Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways. (Q39260655)

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18 March 2020

title

Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways (English)

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18 March 2020

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18 March 2020

Alireza Sadeghpour

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18 March 2020

Bahman Yousefi

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18 March 2020

author name string

Saeed Mehrzadi

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18 March 2020

Russel J Reiter

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18 March 2020

Nasrin Khatami

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18 March 2020

publication date

18 May 2017

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Journal of Pineal Research

18 March 2020

published in

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18 March 2020

volume

63

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18 March 2020

issue

1

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DNA damage response--a double-edged sword in cancer prevention and cancer therapy

18 March 2020

cites work

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Therapeutic opportunities within the DNA damage response

21 January 2018

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Targeting the DNA damage response in cancer

21 January 2018

1 reference

Non-coding RNAs: an emerging player in DNA damage response

21 January 2018

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DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining

21 January 2018

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DNA damage response regulation by microRNAs as a therapeutic target in cancer

21 January 2018

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The DNA damage response: implications for tumor responses to radiation and chemotherapy

21 January 2018

1 reference

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

21 January 2018

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Extrapineal melatonin: sources, regulation, and potential functions.

21 January 2018

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Update on melatonin receptors: IUPHAR Review 20.

21 January 2018

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Melatonin receptors: molecular biology of a new family of G protein-coupled receptors

21 January 2018

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Melatonin membrane receptors in peripheral tissues: distribution and functions

21 January 2018

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Anatomical and cellular localization of melatonin MT1 and MT2 receptors in the adult rat brain

21 January 2018

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Quinone reductase 2 as a promising target of melatonin therapeutic actions.

21 January 2018

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The nuclear melatonin receptor RORα is a novel endogenous defender against myocardial ischemia/reperfusion injury.

21 January 2018

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Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase.

21 January 2018

1 reference

The orphan receptor family RZR/ROR, melatonin and 5-lipoxygenase: an unexpected relationship

21 January 2018

1 reference

Melatonin and cancer risk: does light at night compromise physiologic cancer protection by lowering serum melatonin levels?

21 January 2018

1 reference

Melatonin, sleep disturbance and cancer risk

21 January 2018

1 reference

Melatonin: an inhibitor of breast cancer

21 January 2018

1 reference

Melatonin: an ancient molecule that makes oxygen metabolically tolerable.

21 January 2018

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Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

21 January 2018

1 reference

Melatonin as an antioxidant: under promises but over delivers

21 January 2018

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Regulation of antioxidant enzymes: a significant role for melatonin

21 January 2018

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Targeting DNA damage response in cancer therapy

21 January 2018

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The DNA-damage response in human biology and disease

21 January 2018

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The DNA damage response: sensing and signaling

21 January 2018

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The DNA damage response and cancer therapy

21 January 2018

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The DNA damage response: ten years after

21 January 2018

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

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Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks

21 January 2018

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A direct role for small non-coding RNAs in DNA damage response

21 January 2018

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Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.

21 January 2018

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DNA damage response genes and the development of cancer metastasis

21 January 2018

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Targeting ATR in DNA damage response and cancer therapeutics.

21 January 2018

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ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.

21 January 2018

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gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

21 January 2018

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

21 January 2018

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

21 January 2018

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

21 January 2018

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Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

21 January 2018

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Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage

21 January 2018

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Interplay of replication checkpoints and repair proteins at stalled replication forks

21 January 2018

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Arrested replication fork processing: interplay between checkpoints and recombination

21 January 2018

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Emerging links between the biological clock and the DNA damage response

21 January 2018

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Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

21 January 2018

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New insights into checkpoint kinase 1 in the DNA damage response signaling network

21 January 2018

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Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer

21 January 2018

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Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

21 January 2018

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Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin

21 January 2018

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Melatonin as a preventive and curative therapy against pulmonary hypertension

21 January 2018

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Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS. Protective effect of melatonin

21 January 2018

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Hepatoprotective actions of melatonin: possible mediation by melatonin receptors

21 January 2018

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Increased levels of oxidatively damaged DNA induced by chromium(III) and H2O2: protection by melatonin and related molecules.

21 January 2018

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Effects of melatonin on paraquat or ultraviolet light exposure-induced DNA damage

21 January 2018

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Preventive effect of melatonin against DNA damage induced by cyanide, kainate, glutathione/Fe(3+)/O(2), or H(2)O(2)/Fe(2+).

21 January 2018

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Melatonin protects against ischemia and reperfusion-induced oxidative lipid and DNA damage in fetal rat brain.

21 January 2018

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Melatonin and N-tert-butyl-alpha-phenylnitrone block 60-Hz magnetic field-induced DNA single and double strand breaks in rat brain cells.

21 January 2018

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Exogenous melatonin supplementation prevents oxidative stress-evoked DNA damage in human spermatozoa.

21 January 2018

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Inhibition of 5-aminolevulinic acid-induced DNA damage by melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, quercetin or resveratrol.

21 January 2018

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The pineal secretory product melatonin reduces hydrogen peroxide-induced DNA damage in U-937 cells

21 January 2018

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Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin.

21 January 2018

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AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice.

21 January 2018

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Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters

21 January 2018

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Melatonin reduces phosphine-induced lipid and DNA oxidation in vitro and in vivo in rat brain

21 January 2018

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Melatonin attenuates phenytoin sodium-induced DNA damage

21 January 2018

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The potential chemoprotective effects of melatonin against genotoxicity induced by diazinon in human peripheral blood lymphocytes

21 January 2018

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Melatonin ameliorates bisphenol A-induced DNA damage in the germ cells of adult male rats.

21 January 2018

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Protective effect of melatonin against hippocampal DNA damage induced by intraperitoneal administration of kainate to rats.

21 January 2018

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Mobile phone radiation induces mode-dependent DNA damage in a mouse spermatocyte-derived cell line: a protective role of melatonin.

21 January 2018

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Effect of melatonin on DNA damage of bovine cumulus cells during in vitro maturation (IVM) and on in vitro embryo development.

21 January 2018

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Comparison of the protective effect of melatonin with other antioxidants in the hamster kidney model of estradiol-induced DNA damage.

21 January 2018

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Protective effect of melatonin against in vitro iron ions and 7 mT 50 Hz magnetic field-induced DNA damage in rat lymphocytes

21 January 2018

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Melatonin protects bovine cerebral endothelial cells from hyperoxia-induced DNA damage and death.

21 January 2018

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DNA oxidatively damaged by chromium(III) and H(2)O(2) is protected by the antioxidants melatonin, N(1)-acetyl-N(2)-formyl-5-methoxykynuramine, resveratrol and uric acid

21 January 2018

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Radioprotective potential of melatonin against ⁶⁰Co γ-ray-induced testicular injury in male C57BL/6 mice

21 January 2018

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Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation.

21 January 2018

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Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double-strand DNA break repair.

21 January 2018

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Regulation of DNA double-strand break repair pathway choice

21 January 2018

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Melatonin protects the integrity of granulosa cells by reducing oxidative stress in nuclei, mitochondria, and plasma membranes in mice

21 January 2018

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The cardioprotective effect of melatonin and exendin-4 treatment in a rat model of cardiorenal syndrome.

21 January 2018

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Melatonin pretreatment enhances the therapeutic effects of exogenous mitochondria against hepatic ischemia-reperfusion injury in rats through suppression of mitochondrial permeability transition.

21 January 2018

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Circadian clock control of the cellular response to DNA damage

21 January 2018

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Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells

21 January 2018

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Does melatonin induce apoptosis in MCF-7 human breast cancer cells in vitro?

21 January 2018

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Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line

21 January 2018

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Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells

21 January 2018

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Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation.

21 January 2018

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Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.

21 January 2018

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Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathways

21 January 2018

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Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions

21 January 2018

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How nucleotide excision repair protects against cancer

21 January 2018

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Neuroprotection by melatonin against ischemic neuronal injury associated with modulation of DNA damage and repair in the rat following a transient cerebral ischemia

21 January 2018

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The modulatory effect of melatonin on genotoxicity of irinotecan in healthy human lymphocytes and cancer cells.

21 January 2018

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A comparison of the action of amifostine and melatonin on DNA-damaging effects and apoptosis induced by idarubicin in normal and cancer cells.

21 January 2018

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p53--a Jack of all trades but master of none

21 January 2018

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Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation

21 January 2018

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Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation of ERK/p90 ribosomal S6 kinase/heat shock protein 27 in SK-OV-3 cells

21 January 2018

1 reference

Synergic Effects of Doxorubicin and Melatonin on Apoptosis and Mitochondrial Oxidative Stress in MCF-7 Breast Cancer Cells: Involvement of TRPV1 Channels

21 January 2018

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Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway

21 January 2018

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Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide-induced urinary bladder injury in rat.

21 January 2018

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Protective effect of melatonin on oxaliplatin-induced apoptosis through sustained Mcl-1 expression and anti-oxidant action in renal carcinoma Caki cells

21 January 2018

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Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis

21 January 2018

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Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin.

21 January 2018

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Rejuvenation of degenerative thymus by oral melatonin administration and the antagonistic action of melatonin against hydroxyl radical-induced apoptosis of cultured thymocytes in mice

21 January 2018

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Melatonin prevents apoptosis induced by 6-hydroxydopamine in neuronal cells: implications for Parkinson's disease.

21 January 2018

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Melatonin reverses H2 O2 -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway.

21 January 2018

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Melatonin mitigates oxidative damage and apoptosis in mouse cerebellum induced by high-LET 56Fe particle irradiation

21 January 2018

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Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis and liver damage induced during malarial infection

21 January 2018

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Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3/casp-7) and PARP in UVR-exposed HaCaT keratinocytes

21 January 2018

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Melatonin reduces amyloid beta-induced apoptosis in pheochromocytoma (PC12) cells

21 January 2018

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Melatonin ameliorates metabolic risk factors, modulates apoptotic proteins, and protects the rat heart against diabetes-induced apoptosis

21 January 2018

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Effect of melatonin on apoptosis, proliferation and differentiation of urothelial cells after cyclophosphamide treatment

21 January 2018

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Protective effect of melatonin on bone marrow mesenchymal stem cells against hydrogen peroxide-induced apoptosis in vitro.

21 January 2018

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Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1.

21 January 2018

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Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells

21 January 2018

1 reference

Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy

21 January 2018

1 reference

Gastrointestinal melatonin: localization, function, and clinical relevance

21 January 2018

1 reference

Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

21 January 2018

1 reference

Oxidative stress and immunosenescence: therapeutic effects of melatonin

21 January 2018

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Melatonin in Alzheimer's disease and other neurodegenerative disorders

21 January 2018

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Melatonin in cancer management: progress and promise

21 January 2018

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Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

21 January 2018

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Melatonin sensitizes H1975 non-small-cell lung cancer cells harboring a T790M-targeted epidermal growth factor receptor mutation to the tyrosine kinase inhibitor gefitinib

21 January 2018

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Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase

21 January 2018

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Effects of melatonin on doxorubicin cytotoxicity in sensitive and pleiotropically resistant tumor cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JPI.12416

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28439991%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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