Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence (Q39317407)

30 June 2019

title

Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence (English)

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30 June 2019

author name string

Y Tang

1

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30 June 2019

I Horikawa

2

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30 June 2019

M Ajiro

3

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30 June 2019

A I Robles

4

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30 June 2019

K Fujita

5

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A M Mondal

6

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30 June 2019

J K Stauffer

7

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Z-M Zheng

8

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C C Harris

9

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30 June 2019

language of work or name

English

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publication date

9 July 2012

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30 June 2019

published in

Oncogene

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30 June 2019

volume

32

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30 June 2019

issue

22

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30 June 2019

page(s)

2792-2798

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30 June 2019

https://scigraph.springernature.com/pub.10.1038/onc.2012.288

exact match

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cites work

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p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence

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Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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Multiple alternative splicing markers for ovarian cancer

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Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer

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Regulation of gene expression by the RNA-binding protein Sam68 in cancer.

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The oncoprotein SF2/ASF promotes non-small cell lung cancer survival by enhancing survivin expression.

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The gene encoding the splicing factor SF2/ASF is a proto-oncogene

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The splicing-factor oncoprotein SF2/ASF activates mTORC1.

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SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

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In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes.

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

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p53: guardian of cellular senescence

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p53 isoforms can regulate p53 transcriptional activity.

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Expression of novel p53 isoforms in oral lichen planus

21 January 2018

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The novel p53 isoform "delta p53" is a misfolded protein and does not bind the p21 promoter site

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Expression of C-terminal deleted p53 isoforms in neuroblastoma

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A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint

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p53 Isoforms: An Intracellular Microprocessor?

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Regulated expression and RNA processing of transcripts from the Srp20 splicing factor gene during the cell cycle

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Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing

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RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans

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SR proteins: a conserved family of pre-mRNA splicing factors

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Pre-mRNA splicing in the absence of an SR protein RS domain

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Alternative splicing of the multidrug resistance protein 1/ATP binding cassette transporter subfamily gene in ovarian cancer creates functional splice variants and is associated with increased expression of the splicing factors PTB and SRp20.

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

21 January 2018

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Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage

21 January 2018

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Applying the brakes to multisite SR protein phosphorylation: substrate-induced effects on the splicing kinase SRPK1

21 January 2018

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Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.288

Ceramide regulates SR protein phosphorylation during adenoviral infection.

21 January 2018

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Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo

21 January 2018

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Developmental regulation of SR protein phosphorylation and activity

21 January 2018

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ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.288

Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer

21 January 2018

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Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.288

Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.288

Transcriptional regulation of cellular senescence

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.288

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.288

Control of the papillomavirus early-to-late switch by differentially expressed SRp20

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.288

Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.288

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.288

Structural and functional analyses of Kaposi sarcoma-associated herpesvirus ORF57 nuclear localization signals in living cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.288

Alternative splicing of the Drosophila Dscam pre-mRNA is both temporally and spatially regulated

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22777358

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2012.288

1 reference

30 June 2019

Dimensions Publication ID

0 references

1 reference

30 June 2019

PubMed ID

22777358

1 reference

30 June 2019