Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis (Q39325296)

11 September 2017

Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis (English)

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5

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T Niault

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11 September 2017

F Kern

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E Doma

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2

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C Rupp

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3

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11 September 2017

language of work or name

English

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publication date

25 June 2012

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32

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2483-2492

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https://scigraph.springernature.com/pub.10.1038/onc.2012.254

11 September 2017

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cites work

Ras and Raf pathways in epidermis development and carcinogenesis

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia

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Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.254

The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.254

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.254

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

RalGDS is required for tumor formation in a model of skin carcinogenesis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Essential role of B-Raf in ERK activation during extraembryonic development

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Raf-1 regulates Rho signaling and cell migration

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Erk1/2 MAP kinases are required for epidermal G2/M progression

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.

21 January 2018

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p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis.

21 January 2018

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Raf-1 addiction in Ras-induced skin carcinogenesis

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Differential c-myc, c-jun, c-raf and p53 expression in squamous cell carcinoma of the head and neck: implication in drug and radioresistance.

21 January 2018

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Partner exchange: protein-protein interactions in the Raf pathway

21 January 2018

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Targets of Raf in tumorigenesis

21 January 2018

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

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Drug discovery: inhibitors that activate

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BRAF inhibitors: research accelerates in wake of positive findings.

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

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https://api.crossref.org/works/10.1038%2FONC.2012.254

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

21 January 2018

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Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.254

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Raf kinases in cancer-roles and therapeutic opportunities

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

Role of LIM kinases in normal and psoriatic human epidermis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.254

C-Raf is required for the initiation of lung cancer by K-Ras(G12D).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.254

c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.254

Resistance to BRAF inhibition in melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.254

Targeting RAF: trials and tribulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.254

Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.254

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.254

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.254

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.254

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Dimensions Publication ID

11 September 2017

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