Enzyme-substrate relationships in the ubiquitin system: approaches for identifying substrates of ubiquitin ligases (Q39271396)

10 September 2017

1 reference

title

Enzyme-substrate relationships in the ubiquitin system: approaches for identifying substrates of ubiquitin ligases (English)

1 reference

10 September 2017

Hazel F O'Connor

1

1 reference

10 September 2017

Jon M Huibregtse

series ordinal

2

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10 September 2017

publication date

28 April 2017

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Cellular and Molecular Life Sciences

10 September 2017

published in

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10 September 2017

volume

74

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10 September 2017

issue

18

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10 September 2017

page(s)

3363-3375

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Systematic approaches to identify E3 ligase substrates

10 September 2017

cites work

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30 August 2018

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The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease

30 August 2018

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Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.

30 August 2018

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Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.

30 August 2018

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Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.

30 August 2018

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Hell's BELs: bacterial E3 ligases that exploit the eukaryotic ubiquitin machinery

30 August 2018

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The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex

30 August 2018

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Ubiquitin is phosphorylated by PINK1 to activate parkin

30 August 2018

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Roles of F-box proteins in cancer

30 August 2018

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BioID: a screen for protein-protein interactions.

30 August 2018

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Ubiquitin ligase trapping identifies an SCF(Saf1) pathway targeting unprocessed vacuolar/lysosomal proteins.

30 August 2018

1 reference

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Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

30 August 2018

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Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.

30 August 2018

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The CRAPome: a contaminant repository for affinity purification-mass spectrometry data

30 August 2018

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Diggin' on u(biquitin): a novel method for the identification of physiological E3 ubiquitin ligase substrates.

30 August 2018

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Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

30 August 2018

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A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis

30 August 2018

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The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator

30 August 2018

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Mutation of HERC2 causes developmental delay with Angelman-like features.

30 August 2018

1 reference

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Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator

30 August 2018

1 reference

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A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder

30 August 2018

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The ubiquitin-proteasome system of Saccharomyces cerevisiae

30 August 2018

1 reference

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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

30 August 2018

1 reference

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Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.

30 August 2018

1 reference

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DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

30 August 2018

1 reference

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A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

30 August 2018

1 reference

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Isolation of ubiquitylated proteins using tandem ubiquitin-binding entities.

30 August 2018

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Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture

30 August 2018

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Nutrient sensing kinases PKA and Sch9 phosphorylate the catalytic domain of the ubiquitin-conjugating enzyme Cdc34.

30 August 2018

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A protein complex network of Drosophila melanogaster

30 August 2018

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Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.

30 August 2018

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Global identification of modular cullin-RING ligase substrates

30 August 2018

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Systematic and quantitative assessment of the ubiquitin-modified proteome

30 August 2018

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The cullin protein family

30 August 2018

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Control of cullin-ring ubiquitin ligase activity by nedd8.

30 August 2018

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A data set of human endogenous protein ubiquitination sites

30 August 2018

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Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling

30 August 2018

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A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network

30 August 2018

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UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex

30 August 2018

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HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

30 August 2018

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Identification of a physiological E2 module for the human anaphase-promoting complex

30 August 2018

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UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

30 August 2018

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Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities

30 August 2018

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Saint: a lightweight integration environment for model annotation

30 August 2018

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Defining the human deubiquitinating enzyme interaction landscape

30 August 2018

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Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.

30 August 2018

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JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation

30 August 2018

1 reference

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Physiological functions of the HECT family of ubiquitin ligases

30 August 2018

1 reference

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Viral avoidance and exploitation of the ubiquitin system.

30 August 2018

1 reference

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Polyubiquitination by HECT E3s and the determinants of chain type specificity

30 August 2018

1 reference

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Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

30 August 2018

1 reference

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Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays

30 August 2018

1 reference

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Identification of SCF ubiquitin ligase substrates by global protein stability profiling

30 August 2018

1 reference

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Global protein stability profiling in mammalian cells

30 August 2018

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Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

30 August 2018

1 reference

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Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling

30 August 2018

1 reference

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

30 August 2018

1 reference

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E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

30 August 2018

1 reference

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A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch.

30 August 2018

1 reference

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Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast

30 August 2018

1 reference

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SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation.

30 August 2018

1 reference

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NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linking

30 August 2018

1 reference

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Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells

30 August 2018

1 reference

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Identification of ubiquitin ligase substrates by in vitro expression cloning

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Function and regulation of cullin-RING ubiquitin ligases

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

A proteomics approach to understanding protein ubiquitination

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Structural insights into the U-box, a domain associated with multi-ubiquitination

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Purification of poly-ubiquitinated proteins by S5a-affinity chromatography

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC.

30 August 2018

1 reference

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Rsp5 WW domains interact directly with the carboxyl-terminal domain of RNA polymerase II.

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Geminin, an inhibitor of DNA replication, is degraded during mitosis

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

Systematic identification of mitotic phosphoproteins

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545068

A High Throughput Screen to Identify Substrates for the Ubiquitin Ligase Rsp5

30 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00018-017-2529-6

Isolation of ubiquitinated substrates by tandem affinity purification of E3 ligase-polyubiquitin-binding domain fusions (ligase traps)

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28455558

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00018-017-2529-6

1 reference

10 September 2017

0 references

1 reference