Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages (Q40077211)

17 September 2017

Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages (English)

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17 September 2017

Zhao Ren

1

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17 September 2017

Dale Schenk

series ordinal

2

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17 September 2017

Guriqbal S Basi

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3

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17 September 2017

I Paul Shapiro

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4

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17 September 2017

language of work or name

English

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publication date

21 September 2007

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Journal of Biological Chemistry

17 September 2017

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17 September 2017

282

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17 September 2017

48

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17 September 2017

35350-35360

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

17 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Implication of APP secretases in notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Notch signaling: from the outside in

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Generation of amyloid beta protein from its precursor is sequence specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Secretion of long Abeta-related peptides processed at epsilon-cleavage site is dependent on the alpha-secretase pre-cutting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

kuzbanian-mediated cleavage of Drosophila Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Membrane inserted APP fragments containing the beta A4 sequence of Alzheimer's disease do not aggregate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Secretion of the Notch-1 Abeta-like peptide during Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Mutations in APP have independent effects on Abeta and CTFgamma generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Activated Notch1 associates with a presenilin‐1/γ‐secretase docking site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702739200

21 January 2018

Identifiers

DOI

10.1074/JBC.M702739200

1 reference

17 September 2017

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