Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells (Q40592531)

21 September 2017

title

Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells (English)

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21 September 2017

Q Wang

1

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21 September 2017

L Li

2

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21 September 2017

E Xu

3

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21 September 2017

V Wong

4

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21 September 2017

C Rhodes

5

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21 September 2017

P L Brubaker

6

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21 September 2017

language of work or name

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5 February 2004

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21 September 2017

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21 September 2017

volume

47

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21 September 2017

issue

3

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21 September 2017

page(s)

478-487

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Biological actions and therapeutic potential of the glucagon-like peptides

21 September 2017

cites work

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Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetes

21 January 2018

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Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM.

21 January 2018

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Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).

21 January 2018

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The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake.

21 January 2018

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Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients.

21 January 2018

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Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect

21 January 2018

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Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study

21 January 2018

1 reference

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Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

21 January 2018

1 reference

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Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas

21 January 2018

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Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

21 January 2018

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Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice

21 January 2018

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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

21 January 2018

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Protein kinase B (PKB/Akt)--a key regulator of glucose transport?

21 January 2018

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PKB/AKT: functional insights from genetic models

21 January 2018

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Phosphatidylinositol 3-kinase signaling to Akt mediates survival in isolated canine islets of Langerhans

21 January 2018

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Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

21 January 2018

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Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

21 January 2018

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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

21 January 2018

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Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation

21 January 2018

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Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor

21 January 2018

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

21 January 2018

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Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells

21 January 2018

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Structure-Function of the Glucagon Receptor Family of G Protein-Coupled Receptors: The Glucagon, GIP, GLP-1, and GLP-2 Receptors

21 January 2018

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Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo

21 January 2018

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Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway.

21 January 2018

1 reference

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Glucagon-like peptide-2 receptor activation engages bad and glycogen synthase kinase-3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase.

21 January 2018

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Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells

21 January 2018

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Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

21 January 2018

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Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

21 January 2018

1 reference

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cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-004-1327-5

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-004-1327-5

Sustained expression of exendin-4 does not perturb glucose homeostasis, beta-cell mass, or food intake in metallothionein-preproexendin transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-004-1327-5

Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice

21 January 2018

1 reference

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Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy

21 January 2018

1 reference

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Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-004-1327-5

Endoproteolysis by isolated membrane peptidases reveal metabolic stability of glucagon-like peptide-1 analogs, exendins-3 and -4

21 January 2018

1 reference

12 December 2020

Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7-36 amide] after subcutaneous injection in healthy volunteers. Dose-response-relationships.

1 reference

12 December 2020

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

1 reference

12 December 2020

Differential effects of subcutaneous GLP-1 on gastric emptying, antroduodenal motility, and pancreatic function in men

1 reference

12 December 2020

Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs

1 reference

12 December 2020

Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors

1 reference

12 December 2020

Comet assay and DNA flow cytometry analysis of staurosporine-induced apoptosis

1 reference

12 December 2020

Integrative mitogenic role of protein kinase B/Akt in beta-cells.

1 reference

12 December 2020

Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I

1 reference

12 December 2020

Glucagonostatic and insulinotropic action of glucagonlike peptide I-(7-36)-amide

1 reference

12 December 2020

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

1 reference

12 December 2020

Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling

1 reference

12 December 2020

Initiation of increased pancreatic islet growth in young normoglycemic mice (Umeå +/?)

1 reference

12 December 2020

Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.

1 reference

12 December 2020

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

1 reference

12 December 2020

10.1007/S00125-004-1327-5

Identifiers

DOI

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21 September 2017

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