LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease. (Q39137339)

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2 April 2020

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8 October 2022

LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease (English)

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2 April 2020

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Parkinson disease associated proteins

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20 December 2019

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2 April 2020

Sally A. Cowley

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3

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author name string

Heyne Lee

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1 February 2017

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Biochemical Society Transactions

2 April 2020

8 February 2017

1 reference

8 October 2022

6 references

25 April 2019

12 September 2019

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1

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LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase

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The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease

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Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity

15 June 2018

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Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease

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The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

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LRRK2 inhibition attenuates microglial inflammatory responses

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The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

15 June 2018

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Regulation of LRRK2 expression points to a functional role in human monocyte maturation

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Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

15 June 2018

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15 June 2018

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15 June 2018

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15 June 2018

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15 June 2018

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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

15 June 2018

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15 June 2018

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Inflammation is genetically implicated in Parkinson's disease.

15 June 2018

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17 June 2018

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LRRK2 is involved in the IFN-gamma response and host response to pathogens

17 June 2018

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Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.

17 June 2018

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Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells

17 June 2018

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Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques.

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Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity.

21 August 2018

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LRRK2 expression in normal and pathologic human brain and in human cell lines

21 August 2018

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Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally

21 August 2018

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A possible role for humoral immunity in the pathogenesis of Parkinson's disease

21 August 2018

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21 August 2018

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12 December 2020

LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

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12 December 2020

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Interferon-γ induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages

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12 December 2020

Identifiers

DOI

10.1042/BST20160262

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28202666%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28202666%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference