Inhibition of doxorubicin-induced HER3-PI3K-AKT signalling enhances apoptosis of ovarian cancer cells. (Q39307072)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22841590%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Inhibition of doxorubicin-induced HER3-PI3K-AKT signalling enhances apoptosis of ovarian cancer cells (English)

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9 February 2020

0 references

1 reference

2

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9 February 2020

author name string

Martin Bezler

series ordinal

1

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9 February 2020

Axel Ullrich

series ordinal

3

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publication date

20 July 2012

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9 February 2020

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volume

6

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9 February 2020

issue

5

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9 February 2020

page(s)

516-529

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Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase

9 February 2020

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1 reference

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Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors

11 September 2017

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

11 September 2017

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Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

11 September 2017

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Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy

11 September 2017

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Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells

11 September 2017

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Mechanism of activation and inhibition of the HER4/ErbB4 kinase

11 September 2017

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Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

11 September 2017

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11 September 2017

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Increased expression of pAKT is associated with radiation resistance in cervical cancer

11 September 2017

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Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells.

11 September 2017

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ADAMs: key components in EGFR signalling and development

11 September 2017

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A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

11 September 2017

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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

11 September 2017

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Ovarian cancer: strategies for overcoming resistance to chemotherapy

11 September 2017

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The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

11 September 2017

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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

11 September 2017

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TACE is required for the activation of the EGFR by TGF-alpha in tumors

11 September 2017

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Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability

11 September 2017

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Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

11 September 2017

1 reference

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Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions

11 September 2017

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An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4.

11 September 2017

1 reference

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Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

11 September 2017

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Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3

11 September 2017

1 reference

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Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas

11 September 2017

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Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors

11 September 2017

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Molecular cloning and expression of an additional epidermal growth factor receptor-related gene

11 September 2017

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Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancer

11 September 2017

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Chemoresistant tumor cell lines display altered epidermal growth factor receptor and HER3 signaling and enhanced sensitivity to gefitinib

11 September 2017

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HER3 is a determinant for poor prognosis in melanoma

14 September 2017

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Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death

14 September 2017

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AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway

14 September 2017

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Erlotinib directly inhibits HER2 kinase activation and downstream signaling events in intact cells lacking epidermal growth factor receptor expression

14 September 2017

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Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor

14 September 2017

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Tyrosine phosphorylation of PYK2 mediates heregulin-induced glioma invasion: novel heregulin/HER3-stimulated signaling pathway in glioma.

14 September 2017

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ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528396

Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme

14 September 2017

1 reference

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Biochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor protein

25 September 2017

1 reference

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Comparison of antigen expression on fresh and cultured ascites cells and on solid tumors of patients with epithelial ovarian cancer

25 September 2017

1 reference

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Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors.

15 June 2018

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Metallothionein gene expression and resistance to cisplatin in human ovarian cancer

15 June 2018

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Characterization of an ovarian carcinoma cell line

15 June 2018

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Adriamycin accumulation and metabolism in adriamycin-sensitive and -resistant human ovarian cancer cell lines

15 June 2018

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The activation of Akt during preoperative chemotherapy for esophageal cancer correlates with poor prognosis.

17 June 2018

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Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers

21 August 2018

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ErbB-3 predicts survival in ovarian cancer.

21 August 2018

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Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer

21 August 2018

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Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

21 August 2018

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Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22841590

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An essential role for ectodomain shedding in mammalian development

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22841590

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/22841590

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLONC.2012.07.001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22841590%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

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9 February 2020

PubMed publication ID

22841590

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22841590%20AND%20SRC:MED&resulttype=core&format=json