin and cisplatin in endometrial cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Draft Genome Sequence of Streptomyces rapamycinicus Strain NRRL 5491, the Producer of the Immunosuppressant Rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin passes the torch: a new generation of mTOR inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Zotarolimus (ABT-578) eluting stents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Generation of high-yield rapamycin-producing strains through protoplasts-related techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Secondary metabolism in simulated microgravity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Genome editing. The new frontier of genome engineering with CRISPR-Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Kinetics of rapamycin production by Streptomyces hygroscopicus MTCC 4003.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Structure of a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin for cardiac transplant rejection and vasculopathy: one stone, two birds?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Current development of mTOR inhibitors as anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Missense mutations at the FKBP12-rapamycin-binding site of TOR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Everolimus: a proliferation signal inhibitor with clinical applications in organ transplantation, oncology, and cardiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Novel sulfur-containing rapamycin analogs prepared by precursor-directed biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin biosynthesis: Elucidation of gene product function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Sequence and transcriptional analysis of the Streptomyces glaucescens tcmAR tetracenomycin C resistance and repressor gene loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

The mechanism of action of cyclosporin A and FK506.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Draft Genome Sequence of Streptomyces iranensis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

CRISPR/Cas, the immune system of bacteria and archaea

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Human brain tumor xenografts in nude mice as a chemotherapy model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Identification of genes that are associated with DNA repeats in prokaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Open-access metabolomics databases for natural product research: present capabilities and future potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Reinvigorating natural product combinatorial biosynthesis with synthetic biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Methionine interference in rapamycin production involves repression of demethylrapamycin methyltransferase and S-adenosylmethionine synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Lifespan extension in genetically modified mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

A family of neuropeptides that inhibit juvenile hormone biosynthesis in the cricket, Gryllus bimaculatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

New rapamycin derivatives by precursor-directed biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

RNA-guided human genome engineering via Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Effects of cyclosporin, FK506, and rapamycin on graft-vessel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Independent assessment of lenvatinib plus everolimus in patients with metastatic renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Ribosome engineering and secondary metabolite production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Calcineurin is required for virulence of Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Incorporation of acetate, propionate, and methionine into rapamycin by Streptomyces hygroscopicus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Temsirolimus, an inhibitor of mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Production of novel rapamycin analogs by precursor-directed biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin in transplantation: a review of the evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Studies on process optimization methods for rapamycin production using Streptomyces hygroscopicus ATCC 29253.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Recent advances in the treatment of mucormycosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

CRISPR-Cas9 Based Engineering of Actinomycetal Genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Structural rearrangements of a polyketide synthase module during its catalytic cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

A high-throughput method for screening of rapamycin-producing strains of Streptomyces hygroscopicus by cultivation in 96-well microtiter plates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

mTOR kinase structure, mechanism and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Everolimus for advanced pancreatic neuroendocrine tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Everolimus plus exemestane in postmenopausal patients with HR(+) breast cancer: BOLERO-2 final progression-free survival analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Structure of the human mTOR complex I and its implications for rapamycin inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Comparative metabolic profiling-based improvement of rapamycin production by Streptomyces hygroscopicus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1834-7

Rapamycin inhibits arterial intimal thickening caused by both alloimmune and mechanical injury. Its effect on cellular, growth factor, and cytokine response in injured vessels

21 January 2018

1 reference

12 December 2020

Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to rapamycin biosynthesis

1 reference

12 December 2020

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

1 reference

12 December 2020

Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase.

1 reference

12 December 2020

Characterization of negative regulatory genes for the biosynthesis of rapamycin in Streptomyces rapamycinicus and its application for improved production

1 reference

12 December 2020

Rapamycin for immunosuppression in organ allografting.

1 reference

12 December 2020

Inhibition of the immune response by rapamycin, a new antifungal antibiotic

1 reference

12 December 2020

Comparative analysis of rapamycin biosynthesis clusters between Actinoplanes sp. N902-109 and Streptomyces hygroscopicus ATCC29253

1 reference

12 December 2020

Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells

1 reference

12 December 2020

Rapamycin reverses chronic graft vascular disease in a novel cardiac allograft model

1 reference

12 December 2020

Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation

1 reference

12 December 2020

Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus

1 reference

12 December 2020

Growth of Steptomyces hygroscopicus in rotating-wall bioreactor under simulated microgravity inhibits rapamycin production

1 reference

12 December 2020

Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis

1 reference

12 December 2020

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization

1 reference

12 December 2020

lipase-catalyzed regioselective esterification of rapamycin: synthesis of temsirolimus (CCI-779)

1 reference

12 December 2020

Mutagenesis of the rapamycin producer Streptomyces hygroscopicus FC904.

1 reference

12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

12 December 2020

Generation of novel rapamycin structures by microbial manipulations

1 reference

12 December 2020

Effect of nitrogen source on biosynthesis of rapamycin by Streptomyces hygroscopicus

1 reference

12 December 2020

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

1 reference

12 December 2020

Effect of sirolimus in combination with low-dose cyclosporine and steroids on acute renal allograft rejection

1 reference

12 December 2020

Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin

1 reference

12 December 2020

Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus

1 reference

12 December 2020

In Vitro CRISPR/Cas9 System for Efficient Targeted DNA Editing

1 reference

12 December 2020

Antifungal activities of rapamycin and its derivatives, prolylrapamycin, 32-desmethylrapamycin, and 32-desmethoxyrapamycin.

1 reference

12 December 2020

SnapShot: Ca2+-calcineurin-NFAT signaling

1 reference

12 December 2020

Activity of rapamycin (AY-22,989) against transplanted tumors

1 reference

12 December 2020

Effects of dissolved oxygen level on rapamycin production by pellet-form of Streptomyces hygroscopicus

1 reference

12 December 2020

Improvement of microbial strain and fermentation process of rapamycin biosynthesis

1 reference

12 December 2020

Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue.

1 reference

12 December 2020

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.727

Identifiers

DOI

10.1007/S10295-016-1834-7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27613310%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference