The proprotein convertases are potential targets in the treatment of dyslipidemia (Q36757387)

16 August 2017

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title

The proprotein convertases are potential targets in the treatment of dyslipidemia (English)

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16 August 2017

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Annik Prat

2

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Nabil Seidah

object named as

Nabil G Seidah

series ordinal

1

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language of work or name

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10 March 2007

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Journal of Molecular Medicine

16 August 2017

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16 August 2017

85

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16 August 2017

7

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16 August 2017

685-696

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https://scigraph.springernature.com/pub.10.1007/s00109-007-0172-7

16 August 2017

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cites work

Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0172-7

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0172-7

Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0172-7

Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0172-7

Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0172-7

Precursor convertases in the secretory pathway, cytosol and extracellular milieu

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0172-7

Selective expression of the proprotein convertases furin, pc5, and pc7 in proliferating vascular smooth muscle cells of the rat aorta in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0172-7

Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-007-0172-7

Protease variants, LDL, and coronary heart disease

21 January 2018

1 reference

12 December 2020

Limited redundancy of the proprotein convertase furin in mouse liver

1 reference

12 December 2020

Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1.

1 reference

12 December 2020

Effect of mutations in the PCSK9 gene on the cell surface LDL receptors

1 reference

12 December 2020

Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment

1 reference

12 December 2020

Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase

1 reference

12 December 2020

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases

1 reference

12 December 2020

The role of the LDL receptor in apolipoprotein B secretion

1 reference

12 December 2020

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

1 reference

12 December 2020

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

1 reference

12 December 2020

Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

1 reference

12 December 2020

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions

1 reference

12 December 2020

Identification of QTLs for serum lipid levels in a female sib-pair cohort: a novel application to improve the power of two-locus linkage analysis

1 reference

12 December 2020

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

1 reference

12 December 2020

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

1 reference

12 December 2020

Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis

1 reference

12 December 2020

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

1 reference

12 December 2020

Cholesterol absorption blockade with ezetimibe

1 reference

12 December 2020

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

1 reference

12 December 2020

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

1 reference

12 December 2020

Proteolytic processing of human prorenin in renal and non-renal tissues

1 reference

12 December 2020

Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase

1 reference

12 December 2020

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

1 reference

12 December 2020

Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor

1 reference

12 December 2020

Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

1 reference

12 December 2020

Statin therapy for prevention and treatment of acute and chronic cardiovascular disease: update on recent trials and metaanalyses

1 reference

12 December 2020

Proprotein convertases: lessons from knockouts

1 reference

12 December 2020

Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7

1 reference

12 December 2020

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

1 reference

12 December 2020

Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo

1 reference

12 December 2020

The proprotein convertases and their implication in sterol and/or lipid metabolism

1 reference

12 December 2020

A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

1 reference

12 December 2020

Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia

1 reference

12 December 2020

Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions

1 reference

12 December 2020

Characterization of human c-fes/fps reveals a new transcription unit (fur) in the immediately upstream region of the proto-oncogene

1 reference

12 December 2020

Curbing activation: proprotein convertases in homeostasis and pathology

1 reference

12 December 2020

Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor.

1 reference

12 December 2020

Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity

1 reference

12 December 2020

Angptl3 regulates lipid metabolism in mice

1 reference

12 December 2020

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

1 reference

12 December 2020

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

1 reference

12 December 2020

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

1 reference

12 December 2020

Biomedicine. Lowering LDL--not only how low, but how long?

1 reference

12 December 2020

Genetic variants in PCSK9 affect the cholesterol level in Japanese

1 reference

12 December 2020

Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy

1 reference

12 December 2020

Dual regulation of the LDL receptor--some clarity and new questions

1 reference

12 December 2020

Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism.

1 reference

12 December 2020

A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

1 reference

12 December 2020

Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9.

1 reference

12 December 2020

Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins.

1 reference

12 December 2020

Furin at the cutting edge: from protein traffic to embryogenesis and disease

1 reference

12 December 2020

The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors

1 reference

12 December 2020

RNA and protein localisations of TGF beta 2 in the early mouse embryo suggest an involvement in cardiac development

1 reference

12 December 2020

Are lower levels of low-density lipoprotein cholesterol beneficial? a review of recent data

1 reference

12 December 2020

Emilin1 links TGF-beta maturation to blood pressure homeostasis

1 reference

12 December 2020

A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol

1 reference

12 December 2020

Proprotein convertases: "master switches" in the regulation of tumor growth and progression

1 reference

12 December 2020

A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus

1 reference

12 December 2020

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

1 reference

12 December 2020

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

12 December 2020

The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity.

1 reference

12 December 2020

New insights into the regulation of HDL metabolism and reverse cholesterol transport

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12 December 2020

Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases

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12 December 2020

Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase/p70(s6)-kinase activation in vascular smooth muscle cells

1 reference

12 December 2020

Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo.

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12 December 2020

Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis.

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12 December 2020

Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling

1 reference

12 December 2020

The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments

1 reference

12 December 2020

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

1 reference

12 December 2020

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

1 reference

12 December 2020

Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia

1 reference

12 December 2020

A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation.

1 reference

12 December 2020

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse

1 reference

12 December 2020

Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein

1 reference

12 December 2020

The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P.

1 reference

12 December 2020

Site-1 protease is required for cartilage development in zebrafish

1 reference

12 December 2020

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

1 reference

12 December 2020

Introduction to the plasma lipoproteins

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12 December 2020

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

1 reference

12 December 2020

Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia

1 reference

12 December 2020

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

1 reference

12 December 2020

Functional analysis of secreted and transmembrane proteins critical to mouse development.

1 reference

12 December 2020

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface

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12 December 2020

Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.

1 reference

12 December 2020

Human and mouse proteases: a comparative genomic approach

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12 December 2020

Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation

1 reference

12 December 2020

The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population

1 reference

12 December 2020

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

1 reference

12 December 2020

Atherogenic lipoprotein particles in atherosclerosis

1 reference

12 December 2020

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

1 reference

12 December 2020

Additive effect of mutations in LDLR and PCSK9 genes on the phenotype of familial hypercholesterolemia

1 reference

12 December 2020

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c

1 reference

12 December 2020

Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response

1 reference

12 December 2020

Bioinformatics of proteases in the MEROPS database.

1 reference

12 December 2020

TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity.

1 reference

12 December 2020

Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage

1 reference

12 December 2020

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

1 reference

12 December 2020

Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels

1 reference

12 December 2020

TGF-β Regulation by Emilin1: New Links in the Etiology of Hypertension

1 reference

12 December 2020

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

1 reference

12 December 2020

Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins

1 reference

12 December 2020

alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

1 reference

12 December 2020

Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4

1 reference

12 December 2020

Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage

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12 December 2020

The mystery of PCSK9.

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12 December 2020

Towards third generation matrix metalloproteinase inhibitors for cancer therapy

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12 December 2020

Structure-function analysis of the prosegment of the proprotein convertase PC5A.

1 reference

12 December 2020

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

1 reference

12 December 2020

The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation

1 reference

12 December 2020

10.1007/S00109-007-0172-7

Identifiers

DOI

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16 August 2017

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PubMed ID

17351764