p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737. (Q39457437)

12 September 2017

p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737. (English)

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12 September 2017

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Stephanie E. Combs

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12 September 2017

Katrin E Tagscherer

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12 September 2017

Anne Fassl

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12 September 2017

Tabea Sinkovic

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12 September 2017

Wilfried Roth

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12 September 2017

1 February 2012

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187-199

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https://scigraph.springernature.com/pub.10.1007/s10495-011-0664-3

12 September 2017

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cites work

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

BH3-only proteins Noxa, Bmf, and Bim are necessary for arsenic trioxide-induced cell death in myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Bcl-2-regulated apoptosis: mechanism and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

High-throughput detection and multiplex identification of cell contaminations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

JNK mediates UVB-induced apoptosis upstream lysosomal membrane permeabilization and Bcl-2 family proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Mcl-1 depletion in apoptosis elicited by ionizing radiation in peritoneal resident macrophages of C3H mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Gamma irradiation of human leukaemic cells HL-60 and MOLT-4 induces decrease in Mcl-1 and Bid, release of cytochrome c, and activation of caspase-8 and caspase-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Life in the balance: how BH3-only proteins induce apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Inhibition of cyclin-dependent kinases by purine analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Increase of BCNU sensitivity by wt-p53 gene therapy in glioblastoma lines depends on the administration schedule

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Enhanced radiosensitivity of malignant glioma cells after adenoviral p53 transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Susceptibility of myelomonocytic leukemia U937 cells to the induction of apoptosis by the non-peptidic Bcl-2 ligand HA14-1 is cell cycle phase-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Cell cycle G2/M arrest and activation of cyclin-dependent kinases associated with low-dose paclitaxel-induced sub-G1 apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive events

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Role of senescence and mitotic catastrophe in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

An accelerated senescence response to radiation in wild-type p53 glioblastoma multiforme cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Gene expression profiling and genetic markers in glioblastoma survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Mcl-1; the molecular regulation of protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Mcl-1 is a potential therapeutic target in multiple types of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

p53 suppresses cytokine induced, Stat5 mediated activation of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Reciprocal influence of the p53 and the hypoxic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Life, death, and ubiquitin: taming the mule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Noxa: at the tip of the balance between life and death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0664-3

10.1007/S10495-011-0664-3

21 January 2018

Identifiers

DOI

1 reference

12 September 2017

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