Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway (Q38866973)

7 September 2017

title

Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway (English)

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7 September 2017

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11

Graça Raposo

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7 September 2017

Sylvain Lehmann

8

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Pascal Leblanc

object named as

Pascal Leblanc

12

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Sandrine Alais

object named as

Sandrine Alais

4

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author name string

Didier Vilette

1

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7 September 2017

Karine Laulagnier

2

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7 September 2017

Alvina Huor

3

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7 September 2017

Sabrina Simoes

5

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7 September 2017

Romao Maryse

6

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7 September 2017

Monique Provansal

7

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7 September 2017

Olivier Andreoletti

9

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7 September 2017

Laurent Schaeffer

10

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7 September 2017

publication date

6 June 2015

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Cellular and Molecular Life Sciences

7 September 2017

published in

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7 September 2017

volume

72

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7 September 2017

issue

22

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7 September 2017

page(s)

4409-4427

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

7 September 2017

cites work

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PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP

21 January 2018

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Squalestatin cures prion-infected neurons and protects against prion neurotoxicity.

21 January 2018

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Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation

21 January 2018

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The prion protein requires cholesterol for cell surface localization.

21 January 2018

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Cholesterol balance in prion diseases and Alzheimer's disease

21 January 2018

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Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform

21 January 2018

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Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform

21 January 2018

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Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

21 January 2018

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The highways and byways of prion protein trafficking

21 January 2018

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Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?

21 January 2018

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Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles

21 January 2018

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Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection

21 January 2018

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Prion-infected cells regulate the release of exosomes with distinct ultrastructural features

21 January 2018

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Cells release prions in association with exosomes

21 January 2018

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Retrovirus infection strongly enhances scrapie infectivity release in cell culture

21 January 2018

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Packaging of prions into exosomes is associated with a novel pathway of PrP processing.

21 January 2018

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Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis

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21 January 2018

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Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

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Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis

21 January 2018

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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

21 January 2018

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Exosomes: the future of biomarkers in medicine

21 January 2018

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21 January 2018

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Extracellular vesicles: exosomes, microvesicles, and friends

21 January 2018

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21 January 2018

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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

21 January 2018

1 reference

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21 January 2018

A protein's final ESCRT.

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21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein.

21 January 2018

1 reference

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Ceramide triggers budding of exosome vesicles into multivesicular endosomes

21 January 2018

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The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes

21 January 2018

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The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis

21 January 2018

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Cultured peripheral neuroglial cells are highly permissive to sheep prion infection

21 January 2018

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A simple, versatile and sensitive cell-based assay for prions from various species

21 January 2018

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Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein

21 January 2018

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An essential role of Hrs/Vps27 in endosomal cholesterol trafficking

21 January 2018

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Identification of an intracellular site of prion conversion

21 January 2018

1 reference

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4-hydroxytamoxifen leads to PrPSc clearance by conveying both PrPC and PrPSc to lysosomes independently of autophagy.

21 January 2018

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Tangier disease: epidemiology, pathophysiology, and management

21 January 2018

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Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Prion infection impairs cholesterol metabolism in neuronal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux

21 January 2018

1 reference

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Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Transfer of scrapie prion infectivity by cell contact in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Efficient dissemination of prions through preferential transmission to nearby cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Prions hijack tunnelling nanotubes for intercellular spread

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

The role of exosomes in the processing of proteins associated with neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Paracrine diffusion of PrP(C) and propagation of prion infectivity by plasma membrane-derived microvesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann-Pick type C disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Cholesterol trapping in Niemann-Pick disease type B fibroblasts can be relieved by expressing the phosphotyrosine binding domain of GULP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Rapid cell-surface prion protein conversion revealed using a novel cell system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Cryo-immunogold electron microscopy for prions: toward identification of a conversion site

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

The multivesicular body is the major internal site of prion conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Analysis of the interactions between HIV-1 and the cellular prion protein in a human cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-1945-8

Strategies for isolation of exosomes

21 January 2018

1 reference

12 December 2020

Prion strains are differentially released through the exosomal pathway

1 reference

12 December 2020

Rab27a and Rab27b control different steps of the exosome secretion pathway

1 reference

12 December 2020

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

1 reference

12 December 2020

The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes

1 reference

12 December 2020

Detection of exosomal prions in blood by immunochemistry techniques

1 reference

12 December 2020

10.1007/S00018-015-1945-8

Identifiers

DOI

1 reference

7 September 2017

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