Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity (Q40112272)

17 September 2017

Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity (English)

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17 September 2017

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Jun Li

1

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17 September 2017

Christine Tumanut

2

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17 September 2017

Julie-Ann Gavigan

3

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17 September 2017

Waan-Jeng Huang

4

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17 September 2017

Eric N Hampton

5

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17 September 2017

Rachelle Tumanut

6

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17 September 2017

Ka Fai Suen

7

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17 September 2017

John W Trauger

8

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17 September 2017

Glen Spraggon

9

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17 September 2017

Scott A Lesley

10

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17 September 2017

Gene Liau

11

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17 September 2017

David Yowe

12

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17 September 2017

Jennifer L Harris

13

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17 September 2017

language of work or name

English

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publication date

1 September 2007

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17 September 2017

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17 September 2017

406

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17 September 2017

2

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17 September 2017

203-207

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Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

17 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

The proprotein convertases are potential targets in the treatment of dyslipidemia

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Effect of mutations in the PCSK9 gene on the cell surface LDL receptors

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

The role of pro regions in protein folding.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Pro-sequence of subtilisin can guide the refolding of denatured subtilisin in an intermolecular process.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

The alpha-lytic protease pro-region does not require a physical linkage to activate the protease domain in vivo

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

Genetic variants in PCSK9 affect the cholesterol level in Japanese

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

LDL-receptor structure. Calcium cages, acid baths and recycling receptors.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1948958

20 August 2018

Identifiers

DOI

10.1042/BJ20070186

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17 September 2017

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17 September 2017

PubMed publication ID

17608623

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