Sustained, high transgene expression in liver with plasmid vectors using optimized promoter-enhancer combinations (Q39514663)

12 September 2017

Sustained, high transgene expression in liver with plasmid vectors using optimized promoter-enhancer combinations (English)

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12 September 2017

4

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12 September 2017

Terese Magnusson

1

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12 September 2017

Rudolf Haase

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2

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12 September 2017

Martin Schleef

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3

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12 September 2017

Manfred Ogris

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5

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12 September 2017

language of work or name

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1 July 2011

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12 September 2017

Journal of Gene Medicine

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12 September 2017

13

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12 September 2017

7-8

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12 September 2017

382-391

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Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle

12 September 2017

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Nonviral gene transfer to skeletal, smooth, and cardiac muscle in living animals

21 January 2018

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Direct gene transfer into mouse muscle in vivo

21 January 2018

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Gene expression following direct injection of DNA into liver

21 January 2018

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CMV-beta-actin promoter directs higher expression from an adeno-associated viral vector in the liver than the cytomegalovirus or elongation factor 1 alpha promoter and results in therapeutic levels of human factor X in mice

21 January 2018

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Modulation of plasmid DNA methylation and expression in zebrafish embryos

21 January 2018

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Time course of gene expression after plasmid DNA gene transfer to the liver

21 January 2018

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Effects of inflammatory response on in vivo transgene expression by plasmid DNA in mice

21 January 2018

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Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression.

21 January 2018

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Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides

21 January 2018

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Reducing the immunostimulatory activity of CpG-containing plasmid DNA vectors for non-viral gene therapy

21 January 2018

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Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation

21 January 2018

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Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery

21 January 2018

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Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer

21 January 2018

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New recombination methods for Sinorhizobium meliloti genetics

21 January 2018

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Production of non viral DNA vectors

21 January 2018

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Toxicity and adaptive immune response to intracellular transgenes delivered by helper-dependent vs. first generation adenoviral vectors

21 January 2018

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EMBOSS: the European Molecular Biology Open Software Suite

21 January 2018

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Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN.

21 January 2018

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PROMO: detection of known transcription regulatory elements using species-tailored searches

21 January 2018

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Zinc-finger nucleases: the next generation emerges

21 January 2018

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The expanding universe of transposon technologies for gene and cell engineering.

21 January 2018

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Episomal vectors for gene therapy

21 January 2018

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pEPito: a significantly improved non-viral episomal expression vector for mammalian cells

21 January 2018

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A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells

21 January 2018

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Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA.

21 January 2018

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Hydroporation as the mechanism of hydrodynamic delivery

21 January 2018

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CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.

21 January 2018

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Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87.

21 January 2018

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Transgene expression is associated with copy number and cytomegalovirus promoter methylation in transgenic pigs

21 January 2018

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Gene therapy by intramuscular injection of plasmid DNA: studies on firefly luciferase gene expression in mice

21 January 2018

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Muscle damage after delivery of naked plasmid DNA into skeletal muscles is batch dependent.

21 January 2018

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Animal-free production of ccc-supercoiled plasmids for research and clinical applications

21 January 2018

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In vitro and in vivo comparative study of chimeric liver-specific promoters

21 January 2018

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Role of the cytomegalovirus major immediate early enhancer in acute infection and reactivation from latency

21 January 2018

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Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo

21 January 2018

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Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

21 January 2018

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Reactivation of silenced transgene expression in mouse liver by rapid, large-volume injection of isotonic solution.

21 January 2018

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Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

21 January 2018

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CpG content affects gene silencing in mice: evidence from novel transgenes

21 January 2018

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Strong muscle-specific regulatory cassettes based on multiple copies of the human slow troponin I gene upstream enhancer

21 January 2018

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High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoter

21 January 2018

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Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector.

21 January 2018

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Review--the use of immunosuppressive agents to prevent neutralizing antibodies against a transgene product

21 January 2018

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Challenges and strategies: the immune responses in gene therapy

21 January 2018

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Controlling the kinetics of transgene expression by plasmid design

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JGM.1585

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release_52pxjherfrdm7gui4n4445bmye

12 September 2017

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