Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. (Q39525276)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21670080%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition (English)

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4 February 2020

2

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4 February 2020

author name string

Jonathan L Coloff

1

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4 February 2020

Amanda G Nichols

3

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4 February 2020

Tingyu Liu

4

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4 February 2020

Catherine A Gallo

5

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4 February 2020

David R Plas

6

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4 February 2020

Jeffrey C Rathmell

7

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4 February 2020

language of work or name

English

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publication date

13 June 2011

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4 February 2020

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4 February 2020

volume

71

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4 February 2020

issue

15

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4 February 2020

page(s)

5204-5213

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Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells

4 February 2020

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13 September 2017

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Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation

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13 September 2017

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mTORC1 promotes survival through translational control of Mcl-1.

13 September 2017

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Unique biology of Mcl-1: therapeutic opportunities in cancer

13 September 2017

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

13 September 2017

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Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

13 September 2017

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Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

13 September 2017

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'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

13 September 2017

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

13 September 2017

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The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

13 September 2017

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

13 September 2017

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The Akt of translational control

13 September 2017

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

13 September 2017

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Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.

13 September 2017

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

13 September 2017

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

13 September 2017

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The LKB1 tumor suppressor negatively regulates mTOR signaling

13 September 2017

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Akt stimulates aerobic glycolysis in cancer cells

13 September 2017

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13 September 2017

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Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

13 September 2017

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13 September 2017

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13 September 2017

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13 September 2017

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13 September 2017

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13 September 2017

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13 September 2017

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Ubiquitin-independent degradation of antiapoptotic MCL-1.

13 September 2017

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Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

14 September 2017

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Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth

14 September 2017

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Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

14 September 2017

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Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.

14 September 2017

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Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

14 September 2017

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Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl

25 September 2017

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

17 June 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

17 June 2018

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Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation.

17 June 2018

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21 August 2018

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

21 August 2018

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Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

21 August 2018

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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 August 2018

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MCL-1, a member of the BLC-2 family, is induced rapidly in response to signals for cell differentiation or death, but not to signals for cell proliferation

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21670080

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-10-4531

1 reference

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4 February 2020

1 reference

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4 February 2020

PubMed publication ID

21670080

1 reference