Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells (Q39819012)

14 September 2017

Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells (English)

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14 September 2017

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P Wei

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14 September 2017

M Shi

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S Barnum

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H Cho

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T Carlson

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J D Fraser

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30 July 2009

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52

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2142-2150

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10

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https://scigraph.springernature.com/pub.10.1007/s00125-009-1446-0

14 September 2017

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Glucotoxicity and beta-cell failure in type 2 diabetes mellitus

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The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy

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12 December 2020

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

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12 December 2020

Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

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12 December 2020

Metabolism of glucose in the islets of Langerhans

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12 December 2020

Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells

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12 December 2020

A dominant role for glucose in beta cell compensation of insulin resistance

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12 December 2020

Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells

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12 December 2020

Glucoreceptor mechanisms and the control of insulin release and biosynthesis

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12 December 2020

An underdiagnosed type of diabetes: the MODY syndromes. Pathophysiology, clinical presentation and renal disease progression

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12 December 2020

Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function

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12 December 2020

Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators

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12 December 2020

Allosteric activators of glucokinase: potential role in diabetes therapy

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12 December 2020

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

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12 December 2020

Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator

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12 December 2020

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase

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12 December 2020

Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway

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12 December 2020

Disruption of IRS-2 causes type 2 diabetes in mice

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12 December 2020

Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediat

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12 December 2020

Glucose-induced conformational changes in glucokinase mediate allosteric regulation: transient kinetic analysis

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12 December 2020

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

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12 December 2020

Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells

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12 December 2020

Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice

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12 December 2020

Targeting glucokinase activation for the treatment of type 2 diabetes--a status review.

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12 December 2020

Type 2 diabetes-a matter of beta-cell life and death?

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12 December 2020

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

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12 December 2020

Design of a potent, soluble glucokinase activator with excellent in vivo efficacy.

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12 December 2020

Cell biology: metabolism meets death

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12 December 2020

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

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12 December 2020

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

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12 December 2020

Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics

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12 December 2020

A novel glucokinase activator modulates pancreatic islet and hepatocyte function

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Small molecule glucokinase activators as novel anti-diabetic agents.

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12 December 2020

10.1007/S00125-009-1446-0

Identifiers

DOI

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14 September 2017

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