Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells. (Q39678874)

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scientific article published on 8 June 2010

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English	Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.	scientific article published on 8 June 2010

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8 February 2020

Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells (English)

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8 February 2020

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Douglas R Spitz

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8 February 2020

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Mingjia Tan

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8 February 2020

Yueming Zhu

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8 February 2020

Jordan Kovacev

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8 February 2020

Yongchao Zhao

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8 February 2020

Zhen-Qiang Pan

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8 February 2020

Yi Sun

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8 February 2020

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8 June 2010

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8 February 2020

Free Radical Biology and Medicine

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8 February 2020

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8 February 2020

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8 February 2020

976-983

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8 February 2020

Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target

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14 September 2017

RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27

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14 September 2017

Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2.

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14 September 2017

NF-kappa B-mediated adaptive resistance to ionizing radiation

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14 September 2017

SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB.

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14 September 2017

SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection

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14 September 2017

Ubiquitin ligases: cell-cycle control and cancer

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14 September 2017

Effects of ionizing radiation in nonirradiated cells

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Function and regulation of cullin-RING ubiquitin ligases

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14 September 2017

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

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14 September 2017

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.

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Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses

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Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage

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Radiation-induced activation of nuclear factor-kappaB involves selective degradation of plasma membrane-associated I(kappa)B(alpha)

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14 September 2017

Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein

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Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

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14 September 2017

SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functions

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SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes

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14 September 2017

Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation

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14 September 2017

Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation

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Thiol-based antioxidants.

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14 September 2017

The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation

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Activators and target genes of Rel/NF-kappaB transcription factors

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The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

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14 September 2017

Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection

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14 September 2017

Expression, purification, and biochemical characterization of SAG, a ring finger redox-sensitive protein

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14 September 2017

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

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14 September 2017

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

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14 September 2017

SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

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Activation of p53 transcriptional activity by 1,10-phenanthroline, a metal chelator and redox sensitive compound

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

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Free radicals, antioxidant enzymes, and carcinogenesis

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Ionizing radiation induces expression and binding activity of the nuclear factor kappa B

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Regulation of heat shock-induced apoptosis by sensitive to apoptosis gene protein

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14 September 2017

SAG/ROC2/RBX2 E3 ligase promotes UVB-induced skin hyperplasia, but not skin tumors, by simultaneously targeting c-Jun/AP-1 and p27.

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14 September 2017

Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line

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14 September 2017

SAG protects human neuroblastoma SH-SY5Y cells against 1-methyl-4-phenylpyridinium ion (MPP+)-induced cytotoxicity via the downregulation of ROS generation and JNK signaling

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Elevated expression of SAG/ROC2/Rbx2/Hrt2 in human colon carcinomas: SAG does not induce neoplastic transformation, but antisense SAG transfection inhibits tumor cell growth

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Oxygen free radicals and metallothionein

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The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors

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Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts

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Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains

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17 June 2018

SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation

1 reference

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17 June 2018

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17 June 2018

Transduced Tat-SAG fusion protein protects against oxidative stress and brain ischemic insult

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21 August 2018

CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity.

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21 August 2018

Regulation of nitric oxide-induced apoptosis by sensitive to apoptosis gene protein.

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21 August 2018

SAG attenuates apoptotic cell death caused by simulated ischaemia/reoxygenation in rat cardiomyocytes.

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21 August 2018

Attenuation of ischemia-induced mouse brain injury by SAG, a redox-inducible antioxidant protein

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21 August 2018

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21 August 2018

Mean inactivation dose: a useful concept for intercomparison of human cell survival curves

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12 December 2020

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10.1016/J.FREERADBIOMED.2010.05.030

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8 February 2020

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8 February 2020

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