Structures of androgen receptor bound with ligands: advancing understanding of biological functions and drug discovery (Q38838223)

6 September 2017

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title

Structures of androgen receptor bound with ligands: advancing understanding of biological functions and drug discovery (English)

1 reference

6 September 2017

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3

Weida Tong

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6 September 2017

Sugunadevi Sakkiah

1

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6 September 2017

Hui Wen Ng

series ordinal

2

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6 September 2017

Huixiao Hong

series ordinal

4

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6 September 2017

language of work or name

English

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publication date

19 May 2016

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Expert Opinion on Therapeutic Targets

6 September 2017

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6 September 2017

20

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6 September 2017

1267-1282

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6 September 2017

10

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The androgen receptor in health and disease

6 September 2017

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Cloning of Human Androgen Receptor Complementary DNA and Localization to the X Chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Biological Actions of Androgens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

A unified nomenclature system for the nuclear receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Principles for modulation of the nuclear receptor superfamily

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

An amphioxus orthologue of the estrogen receptor that does not bind estradiol: insights into estrogen receptor evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Overview of nomenclature of nuclear receptors

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Chemical approaches to nuclear receptors in metabolism

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

The nuclear receptor superfamily: the second decade

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Androgen receptor: structure, role in prostate cancer and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

The EDKB: an established knowledge base for endocrine disrupting chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Homology modeling, molecular docking, and molecular dynamics simulations elucidated α-fetoprotein binding modes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

EADB: an estrogenic activity database for assessing potential endocrine activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Competitive molecular docking approach for predicting estrogen receptor subtype α agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Estrogenic activity data extraction and in silico prediction show the endocrine disruption potential of bisphenol A replacement compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Development and Validation of Decision Forest Model for Estrogen Receptor Binding Prediction of Chemicals Using Large Data Sets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Disruption of androgen receptor signaling in males by environmental chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Endocrine-disrupting chemicals: an Endocrine Society scientific statement

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Specific, nongenomic actions of steroid hormones

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Non-genomic actions of androgens.

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Polyglutamines placed into context

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Allosteric conversation in the androgen receptor ligand-binding domain surfaces.

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural organization of the human androgen receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Cloning, structure and expression of a cDNA encoding the human androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

The contribution of different androgen receptor domains to receptor dimerization and signaling

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Mechanism of androgen receptor action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Comparative molecular field analysis (CoMFA) model using a large diverse set of natural, synthetic and environmental chemicals for binding to the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Androgen action and metabolism in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural characterization of the native NH2-terminal transactivation domain of the human androgen receptor: a collapsed disordered conformation underlies structural plasticity and protein-induced folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Consequences of poly-glutamine repeat length for the conformation and folding of the androgen receptor amino-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Conformational analysis of the androgen receptor amino-terminal domain involved in transactivation. Influence of structure-stabilizing solutes and protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Analysis of interdomain interactions of the androgen receptor

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Identification of two transcription activation units in the N-terminal domain of the human androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Modulation of Androgen Receptor Activation Function 2 by Testosterone and Dihydrotestosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Novel DNA-binding element within the C-terminal extension of the nuclear receptor DNA-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Steroid hormone receptors: many actors in search of a plot

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Change of specificity mutations in androgen-selective enhancers. Evidence for a role of differential DNA binding by the androgen receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural basis of androgen receptor binding to selective androgen response elements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Nuclear import of the human androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Androgen receptors in endocrine-therapy-resistant human prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

The antiovulatory effect of the antiprogestin onapristone could be related to down-regulation of intraovarian progesterone (receptors).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Roles of androgens in the development, growth, and carcinogenesis of the mammary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Requirement for math5 in the development of retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

The expansion of the CAG repeat in exon 1 of the human androgen receptor gene is associated with uterine endometrial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Molecular basis of androgen insensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Nuclear receptors and disease: androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

The role of androgen receptor mutations in prostate cancer progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Localization of functional domains in the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Acetylation of nuclear receptors in cellular growth and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Primary structure and expression of a functional human glucocorticoid receptor cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural basis for antagonism and resistance of bicalutamide in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Nuclear receptor mediated gene regulation through chromatin remodeling and histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

The human estrogen receptor has two independent nonacidic transcriptional activation functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

An interpretation of positional displacement of the helix12 in nuclear receptors: preexistent swing-up motion triggered by ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Discovery of non-LBD inhibitor for androgen receptor by structure-guide design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

A conserved surface on the ligand binding domain of nuclear receptors for allosteric control

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

A surface on the androgen receptor that allosterically regulates coactivator binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

MicroRNAs are mediators of androgen action in prostate and muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Mini-review: Foldosome regulation of androgen receptor action in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Maintaining and reprogramming genomic androgen receptor activity in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Molecular pathways: targeting resistance in the androgen receptor for therapeutic benefit

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Drug insight: testosterone preparations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Molecular chaperones throughout the life cycle of the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Cdc25B functions as a novel coactivator for the steroid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Cyclin E as a coactivator of the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Lessons learnt from structural studies of the oestrogen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural insights into corepressor recognition by antagonist-bound estrogen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Interaction between the androgen receptor and a segment of its corepressor SHP

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Chemistry and structural biology of androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Versatility or promiscuity: the estrogen receptors, control of ligand selectivity and an update on subtype selective ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Clinical trial update and novel therapeutic approaches for metastatic prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Androgen receptor antagonists (antiandrogens): structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

A history of prostate cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Increased survival with enzalutamide in prostate cancer after chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Development of a second-generation antiandrogen for treatment of advanced prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Androgen receptor rediscovered: the new biology and targeting the androgen receptor therapeutically

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Recognition and accommodation at the androgen receptor coactivator binding interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Mechanism of androgen receptor antagonism by bicalutamide in the treatment of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Mechanism of antiandrogen action: conformational changes of the receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Overcoming mutation-based resistance to antiandrogens with rational drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural basis for the glucocorticoid response in a mutant human androgen receptor (AR(ccr)) derived from an androgen-independent prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Structural basis for accommodation of nonsteroidal ligands in the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Targeting the binding function 3 (BF3) site of the androgen receptor through virtual screening. 2. development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

In silico discovery of androgen receptor antagonists with activity in castration resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

Metabolism of Testosterone and Action of Metabolites on Prostate Glands grown in Organ Culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2016.1192131

10.1080/14728222.2016.1192131

21 January 2018

Identifiers

DOI

1 reference

6 September 2017

1 reference