A small interfering RNA targeting the KLF6 splice variant, KLF6-SV1, as gene therapy for gastric cancer (Q39549419)

13 September 2017

A small interfering RNA targeting the KLF6 splice variant, KLF6-SV1, as gene therapy for gastric cancer (English)

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13 September 2017

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Hui Chen

1

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13 September 2017

Lili Chen

2

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13 September 2017

Lingyu Sun

3

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13 September 2017

Hongqun Zhen

4

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13 September 2017

Xiaomei Li

5

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13 September 2017

Qifan Zhang

6

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13 September 2017

3 May 2011

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13 September 2017

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13 September 2017

14

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13 September 2017

4

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13 September 2017

339-352

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https://scigraph.springernature.com/pub.10.1007/s10120-011-0049-x

13 September 2017

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cites work

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21 January 2018

Focus on gastric cancer.

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Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

21 January 2018

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KLF6, a candidate tumor suppressor gene mutated in prostate cancer

21 January 2018

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Deletion, mutation, and loss of expression of KLF6 in human prostate cancer

21 January 2018

1 reference

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Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.

21 January 2018

1 reference

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Genetic alterations of the KLF6 gene in colorectal cancers.

21 January 2018

1 reference

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Krüppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells.

21 January 2018

1 reference

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A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response.

21 January 2018

1 reference

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Genetic alterations of the KLF6 gene in gastric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas

21 January 2018

1 reference

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Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma

21 January 2018

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Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma

21 January 2018

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Inactivation of the tumor suppressor Krüppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas

21 January 2018

1 reference

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Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma.

21 January 2018

1 reference

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Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation.

21 January 2018

1 reference

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Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer.

21 January 2018

1 reference

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Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination.

21 January 2018

1 reference

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KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma.

21 January 2018

1 reference

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Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.

21 January 2018

1 reference

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Functional role of the KLF6 tumour suppressor gene in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model.

21 January 2018

1 reference

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Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells

21 January 2018

1 reference

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Metastasis: a question of life or death

21 January 2018

1 reference

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Death and anti-death: tumour resistance to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

The role of KLF6 and its splice variants in cancer therapy

21 January 2018

1 reference

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BCL-2 family members and the mitochondria in apoptosis

21 January 2018

1 reference

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Mitochondrial control of apoptosis: an overview

21 January 2018

1 reference

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

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Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

Eradication of osteosarcoma lung metastases following intranasal interleukin-12 gene therapy using a nonviral polyethylenimine vector

21 January 2018

1 reference

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Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.

21 January 2018

1 reference

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Death receptors: signaling and modulation

21 January 2018

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p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

BH3 mimetics to improve cancer therapy; mechanisms and examples

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells

21 January 2018

1 reference

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Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

Inhibition of respiratory viruses by nasally administered siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

Interfering with disease: a progress report on siRNA-based therapeutics

21 January 2018

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Prospects of RNA interference therapy for cancer

21 January 2018

1 reference

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

21 January 2018

1 reference

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A Germline DNA Polymorphism Enhances Alternative Splicing of theKLF6Tumor Suppressor Gene and Is Associated with Increased Prostate Cancer Risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

A new role for the Krüppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10120-011-0049-X

[Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas]

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21538018

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21538018

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S10120-011-0049-X

1 reference

13 September 2017

1 reference