BH3 mimetics to improve cancer therapy; mechanisms and examples (Q24655483)

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

Europe PubMed Central

title

BH3 mimetics to improve cancer therapy; mechanisms and examples (English)

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Lin Zhang

1

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Lihua Ming

series ordinal

2

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Jian Yu

series ordinal

3

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language of work or name

English

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publication date

December 2007

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published in

Drug Resistance Updates

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volume

10

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issue

6

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page(s)

207-17

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cites work

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

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A stapled BID BH3 helix directly binds and activates BAX

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

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The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

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Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor

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Cell death: critical control points

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7 April 2017

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7 April 2017

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The expanding role of mitochondria in apoptosis

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

7 April 2017

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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2-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibition

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Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.

28 September 2017

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Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia

28 September 2017

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A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells

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28 September 2017

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28 September 2017

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Programmed anuclear cell death delimits platelet life span.

28 September 2017

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28 September 2017

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

28 November 2018

1 reference

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Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2

28 November 2018

1 reference

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The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.

28 November 2018

1 reference

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Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.

28 November 2018

1 reference

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(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance

28 November 2018

1 reference

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The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.

28 November 2018

1 reference

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Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells

28 November 2018

1 reference

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The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

28 November 2018

1 reference

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Identification of chelerythrine as an inhibitor of BclXL function

28 November 2018

1 reference

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Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

28 November 2018

1 reference

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Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

28 November 2018

1 reference

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Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.

28 November 2018

1 reference

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A preliminary clinical study of gossypol in advanced human cancer

28 November 2018

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12 December 2020

Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition

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12 December 2020

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

1 reference

12 December 2020

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

12 December 2020

Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

1 reference

12 December 2020

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

1 reference

12 December 2020

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma

1 reference

12 December 2020

(-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer

1 reference

12 December 2020

Peptides derived from BH3 domains of Bcl-2 family members: a comparative analysis of inhibition of Bcl-2, Bcl-x(L) and Bax oligomerization, induction of cytochrome c release, and activation of cell death

1 reference

12 December 2020

Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor

1 reference

12 December 2020

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide

1 reference

12 December 2020

Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells

1 reference

12 December 2020

RETRACTED: Inactivation of MAP kinase signalling in Myc transformed cells and rescue by LiCl inhibition of GSK3.

1 reference

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https://api.crossref.org/works/10.1016%2FJ.DRUP.2007.08.002

7 January 2021